Browsing by Author "Carrillo, Luis F"
Now showing 1 - 11 of 11
- Results Per Page
- Sort Options
Item Open Access An unusual presentation of systemic mastocytosis in a myelolipoma(Blood, 2024-05-02) Carrillo, Luis F; Malaga, Milagros LItem Open Access CD10-Positive Lymphoplasmacytic Lymphoma: A Diagnostic Pitfall(Clinical Lymphoma Myeloma and Leukemia, 2024-09) Ju, Yaping; Stuart, Sophie; Zhao, Yue; Xie, Yi; Carrillo, Luis F; Siddiqi, Imran; Zhang, Ling; Wang, EndiItem Open Access Concomitant Waldenström Macroglobulinemia/Lymphoplasmacytic Lymphoma and Non-Immunoglobulin M Plasma Cell Neoplasm.(Archives of pathology & laboratory medicine, 2025-01) Zhao, Yue; Petersen, Philip; Stuart, Sophie; He, Jiaqi; Ju, Yaping; Carrillo, Luis F; Carlsen, Eric D; Xie, Yi; Ghezavati, Alireza; Siddiqi, Imran; Zhang, Ling; Wang, EndiContext.—
The co-occurrence of plasma cell neoplasm (PCN) and lymphoplasmacytic lymphoma (LPL) is rare, and their clonal relationship remains unclear.Objective.—
To evaluate the clinicopathologic characteristics of concomitant LPL/PCN.Design.—
Retrospectively analyzed clinical and laboratory data of 14 cases.Results.—
Three patients initially presented with immunoglobulin (Ig) M paraprotein, 1 with IgG paraprotein, and 10 had simultaneous diagnoses of PCN and LPL. In 13 cases, flow cytometry detected both LPL and PCN in marrow biopsies. Furthermore, immunohistochemistry highlighted the 2 neoplastic populations, demonstrating an increased proportion of plasma cells and their expression of cyclin D1, CD56, and/or a non-IgM isotype restriction. All cases exhibited discordant heavy-chain isotypes between LPL and PCN. Thirteen of the 14 cases (92.9%) had concordant light-chain restrictions between the 2 neoplasms, and the remaining case (7.1%) showed discordant light-chain restrictions. Of the 12 patients with follow-up, 5 were treated with myeloma regimens, 2 with LPL regimens, 3 with combined therapy, and 2 with observation alone. Follow-up ranged from 2 to 146 months (median, 12.5 months). One patient died of PCN progression, one died of comorbidity, and 10 patients were alive with or without disease. Survival analysis showed no significant difference from the control.Conclusions.—
The discordant heavy-chain isotype restrictions between PCN and LPL suggest biclonal B-cell neoplasms, which is supported by PCN's phenotypic distinction, such as the expression of cyclin D1 and/or CD56. However, our series exhibited a tendency toward concordant light-chain restrictions between the 2 neoplasms, raising the possibility that PCN may evolve from LPL through class switching.Item Open Access Concurrent Loss of CD16 in Granulocytes and CD14 in Mature Monocytes in a Patient With Pancytopenia: A Diagnostic Clue for Paroxysmal Nocturnal Hemoglobinuria.(Int J Lab Hematol, 2024-12-14) Prasad, Abhishek; Carlsen, Eric D; Pina-Oviedo, Sergio; Carrillo, Luis FItem Open Access Erythroblastic sarcoma in a liver biopsy.(Blood, 2024-01) Bakhshi, Tanner J; Carrillo, Luis FItem Open Access FISH-negative, karyotype-negative acute promyelocytic leukemia.(Blood, 2023-10) Malaga, Milagros L; Carrillo, Luis FItem Open Access Flow cytometry quantification of tumor-infiltrating lymphocytes to predict the survival of patients with diffuse large B-cell lymphoma(Frontiers in Immunology) Yu, Tiantian; Xu-Monette, Zijun Y; Lagoo, Anand; Shuai, Wen; Wang, Bangchen; Neff, Jadee; Carrillo, Luis F; Carlsen, Eric D; Pina-Oviedo, Sergio; Young, Ken HIntroductionOur previous studies have demonstrated that tumor-infiltrating lymphocytes (TILs), including normal B cells, T cells, and natural killer (NK) cells, in diffuse large B-cell lymphoma (DLBCL) have a significantly favorable impact on the clinical outcomes of patients treated with standard chemoimmunotherapy. In this study, to gain a full overview of the tumor immune microenvironment (TIME), we assembled a flow cytometry cohort of 102 patients diagnosed with DLBCL at the Duke University Medical Center.MethodsWe collected diagnostic flow cytometry data, including the proportion of T cells, abnormal B cells, normal B cells, plasma cells, NK cells, monocytes, and granulocytes in fresh biopsy tissues at clinical presentation, and analyzed the correlations with patient survival and between different cell populations.ResultsWe found that low T cell percentages in all viable cells and low ratios of T cells to abnormal B cells correlated with significantly poorer survival, whereas higher percentages of normal B cells among total B cells (or high ratios of normal B cells to abnormal B cells) and high percentages of NK cells among all viable cells correlated with significantly better survival in patients with DLBCL. After excluding a small number of patients with low T cell percentages, the normal B cell percentage among all B cells, but not T cell percentage among all cells, continued to show a remarkable prognostic effect. Data showed significant positive correlations between T cells and normal B cells, and between granulocytes and monocytes. Furthermore, we constructed a prognostic model based on clinical and flow cytometry factors, which divided the DLBCL cohort into two equal groups with remarkable differences in patient survival and treatment response.SummaryTILs, including normal B cells, T cells, and NK cells, are associated with favorable clinical outcomes in DLBCL, and flow cytometry capable of quantifying the TIME may have additional clinical utility for prognostication.Item Open Access Neonatal blood smear with vacuolated lymphocytes(Blood, 2024-08-08) Alexander, Catherine M; Carrillo, Luis FItem Open Access Neonatal Mimicker Cells in Cerebrospinal Fluid.(Cytopathology : official journal of the British Society for Clinical Cytology, 2024-10) Alexander, Catherine M; Carrillo, Luis FGerminal matrix cells are immature‐appearing cells that can be present in the cerebrospinal fluid of premature neonates with intraventricular hemorrhage. These cells can mimic neoplastic cells and are an important morphologic pitfall.Item Open Access Pediatric bone marrow with wrinkled histiocytes(eJHaem) Carrillo, Luis F; Alapat, DaisyItem Open Access Systemic EBV‐positive T‐cell lymphoma of childhood with unusual cytogenetic findings and family history of Still's disease‐associated recurrent macrophage activation syndrome(Pediatric Blood & Cancer) Jimenez, Adam; Carrillo, Luis F; Carlsen, Eric D