Browsing by Author "Beckford, Floyd A"
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Item Open Access Binuclear manganese-iron complexes containing ferrocenyl thiosemicarbazones: Biological activity and carbon monoxide-releasing properties(Inorganica Chimica Acta, 2020-07) Lawrence, Madelyn L; Shell, Steven M; Beckford, Floyd AItem Open Access Chemistry and biology of manganese carbon-releasing molecules containing thiosemicarbazone ligands(Journal of Photochemistry and Photobiology A: Chemistry, 2019-04) Daniels, Hannah G; Fast, Olivia G; Shell, Steven M; Beckford, Floyd AItem Open Access Copper complexes containing thiosemicarbazones derived from 6-nitropiperonal: Antimicrobial and biophysical properties(Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2017-08) Beckford, Floyd A; Webb, Kelsey RItem Open Access Novel microwave synthesis of half-sandwich [(η6 -C6 H6 )Ru] complexes and an evaluation of the biological activity and biochemical reactivity(Applied Organometallic Chemistry, 2013-07) Beckford, Floyd A; Stott, Alyssa; Gonzalez‐Sarrías, Antonio; Seeram, Navindra PItem Open Access Polynuclear ruthenium organometallic complexes containing a 1,3,5-triazine ligand: synthesis, DNA interaction, and biological activity(JBIC Journal of Biological Inorganic Chemistry, 2018-12) Beckford, Floyd A; Niece, Madison B; Lassiter, Brittany P; Beebe, Stephen J; Holder, Alvin AItem Open Access Polynuclear ruthenium organometallic compounds induce DNA damage in human cells identified by the nucleotide excision repair factor XPC(Bioscience Reports, 2019-07-31) Fast, Olivia G; Gentry, Brittany; Strouth, Liah; Niece, Madison B; Beckford, Floyd A; Shell, Steven MAbstract Ruthenium organometallic compounds represent an attractive avenue in developing alternatives to platinum-based chemotherapeutic agents. While evidence has been presented indicating ruthenium-based compounds interact with isolated DNA in vitro, it is unclear what effect these compounds exert in cells. Moreover, the antibiotic efficacy of polynuclear ruthenium organometallic compounds remains uncertain. In the present study, we report that exposure to polynuclear ruthenium organometallic compounds induces recruitment of damaged DNA sensing protein Xeroderma pigmentosum Group C into chromatin-immobilized foci. Additionally, we observed one of the tested polynuclear ruthenium organometallic compounds displayed increased cytotoxicity against human cells deficient in nucleotide excision repair (NER). Taken together, these results suggest that polynuclear ruthenium organometallic compounds induce DNA damage in cells, and that cellular resistance to these compounds may be influenced by the NER DNA repair phenotype of the cells.Item Open Access Synthesis, Characterisation, and Preliminary In Vitro Studies of Vanadium(IV) Complexes with a Schiff Base and Thiosemicarbazones as Mixed Ligands(European Journal of Inorganic Chemistry, 2012-02) Lewis, Nerissa A; Liu, Fange; Seymour, Luke; Magnusen, Anthony; Erves, Travis R; Arca, Jessa Faye; Beckford, Floyd A; Venkatraman, Ramaiyer; González‐Sarrías, Antonio; Fronczek, Frank R; VanDerveer, Don G; Seeram, Navindra P; Liu, Aimin; Jarrett, William L; Holder, Alvin AItem Open Access Synthesis, characterization, DNA binding, topoisomerase inhibition, and apoptosis induction studies of a novel cobalt(III) complex with a thiosemicarbazone ligand(Journal of Inorganic Biochemistry, 2020-02) Beebe, Stephen J; Celestine, Michael J; Bullock, Jimmie L; Sandhaus, Shayna; Arca, Jessa Faye; Cropek, Donald M; Ludvig, Tekettay A; Foster, Sydney R; Clark, Jasmine S; Beckford, Floyd A; Tano, Criszcele M; Tonsel-White, Elizabeth A; Gurung, Raj K; Stankavich, Courtney E; Tse-Dinh, Yuk-Ching; Jarrett, William L; Holder, Alvin A