Madden, David JParks, Emily LTallman, Catherine WBoylan, Maria AHoagey, David ACocjin, Sally BPackard, Lauren EJohnson, Micah AChou, Ying-HuiPotter, Guy GChen, Nan-KueiSiciliano, Rachel EMonge, Zachary AHonig, Jesse ADiaz, Michele T2018-01-032018-01-032017-06https://hdl.handle.net/10161/15954Age-related decline in fluid cognition can be characterized as a disconnection among specific brain structures, leading to a decline in functional efficiency. The potential sources of disconnection, however, are unclear. We investigated imaging measures of cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume as mediators of the relation between age and fluid cognition, in 145 healthy, community-dwelling adults 19-79 years of age. At a general level of analysis, with a single composite measure of fluid cognition and single measures of each of the 3 imaging modalities, age exhibited an independent influence on the cognitive and imaging measures, and the imaging variables did not mediate the age-cognition relation. At a more specific level of analysis, resting-state functional connectivity of sensorimotor networks was a significant mediator of the age-related decline in executive function. These findings suggest that different levels of analysis lead to different models of neurocognitive disconnection, and that resting-state functional connectivity, in particular, may contribute to age-related decline in executive function.CognitionCortexDiffusion tensor imagingMagnetic resonance imagingMediationAdultAgedCognitionCognitive AgingDiffusion Tensor ImagingExecutive FunctionFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedRestSensorimotor CortexWhite MatterJournal article1558-1497