Browsing by Author "Cheungpasitporn, Wisit"
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Item Open Access Acute Kidney Injury after Lung Transplantation: A Systematic Review and Meta-Analysis.(Journal of clinical medicine, 2019-10) Lertjitbanjong, Ploypin; Thongprayoon, Charat; Cheungpasitporn, Wisit; O'Corragain, Oisín A; Srivali, Narat; Bathini, Tarun; Watthanasuntorn, Kanramon; Aeddula, Narothama Reddy; Salim, Sohail Abdul; Ungprasert, Patompong; Gillaspie, Erin A; Wijarnpreecha, Karn; Mao, Michael A; Kaewput, WisitLung transplantation has been increasingly performed worldwide and is considered an effective therapy for patients with various causes of end-stage lung diseases. We performed a systematic review to assess the incidence and impact of acute kidney injury (AKI) and severe AKI requiring renal replacement therapy (RRT) in patients after lung transplantation. A literature search was conducted utilizing Ovid MEDLINE, EMBASE, and Cochrane Database from inception through June 2019. We included studies that evaluated the incidence of AKI, severe AKI requiring RRT, and mortality risk of AKI among patients after lung transplantation. Pooled incidence and odds ratios (ORs) with 95% confidence interval (CI) were obtained using random-effects meta-analysis. The protocol for this meta-analysis is registered with PROSPERO (International Prospective Register of Systematic Reviews; no. CRD42019134095). A total of 26 cohort studies with a total of 40,592 patients after lung transplantation were enrolled. Overall, the pooled estimated incidence rates of AKI (by standard AKI definitions) and severe AKI requiring RRT following lung transplantation were 52.5% (95% CI: 45.8-59.1%) and 9.3% (95% CI: 7.6-11.4%). Meta-regression analysis demonstrated that the year of study did not significantly affect the incidence of AKI (p = 0.22) and severe AKI requiring RRT (p = 0.68). The pooled ORs of in-hospital mortality in patients after lung transplantation with AKI and severe AKI requiring RRT were 2.75 (95% CI, 1.18-6.41) and 10.89 (95% CI, 5.03-23.58). At five years, the pooled ORs of mortality among patients after lung transplantation with AKI and severe AKI requiring RRT were 1.47 (95% CI, 1.11-1.94) and 4.79 (95% CI, 3.58-6.40), respectively. The overall estimated incidence rates of AKI and severe AKI requiring RRT in patients after lung transplantation are 52.5% and 9.3%, respectively. Despite advances in therapy, the incidence of AKI in patients after lung transplantation does not seem to have decreased. In addition, AKI after lung transplantation is significantly associated with reduced short-term and long-term survival.Item Open Access Assessing the impact of continuous positive airway pressure therapy on clinical outcomes in interstitial lung disease patients with coexisting obstructive sleep apnea: a systematic review.(Sleep Breath, 2024-05-08) Srivali, Narat; Thongprayoon, Charat; Cheungpasitporn, WisitPURPOSE: Interstitial lung disease (ILD) often coexists with obstructive sleep apnea (OSA), contributing to increased morbidity and mortality. However, the effectiveness of continuous positive airway pressure (CPAP) therapy in this population remains unclear. We conducted a systematic review to evaluate CPAP therapy's impact on clinical outcomes in patients with ILD and comorbid OSA. METHODS: Following PRISMA guidelines, we systematically searched multiple databases for studies assessing CPAP therapy's effects on ILD exacerbation, hospitalization, quality of life, and mortality in ILD-OSA patients. Studies were selected based on predefined inclusion criteria, and their quality was assessed using the Newcastle-Ottawa quality scale. RESULTS: Among 485 articles screened, 82 underwent full review, with four observational studies meeting inclusion criteria. CPAP therapy demonstrated potential benefits in improving quality of life and reducing ILD exacerbations in ILD-OSA patients. However, its impact on mortality was inconclusive due to variability in study definitions and methodology. CONCLUSION: CPAP therapy may improve outcomes in ILD-OSA patients, particularly in terms of quality of life and ILD exacerbations. Nonetheless, further research with standardized definitions and rigorous methodology is needed to confirm its efficacy, particularly regarding