Browsing by Author "Chen, J"
Now showing 1 - 4 of 4
Results Per Page
Sort Options
Item Open Access Analysis of the divide-and-conquer method for electronic structure calculations(2017-04-26) Chen, J; Lu, JWe study the accuracy of the divide-and-conquer method for electronic structure calculations. The analysis is conducted for a prototypical subdomain problem in the method. We prove that the pointwise difference between electron densities of the global system and the subsystem decays exponentially as a function of the distance away from the boundary of the subsystem, under the gap assumption of both the global system and the subsystem. We show that gap assumption is crucial for the accuracy of the divide-and-conquer method by numerical examples. In particular, we show examples with the loss of accuracy when the gap assumption of the subsystem is invalid.Item Open Access Carrier Dynamics Engineering for High-Performance Electron-Transport-Layer-free Perovskite Photovoltaics(CHEM, 2018-10-11) Han, Q; Ding, J; Bai, Y; Li, T; Ma, JY; Chen, YX; Zhou, Y; Liu, J; Ge, QQ; Chen, J; Glass, JT; Therien, MJ; Liu, J; Mitzi, DB; Hu, JSItem Open Access Integrin-mediated interactions with extracellular matrix proteins for nucleus pulposus cells of the human intervertebral disc.(J Orthop Res, 2013-10) Bridgen, DT; Gilchrist, CL; Richardson, WJ; Isaacs, RE; Brown, CR; Yang, KL; Chen, J; Setton, LAThe extracellular matrix (ECM) of the human intervertebral disc is rich in molecules that interact with cells through integrin-mediated attachments. Porcine nucleus pulposus (NP) cells have been shown to interact with laminin (LM) isoforms LM-111 and LM-511 through select integrins that regulate biosynthesis and cell attachment. Since human NP cells lose many phenotypic characteristics with age, attachment and interaction with the ECM may be altered. Expression of LM-binding integrins was quantified for human NP cells using flow cytometry. The cell-ECM attachment mechanism was determined by quantifying cell attachment to LM-111, LM-511, or type II collagen after functionally blocking specific integrin subunits. Human NP cells express integrins β1, α3, and α5, with over 70% of cells positive for each subunit. Blocking subunit β1 inhibited NP cell attachment to all substrates. Blocking subunits α1, α2, α3, and α5 simultaneously, but not individually, inhibits NP cell attachment to laminins. While integrin α6β1 mediated porcine NP cell attachment to LM-111, we found integrins α3, α5, and β1 instead contributed to human NP cell attachment. These findings identify integrin subunits that may mediate interactions with the ECM for human NP cells and could be used to promote cell attachment, survival, and biosynthesis in cell-based therapeutics.Item Open Access Shrinkage estimation for robust and efficient screening of single-SNP association from case-control genome-wide association studies(Genetic Epidemiology, 2009-12) Luo, S; Mukherjee, B; Chen, J; Chatterjee, N