Browsing by Author "Castellanos, F Xavier"
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Item Open Access Relationship of trauma symptoms to amygdala-based functional brain changes in adolescents.(J Trauma Stress, 2013-12) Nooner, Kate B; Mennes, Maarten; Brown, Shaquanna; Castellanos, F Xavier; Leventhal, Bennett; Milham, Michael P; Colcombe, Stanley JIn this pilot study, amygdala connectivity related to trauma symptoms was explored using resting-state functional magnetic resonance imaging (R-fMRI) in 23 healthy adolescents ages 13-17 years with no psychiatric diagnoses. Adolescents completed a self-report trauma symptom checklist and a R-fMRI scan. We examined the relationship of trauma symptoms to resting-state functional connectivity of the amygdala. Increasing self-report of trauma symptoms by adolescents was associated with increasing functional connectivity with the right amygdala and a local limbic cluster and decreasing functional connectivity with the amygdala and a long-range frontoparietal cluster to the left amygdala, which can be a hallmark of immaturity. These pilot findings in adolescents provide preliminary evidence that even mild trauma symptoms can be linked to the configuration of brain networks associated with the amygdala.