Browsing by Author "Barreto, Amanda D"
Now showing 1 - 2 of 2
- Results Per Page
- Sort Options
Item Open Access Advancing drug discovery for glomerulopathies using stem-cell-derived kidney models.(Trends in pharmacological sciences, 2023-04) Barreto, Amanda D; Burt, Morgan A; Musah, SamiraChronic kidney disease (CKD) is an epidemic that affects millions worldwide. The glomerulus, a specialized unit of the nephron, is highly susceptible to injury. Human induced pluripotent stem cells (iPSCs) have emerged as an attractive resource for modeling kidney disease and therapeutic discovery.Item Open Access Translating Organoids into Artificial Kidneys.(Current transplantation reports, 2022-01) Kalejaiye, Titilola D; Barreto, Amanda D; Musah, SamiraPurpose of review
Kidney disease affects more than 13% of the world population, and current treatment options are limited to dialysis and organ transplantation. The generation of kidney organoids from human-induced pluripotent stem (hiPS) cells could be harnessed to engineer artificial organs and help overcome the challenges associated with the limited supply of transplantable kidneys. The purpose of this article is to review the progress in kidney organoid generation and transplantation and highlight some existing challenges in the field. We also examined possible improvements that could help realize the potential of organoids as artificial organs or alternatives for kidney transplantation therapy.Recent findings
Organoids are useful for understanding the mechanisms of kidney development, and they provide robust platforms for drug screening, disease modeling, and generation of tissues for organ replacement therapies. Efforts to design organoids rely on the ability of cells to self-assemble and pattern themselves into recognizable tissues. While existing protocols for generating organoids result in multicellular structures reminiscent of the developing kidney, many do not yet fully recapitulate the complex cellular composition, structure, and functions of the intact kidney. Recent advances toward achieving these goals include identifying cell culture conditions that produce organoids with improved vasculature and cell maturation and functional states. Still, additional improvements are needed to enhance tissue patterning, specialization, and function, and avoid tumorigenicity after transplantation.Summary
This report focuses on kidney organoid studies, advancements and limitations, and future directions for improvements towards transplantation.