Browsing by Author "Algehainy, Naseh"
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Item Open Access RNase L Is Involved in Liposaccharide-Induced Lung Inflammation(Viruses) Wei, Ruhan; Chen, Guanmin; Algehainy, Naseh; Zeng, Chun; Liu, Chunfang; Liu, Hongli; Liu, Wendy; Stacey, Dennis; Zhou, AiminRNase L mediates interferon (IFN) function during viral infection and cell proliferation. Furthermore, the role of RNase L in the regulation of gene expression, cell apoptosis, autophagy, and innate immunity has been well established in the last decade. Tissue distribution reveals that RNase L is highly expressed in the lung and other organs. However, the physiological roles of RNase L in the lung are largely unknown. In this study, we found that polysaccharide (LPS)-induced acute lung injury (ALI) was remarkably intensified in mice deficient in RNase L compared to wild type mice under the same condition. Furthermore, we found that RNase L mediated the TLR4 signaling pathway, and regulated the expression of various pro- and anti-inflammatory genes in the lung tissue and blood. Most importantly, RNase L function in macrophages during LPS stimulation may be independent of the 2-5A system. These findings demonstrate a novel role of RNase L in the immune response via an atypical molecular mechanism.