Browsing by Author "Chen, Jian"
Now showing 1 - 3 of 3
- Results Per Page
- Sort Options
Item Open Access ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries.(Translational psychiatry, 2020-03) Thompson, Paul M; Jahanshad, Neda; Ching, Christopher RK; Salminen, Lauren E; Thomopoulos, Sophia I; Bright, Joanna; Baune, Bernhard T; Bertolín, Sara; Bralten, Janita; Bruin, Willem B; Bülow, Robin; Chen, Jian; Chye, Yann; Dannlowski, Udo; de Kovel, Carolien GF; Donohoe, Gary; Eyler, Lisa T; Faraone, Stephen V; Favre, Pauline; Filippi, Courtney A; Frodl, Thomas; Garijo, Daniel; Gil, Yolanda; Grabe, Hans J; Grasby, Katrina L; Hajek, Tomas; Han, Laura KM; Hatton, Sean N; Hilbert, Kevin; Ho, Tiffany C; Holleran, Laurena; Homuth, Georg; Hosten, Norbert; Houenou, Josselin; Ivanov, Iliyan; Jia, Tianye; Kelly, Sinead; Klein, Marieke; Kwon, Jun Soo; Laansma, Max A; Leerssen, Jeanne; Lueken, Ulrike; Nunes, Abraham; Neill, Joseph O'; Opel, Nils; Piras, Fabrizio; Piras, Federica; Postema, Merel C; Pozzi, Elena; Shatokhina, Natalia; Soriano-Mas, Carles; Spalletta, Gianfranco; Sun, Daqiang; Teumer, Alexander; Tilot, Amanda K; Tozzi, Leonardo; van der Merwe, Celia; Van Someren, Eus JW; van Wingen, Guido A; Völzke, Henry; Walton, Esther; Wang, Lei; Winkler, Anderson M; Wittfeld, Katharina; Wright, Margaret J; Yun, Je-Yeon; Zhang, Guohao; Zhang-James, Yanli; Adhikari, Bhim M; Agartz, Ingrid; Aghajani, Moji; Aleman, André; Althoff, Robert R; Altmann, Andre; Andreassen, Ole A; Baron, David A; Bartnik-Olson, Brenda L; Marie Bas-Hoogendam, Janna; Baskin-Sommers, Arielle R; Bearden, Carrie E; Berner, Laura A; Boedhoe, Premika SW; Brouwer, Rachel M; Buitelaar, Jan K; Caeyenberghs, Karen; Cecil, Charlotte AM; Cohen, Ronald A; Cole, James H; Conrod, Patricia J; De Brito, Stephane A; de Zwarte, Sonja MC; Dennis, Emily L; Desrivieres, Sylvane; Dima, Danai; Ehrlich, Stefan; Esopenko, Carrie; Fairchild, Graeme; Fisher, Simon E; Fouche, Jean-Paul; Francks, Clyde; Frangou, Sophia; Franke, Barbara; Garavan, Hugh P; Glahn, David C; Groenewold, Nynke A; Gurholt, Tiril P; Gutman, Boris A; Hahn, Tim; Harding, Ian H; Hernaus, Dennis; Hibar, Derrek P; Hillary, Frank G; Hoogman, Martine; Hulshoff Pol, Hilleke E; Jalbrzikowski, Maria; Karkashadze, George A; Klapwijk, Eduard T; Knickmeyer, Rebecca C; Kochunov, Peter; Koerte, Inga K; Kong, Xiang-Zhen; Liew, Sook-Lei; Lin, Alexander P; Logue, Mark W; Luders, Eileen; Macciardi, Fabio; Mackey, Scott; Mayer, Andrew R; McDonald, Carrie R; McMahon, Agnes B; Medland, Sarah E; Modinos, Gemma; Morey, Rajendra A; Mueller, Sven C; Mukherjee, Pratik; Namazova-Baranova, Leyla; Nir, Talia M; Olsen, Alexander; Paschou, Peristera; Pine, Daniel S; Pizzagalli, Fabrizio; Rentería, Miguel E; Rohrer, Jonathan D; Sämann, Philipp G; Schmaal, Lianne; Schumann, Gunter; Shiroishi, Mark S; Sisodiya, Sanjay M; Smit, Dirk JA; Sønderby, Ida E; Stein, Dan J; Stein, Jason L; Tahmasian, Masoud; Tate, David F; Turner, Jessica A; van den Heuvel, Odile A; van der Wee, Nic JA; van der Werf, Ysbrand D; van Erp, Theo GM; van Haren, Neeltje EM; van Rooij, Daan; van Velzen, Laura S; Veer, Ilya M; Veltman, Dick J; Villalon-Reina, Julio E; Walter, Henrik; Whelan, Christopher D; Wilde, Elisabeth A; Zarei, Mojtaba; Zelman, Vladimir; ENIGMA ConsortiumThis review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease. Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide data and expertise to answer fundamental questions in neuroscience, psychiatry, neurology, and genetics. Most ENIGMA WGs focus on specific psychiatric and neurological conditions, other WGs study normal variation due to sex and gender differences, or development and aging; still other WGs develop methodological pipelines and tools to facilitate harmonized analyses of "big data" (i.e., genetic and epigenetic data, multimodal MRI, and electroencephalography data). These international efforts have yielded the largest neuroimaging studies to date in schizophrenia, bipolar disorder, major depressive disorder, post-traumatic stress disorder, substance use disorders, obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, autism spectrum disorders, epilepsy, and 22q11.2 deletion syndrome. More recent ENIGMA WGs have formed to study anxiety disorders, suicidal thoughts and behavior, sleep and insomnia, eating disorders, irritability, brain injury, antisocial personality and conduct disorder, and dissociative identity disorder. Here, we summarize the first decade of ENIGMA's activities and ongoing projects, and describe the successes and challenges encountered along the way. We highlight the advantages of collaborative large-scale coordinated data analyses for testing reproducibility and robustness of findings, offering the opportunity to identify brain systems involved in clinical syndromes across diverse samples and associated genetic, environmental, demographic, cognitive, and psychosocial factors.Item Open Access Interleukin 17–producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice(Nature Immunology, 2008-02) Hsu, Hui-Chen; Yang, PingAr; Wang, John; Wu, Qi; Myers, Riley; Chen, Jian; Yi, John; Guentert, Tanja; Tousson, Albert; Stanus, Andrea L; Le, Thuc-vy L; Lorenz, Robin G; Xu, Hui; Kolls, Jay K; Carter, Robert H; Chaplin, David D; Williams, Robert W; Mountz, John DItem Open Access Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling.(Nature, 2015-09) Zhang, Feng; Yao, Jian; Ke, Jiyuan; Zhang, Li; Lam, Vinh Q; Xin, Xiu-Fang; Zhou, X Edward; Chen, Jian; Brunzelle, Joseph; Griffin, Patrick R; Zhou, Mingguo; Xu, H Eric; Melcher, Karsten; He, Sheng YangThe plant hormone jasmonate plays crucial roles in regulating plant responses to herbivorous insects and microbial pathogens and is an important regulator of plant growth and development. Key mediators of jasmonate signalling include MYC transcription factors, which are repressed by jasmonate ZIM-domain (JAZ) transcriptional repressors in the resting state. In the presence of active jasmonate, JAZ proteins function as jasmonate co-receptors by forming a hormone-dependent complex with COI1, the F-box subunit of an SCF-type ubiquitin E3 ligase. The hormone-dependent formation of the COI1-JAZ co-receptor complex leads to ubiquitination and proteasome-dependent degradation of JAZ repressors and release of MYC proteins from transcriptional repression. The mechanism by which JAZ proteins repress MYC transcription factors and how JAZ proteins switch between the repressor function in the absence of hormone and the co-receptor function in the presence of hormone remain enigmatic. Here we show that Arabidopsis MYC3 undergoes pronounced conformational changes when bound to the conserved Jas motif of the JAZ9 repressor. The Jas motif, previously shown to bind to hormone as a partly unwound helix, forms a complete α-helix that displaces the amino (N)-terminal helix of MYC3 and becomes an integral part of the MYC N-terminal fold. In this position, the Jas helix competitively inhibits MYC3 interaction with the MED25 subunit of the transcriptional Mediator complex. Our structural and functional studies elucidate a dynamic molecular switch mechanism that governs the repression and activation of a major plant hormone pathway.