Browsing by Author "Berger, David"
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Item Open Access Essays in Empirical Macroeconomics(2022) Chun, SuminThis dissertation is comprised of two chapters in empirical macroeconomics. In Chapter 1, I study whether employer mergers cause harm to employee outcomes. Employer mergers within the same labor market increases market concentration, which has been argued to be associated with negative effect on worker wages. I find that in a sample of European mergers drawn from 21 countries, only mergers in the most concentrated markets decrease worker wages. Along with wage, however, employer productivity also declines. I further find that the extent of the negative effect depends on the strength of worker unions and collective wage setting. As expected, stronger unions mitigate the adverse effect of increased concentration on employee wages. Overall, the results suggest that employer consolidation does decrease wages especially where workers have the least collective power. However, whether this is a result of the abuse of employer's market power is uncertain, given the contemporaneous loss in employer productivity.
In Chapter 2, I analyze the effect of IMF's Covid support to developing and emerging economies. Using three distinct proxies of economic activity in the first two years of the pandemic, I find that the pandemic-related funding from the IMF supported economic recovery from the initial downturn. I also find that fiscal relief that supported immediate government spending for Covid response was probably an important mechanism. Overall, the preliminary evidence suggests that IMF financing helped lessen the negative effects of the pandemic on economic activity.
Item Open Access Heterogeneity in Mortgage Refinancing(2022-06-22) Wu, JuliaMany households who would benefit from and are eligible to refinance their mortgages fail to do so. A recent literature has demonstrated a significant degree of heterogeneity in the propensity to refinance across various dimensions, yet much heterogeneity is left unexplained. In this paper, I use a clustering regression to characterize heterogeneity in mortgage refinancing by estimating the distribution of propensities to refinance. A key novelty to my approach is that I do so without relying on borrower characteristics, allowing me to recover the full degree of heterogeneity, rather than simply the extent to which the propensity to refinance varies with a given observable. I then explore the role of both observed and unobserved heterogeneity in group placement by regressing group estimates on a set of demographic characteristics. As a complement to my analysis, I provide evidence from a novel dataset of detailed information on borrower perspectives on mortgage refinancing to paint a more nuanced picture of how household characteristics and behavioral mechanisms play into the decision to refinance. I find a significant degree of heterogeneity in both the average and marginal propensity to refinance across households. While observables such as education, race and income do significantly correlate with group heterogeneity, it is clear that much heterogeneity may still be attributed to the presence of unobservable characteristics.Item Restricted Immunization with cocktail of HIV-derived peptides in montanide ISA-51 is immunogenic, but causes sterile abscesses and unacceptable reactogenicity.(PLoS One, 2010-08-10) Graham, Barney S; McElrath, M Juliana; Keefer, Michael C; Rybczyk, Kyle; Berger, David; Weinhold, Kent J; Ottinger, Janet; Ferarri, Guido; Montefiori, David C; Stablein, Don; Smith, Carol; Ginsberg, Richard; Eldridge, John; Duerr, Ann; Fast, Pat; Haynes, Barton F; AIDS Vaccine Evaluation GroupBACKGROUND: A peptide vaccine was produced containing B and T cell epitopes from the V3 and C4 Envelope domains of 4 subtype B HIV-1 isolates (MN, RF, CanO, & Ev91). The peptide mixture was formulated as an emulsion in incomplete Freund's adjuvant (IFA). METHODS: Low-risk, healthy adult subjects were enrolled in a randomized, placebo-controlled dose-escalation study, and selected using criteria specifying that 50% in each study group would be HLA-B7+. Immunizations were scheduled at 0, 1, and 6 months using a total peptide dose of 1 or 4 mg. Adaptive immune responses in16 vaccine recipients and two placebo recipients after the 2nd immunization were evaluated using neutralization assays of sera, as well as ELISpot and ICS assays of cryopreserved PBMCs to assess CD4 and CD8 T-cell responses. In addition, (51)Cr release assays were performed on fresh PBMCs following 14-day stimulation with individual vaccine peptide antigens. RESULTS: 24 subjects were enrolled; 18 completed 2 injections. The study was prematurely terminated because 4 vaccinees developed prolonged pain and sterile abscess formation at the injection site-2 after dose 1, and 2 after dose 2. Two other subjects experienced severe systemic reactions consisting of headache, chills, nausea, and myalgia. Both reactions occurred after the second 4 mg dose. The immunogenicity assessments showed that 6/8 vaccinees at each dose level had detectable MN-specific neutralizing (NT) activity, and 2/7 HLA-B7+ vaccinees had classical CD8 CTL activity detected. However, using both ELISpot and ICS, 8/16 vaccinees (5/7 HLA-B7+) and 0/2 controls had detectable vaccine-specific CD8 T-cell responses. Subjects with moderate or severe systemic or local reactions tended to have more frequent T cell responses and higher antibody responses than those with mild or no reactions. CONCLUSIONS: The severity of local responses related to the formulation of these four peptides in IFA is clinically unacceptable for continued development. Both HIV-specific antibody and T cell responses were induced and the magnitude of response correlated with the severity of local and systemic reactions. If potent adjuvants are necessary for subunit vaccines to induce broad and durable immune responses, careful, incremental clinical evaluation is warranted to minimize the risk of adverse events. TRIAL REGISTRATION: ClinicalTrials.gov NCT00000886.