Jou, JaniceDiehl, Anna Mae2011-06-212010-04https://hdl.handle.net/10161/4329Epithelial-mesenchymal transitions (EMTs) are believed to play a role in invasion and metastasis of many types of tumors. In this issue of the JCI, Chen et al. show that a gene that has been associated with aggressive biology in hepatocellular carcinomas initiates a molecular cascade that results in EMT.en-USAnimalsCarcinoma, HepatocellularCell DifferentiationDNA HelicasesDNA-Binding ProteinsEpithelial CellsHumansLiver CirrhosisLiver NeoplasmsMesodermMicecdc42 GTP-Binding Protein