Browsing by Author "Baillie, J Kenneth"

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    Sepsis Subclasses: A Framework for Development and Interpretation.
    (Critical care medicine, 2021-05) DeMerle, Kimberley M; Angus, Derek C; Baillie, J Kenneth; Brant, Emily; Calfee, Carolyn S; Carcillo, Joseph; Chang, Chung-Chou H; Dickson, Robert; Evans, Idris; Gordon, Anthony C; Kennedy, Jason; Knight, Julian C; Lindsell, Christopher J; Liu, Vincent; Marshall, John C; Randolph, Adrienne G; Scicluna, Brendon P; Shankar-Hari, Manu; Shapiro, Nathan I; Sweeney, Timothy E; Talisa, Victor B; Tang, Benjamin; Thompson, B Taylor; Tsalik, Ephraim L; van der Poll, Tom; van Vught, Lonneke A; Wong, Hector R; Yende, Sachin; Zhao, Huiying; Seymour, Christopher W
    Sepsis is defined as a dysregulated host response to infection that leads to life-threatening acute organ dysfunction. It afflicts approximately 50 million people worldwide annually and is often deadly, even when evidence-based guidelines are applied promptly. Many randomized trials tested therapies for sepsis over the past 2 decades, but most have not proven beneficial. This may be because sepsis is a heterogeneous syndrome, characterized by a vast set of clinical and biologic features. Combinations of these features, however, may identify previously unrecognized groups, or "subclasses" with different risks of outcome and response to a given treatment. As efforts to identify sepsis subclasses become more common, many unanswered questions and challenges arise. These include: 1) the semantic underpinning of sepsis subclasses, 2) the conceptual goal of subclasses, 3) considerations about study design, data sources, and statistical methods, 4) the role of emerging data types, and 5) how to determine whether subclasses represent "truth." We discuss these challenges and present a framework for the broader study of sepsis subclasses. This framework is intended to aid in the understanding and interpretation of sepsis subclasses, provide a mechanism for explaining subclasses generated by different methodologic approaches, and guide clinicians in how to consider subclasses in bedside care.
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    The 2018 Lake Louise Acute Mountain Sickness Score.
    (High Altitude Medicine and Biology, 2018-03-13) Roach, Robert C; Hackett, Peter H; Oelz, Oswald; Bärtsch, Peter; Luks, Andrew M; MacInnis, Martin J; Baillie, J Kenneth; Lake Louise AMS Score Consensus Committee
    Roach, Robert C., Peter H. Hackett, Oswald Oelz, Peter Bärtsch, Andrew M. Luks, Martin J. MacInnis, J. Kenneth Baillie, and The Lake Louise AMS Score Consensus Committee. The 2018 Lake Louise Acute Mountain Sickness Score. High Alt Med Biol 19:1-4, 2018.- The Lake Louise Acute Mountain Sickness (AMS) scoring system has been a useful research tool since first published in 1991. Recent studies have shown that disturbed sleep at altitude, one of the five symptoms scored for AMS, is more likely due to altitude hypoxia per se, and is not closely related to AMS. To address this issue, and also to evaluate the Lake Louise AMS score in light of decades of experience, experts in high altitude research undertook to revise the score. We here present an international consensus statement resulting from online discussions and meetings at the International Society of Mountain Medicine World Congress in Bolzano, Italy, in May 2014 and at the International Hypoxia Symposium in Lake Louise, Canada, in February 2015. The consensus group has revised the score to eliminate disturbed sleep as a questionnaire item, and has updated instructions for use of the score.