Browsing by Author "Cantrell, Sarah"

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    ItemOpen Access
    Effectiveness of Synchronous Postdischarge Contacts on Health Care Use and Patient Satisfaction : A Systematic Review and Meta-analysis.
    (Ann Intern Med, 2025-01-14) Boggan, Joel C; Sankineni, Spoorthi; Dennis, Paul A; Chen, Dazhe; Sledge, Tina Wong; Halpern, David; Rushton, Sharron; Williams, John W; Der, Tatyana; Tabriz, Amir Alishahi; Gordon, Adelaide M; Jacobs, Morgan; Boucher, Nathan A; Colandrea, Maria; Alexopoulos, Anastasia-Stefania; Roman Jones, Joanne; Leflore-Lloyd, Nina; Cantrell, Sarah; Goldstein, Karen M; Gierisch, Jennifer M
    BACKGROUND: Postdischarge contacts (PDCs) after hospitalization are common practice, but their effectiveness in reducing use of acute care after discharge remains unclear. PURPOSE: To assess the effects of PDC on 30-day emergency department (ED) visits, 30-day hospital readmissions, and patient satisfaction. DATA SOURCES: MEDLINE, Embase, and CINAHL searched from 2012 to 25 May 2023. STUDY SELECTION: Randomized and nonrandomized trials of PDC within 7 days. DATA EXTRACTION: Two investigators independently screened articles and assessed risk of bias (ROB). Single reviewers extracted data, with verification by second investigators. Random-effects meta-analyses were done on outcomes shared by at least 3 studies, and the certainty of evidence was assessed using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) framework. DATA SYNTHESIS: Of 13 included studies (11 randomized trials [RTs]), 12 delivered PDCs via telephone. Three of 11 RTs were rated as having low ROB, with 1 rated high. Most PDC interventions (n = 10) consisted of single telephone contacts, often within 3 days. Eight studies focused on patients identified as higher-risk by the authors. There were no differences in 30-day ED use (5 RTs; 3054 patients; risk difference, 0.00 [95% CI, -0.02 to 0.03]; moderate certainty) or 30-day hospital readmissions (7 RTs; 7075 patients; risk difference, 0.00 [CI, -0.02 to 0.02]; moderate certainty) with PDC. LIMITATION: Adherence and fidelity to PDC interventions were poorly described, and only 1 study investigated nontelephone PDC. CONCLUSION: Postdischarge contacts within 7 days of discharge were not associated with reductions in 30-day ED use or readmissions compared with usual care. Health systems should reconsider the utility of universal PDCs because multifaceted interventions targeting higher-risk patients may be necessary to reduce use of acute care after discharge. PRIMARY FUNDING SOURCE: Department of Veterans Affairs. (PROSPERO: CRD42023465675).
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    Facets of physical function assessed by patient-reported outcome measures in oncology research.
    (Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2024-04) Coles, Theresa; Fillipo, Rebecca; Plyler, Kate; Hernandez, Alexy; Henke, Debra M; Arizmendi, Cara; Cantrell, Sarah; Lagoo-Deenadayalan, Sandhya; Rory Goodwin, C; LeBlanc, Thomas W; Horodniceanu, Erica G; Bhatnagar, Vishal; Reeve, Bryce B; Weinfurt, Kevin

    Purpose

    The U.S. Food & Drug Administration has identified physical functioning (PF) as a core patient-reported outcome (PRO) in cancer clinical trials. The purpose of this study was to identify PF PRO measures (PROMs) in adult cancer populations and classify the PROMs by content covered (facets of PF) in each measure.

    Methods

    As part of the Patient Reports of Physical Functioning Study (PROPS) research program, we conducted a targeted literature review to identify PROMs that could be used in clinical trials to evaluate PF from the patient perspective. Next, we convened an advisory panel to conduct a modified, reactive, Delphi study to reach consensus on which PF facets are assessed by PROMs identified in the review. The panel engaged in a "card sort" activity to classify PROM items by PF facets. Consensus was reached when 80% of panel members agreed that at least one facet was being measured by each PROM item.

    Results

    The literature review identified 13 PROMs that met inclusion criteria. Eight facets of PF were identified for classification in the Delphi study: ability, completion, difficulty, limitation, quality, frequency, bother, and satisfaction. Through two rounds, the panel documented and classified conceptual approaches for each PRO item presented. The most prevalent PF facets were ability, difficulty, and limitation.

