Browsing by Author "Cable, Jennifer"
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Item Open Access Lessons from the pandemic: Responding to emerging zoonotic viral diseases-a Keystone Symposia report.(Annals of the New York Academy of Sciences, 2022-10) Cable, Jennifer; Fauci, Anthony; Dowling, William E; Günther, Stephan; Bente, Dennis A; Yadav, Pragya Dhruv; Madoff, Lawrence C; Wang, Lin-Fa; Arora, Rahul K; Van Kerkhove, Maria; Chu, May C; Jaenisch, Thomas; Epstein, Jonathan H; Frost, Simon David William; Bausch, Daniel G; Hensley, Lisa E; Bergeron, Éric; Sitaras, Ioannis; Gunn, Michael D; Geisbert, Thomas W; Muñoz-Fontela, César; Krammer, Florian; de Wit, Emmie; Nordenfelt, Pontus; Saphire, Erica Ollmann; Gilbert, Sarah C; Corbett, Kizzmekia S; Branco, Luis M; Baize, Sylvain; van Doremalen, Neeltje; Krieger, Marco A; Clemens, Sue Ann Costa; Hesselink, Renske; Hartman, DanThe COVID-19 pandemic caught the world largely unprepared, including scientific and policy communities. On April 10-13, 2022, researchers across academia, industry, government, and nonprofit organizations met at the Keystone symposium "Lessons from the Pandemic: Responding to Emerging Zoonotic Viral Diseases" to discuss the successes and challenges of the COVID-19 pandemic and what lessons can be applied moving forward. Speakers focused on experiences not only from the COVID-19 pandemic but also from outbreaks of other pathogens, including the Ebola virus, Lassa virus, and Nipah virus. A general consensus was that investments made during the COVID-19 pandemic in infrastructure, collaborations, laboratory and manufacturing capacity, diagnostics, clinical trial networks, and regulatory enhancements-notably, in low-to-middle income countries-must be maintained and strengthened to enable quick, concerted responses to future threats, especially to zoonotic pathogens.Item Open Access Organoids as tools for fundamental discovery and translation-a Keystone Symposia report.(Annals of the New York Academy of Sciences, 2022-12) Cable, Jennifer; Lutolf, Matthias P; Fu, Jianping; Park, Sunghee Estelle; Apostolou, Athanasia; Chen, Shuibing; Song, Cheng Jack; Spence, Jason R; Liberali, Prisca; Lancaster, Madeline; Meier, Anna B; Pek, Nicole Min Qian; Wells, James M; Capeling, Meghan M; Uzquiano, Ana; Musah, Samira; Huch, Meritxell; Gouti, Mina; Hombrink, Pleun; Quadrato, Giorgia; Urenda, Jean-PaulComplex three-dimensional in vitro organ-like models, or organoids, offer a unique biological tool with distinct advantages over two-dimensional cell culture systems, which can be too simplistic, and animal models, which can be too complex and may fail to recapitulate human physiology and pathology. Significant progress has been made in driving stem cells to differentiate into different organoid types, though several challenges remain. For example, many organoid models suffer from high heterogeneity, and it can be difficult to fully incorporate the complexity of in vivo tissue and organ development to faithfully reproduce human biology. Successfully addressing such limitations would increase the viability of organoids as models for drug development and preclinical testing. On April 3-6, 2022, experts in organoid development and biology convened at the Keystone Symposium "Organoids as Tools for Fundamental Discovery and Translation" to discuss recent advances and insights from this relatively new model system into human development and disease.