    Conclusion

    Classifying PF PROMs by PF facets will promote more consistent communication regarding the aspects of PF represented in each PROM, helping researchers prioritize measures for inclusion in cancer clinical trials.
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    Optimizing the Equitable Deployment of Virtual Care for Women: Protocol for a Qualitative Evidence Synthesis Examining Patient and Provider Perspectives Supplemented with Primary Qualitative Data.
    (Health equity, 2023-01) Goldstein, Karen M; Patel, Dhara B; Van Loon, Katherine A; Shapiro, Abigail; Rushton, Sharron; Lewinski, Allison A; Lanford, Tiera J; Cantrell, Sarah; Zullig, Leah L; Wilson, Sarah M; Shepherd-Banigan, Megan; Alton Dailey, Susan; Sims, Catherine; Robinson, Cheryl; Chawla, Neetu; Bosworth, Hayden B; Hamilton, Alison; Naylor, Jennifer; Gierisch, Jennifer M

    Introduction

    Women experience numerous barriers to patient-centered health care (e.g., lack of continuity). Such barriers are amplified for women from marginalized communities. Virtual care may improve equitable access. We are conducting a partner-engaged, qualitative evidence synthesis (QES) of patients' and providers' experiences with virtual health care delivery for women.

    Methods

    We use a best-fit framework approach informed by the Non-adoption, Abandonment, Scale-up, Spread, and Sustainability framework and Public Health Critical Race Praxis. We will supplement published literature with qualitative interviews with women from underrepresented communities and their health care providers. We will engage patients and other contributors through multiple participatory methods.

    Results

    Our search identified 5525 articles published from 2010 to 2022. Sixty were eligible, of which 42 focused on women and 24 on provider experiences. Data abstraction and analysis are ongoing.

    Discussion

    This work offers four key innovations to advance health equity: (1) conceptual foundation rooted in an antiracist action-oriented praxis; (2) worked example of centering QES on marginalized communities; (3) supplementing QES with primary qualitative information with populations historically marginalized in the health care system; and (4) participatory approaches that foster longitudinal partnered engagement.

    Health equity implications

    Our approach to exploring virtual health care for women demonstrates an antiracist praxis to inform knowledge generation. In doing so, we aim to generate findings that can guide health care systems in the equitable deployment of comprehensive virtual care for women.
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    Risk of Transmitting Coronavirus Disease 2019 During Nebulizer Treatment: A Systematic Review.
    (Journal of aerosol medicine and pulmonary drug delivery, 2021-06) Goldstein, Karen M; Ghadimi, Kamrouz; Mystakelis, Harry; Kong, Yuanyuan; Meng, Tongtong; Cantrell, Sarah; Von Isenburg, Megan; Gordon, Adelaide; Ear, Belinda; Gierisch, Jennifer M; Williams, John W
    Rationale: There is an urgent need to understand the risk of viral transmission during nebulizer treatment of patients with coronavirus disease 2019 (COVID-19). Objectives: To assess the risk of transmitting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), SARS, Middle East respiratory syndrome (MERS), and influenza with administration of drugs via nebulizer. Methods: We searched multiple electronic databases, including PubMed®, China National Knowledge Infrastructure, Wanfang, preprint databases, and clinicaltrials.gov through December 1, 2020. Any study design in any language describing the risk of viral transmission with nebulizer treatment was eligible. Data were abstracted by one investigator and verified by a second. Results: We identified 22 articles: 1 systematic review, 7 cohort/case-control studies, 7 case series, and 7 simulation-based studies. Eight individual studies involved patients with SARS, five involved MERS, and one involved SARS-CoV-2. The seven cohort/case-control studies (four high risk of bias [ROB], three unclear ROB) found mixed results (median odds ratio 3.91, range 0.08-20.67) based on very weak data among a small number of health care workers (HCWs) with variable use of personal protective equipment (PPE). Case series had multiple potential contributors to transmission. Simulation studies found evidence for droplet dispersion after saline nebulization and measureable influenza viral particles up to 1.7 m from the source after 10 minutes of nebulization with a patient simulator. Study heterogeneity prevented meta-analysis. Conclusions: Case series raise concern of transmission risk, and simulation studies demonstrate droplet dispersion with virus recovery, but specific evidence that exposure to nebulizer treatment increases transmission of coronaviruses similar to COVID-19 is inconclusive. Tradeoffs balancing HCW safety and patient appropriateness can potentially minimize risk, including choice of delivery method for inhaled medications (e.g., nebulizer vs. metered dose inhaler) and PPE (e.g., N95 vs. surgical mask).