mortality outcome.Item Open Access CHANGING TRENDS IN THE USE OF VASOPRESSORS IN INTENSIVE CARE UNIT: A 7-YEAR STUDY(Critical Care Medicine, 2014-12) Srivali, Narat; Thongprayoon, Charat; Kittanamongkolchai, Wonngarm; Cheungpasitporn, Wisit; Erdogan, Aysen; Carrera, Perliveh; Kashani, KianoushLearning Objectives: The use of vasopressors was common in intensive care unit (ICU). Due to the lack of conclusive evidence in superiority in efficacy among various types of vasopressors, the choice of vasopressor use mainly depends on the physician preference. This study aims to describe the prevalence of vasopressor use and the trend in the use of each vasopressor medication in ICU over the past 7 years. Methods: This is a descriptive study conducted at a tertiary referral hospital. All ICU admissions, including both medical and surgical ICU, at our institution between January 2007 and December 2013 were included in this study. The use of vasopressors within given ICU day (12.00 am – 11.59 pm) during ICU stay was reviewed. Vasopressors were defined as the continuous intravenous administration of norepinephrine, epinephrine, dopamine, phenylephrine, or vasopressin regardless of duration and dosage. Results: A total of 52410 unique patients had 72005 ICU admissions in the course of study, (272271 patient*ICU day). Vasopressors were used in 17767 (24.7%) ICU admissions and on 53898 (19.8%) patient*ICU day, resulting in a total of 76564 vasopressor day. Vasopressin was used on 21955 (41%), epinephrine on 20958 (39%), norepinephrine on 17919 (33%), dopamine on 8636 (16%) and phenylephrine on 7096 (13%) patient*ICU day. Over 2007-2013, there was an upward trend in the use of norepinephrine (the proportion of ICU day on norepinephrine over total ICU day with vasopressor 0.24 in year 2007 to 0.45 in year 2013), and a downward trend in phenylephrine (the proportion of ICU day on phenylephrine over total ICU day with vasopressor 0.20 in year 2007 to 0.10 in year 2013). There was no specific trend in the usage of vasopressin, epinephrine, and dopamine. Conclusions: The vasopressors were used in about one fourth of ICU admission and about one fifth of ICU days. Vasopressin is the most commonly used vasopressor. The use of norepinephrine is in upward trajectory.Item Open Access HYDRATION FOR CONTRAST-INDUCED ACUTE KIDNEY INJURY PREVENTION A META-ANALYSIS(Critical Care Medicine, 2014-12-01) Srivali, Narat; Cheungpasitporn, Wisit; Charat, Thongprayoon; Edmonds, Peter; O’Corragain, Oisin; Kittanamongkolchai, Wonngarm; Brabec, Brady; Erickson, StephenLearning Objectives: The reports on efficacy of oral hydration compared to intravenous hydration for the prevention of contrast-induced acute kidney injury (CIAKI) in radiological procedures and cardiac catheterization remains controversial. The objective of this meta-analysis was to assess the efficacy of these hydration regimens for prevention of CIAKI. Methods: Comprehensive literature searches for randomized controlled trials (RCTs) of outpatient oral hydration treatment was performed using MEDLINE, EMBASE, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials Systematic Reviews and clinicaltrials.gov from inception until July 4th, 2014. Primary outcome was the incidence of CIAKI. Results: Three prospective RCTs were included in our analysis. Of 242 patients undergoing procedures with contrast exposures, 22 patients (9%) had CIAKI. These 3 RCTs, however, included only patients with relatively normal kidney function to CKD stage 3 and excluded those who had contrast exposure for urgent indications. There was no significant increased risk of CIAKI in oral fluid regimen group compared to IV fluid regimen group (RR = 1.83, 95% CI = 0.41–8.21). Conclusions: According to our analysis, there is no evidence that oral fluid regimen is associated with more risk of CIAKI in patients with contrast exposures compared to IV fluid regimen. This finding suggests that the oral fluid regimen is a possible treatment option for CIAKI prevention in non-urgent procedures in patients with normal to moderately reduced kidney function.Item Open Access Impact of ANCA-Associated Vasculitis on Outcomes of Hospitalizations for Goodpasture's Syndrome in the United States: Nationwide Inpatient Sample 2003-2014.(Medicina (Kaunas, Lithuania), 2020-03) Thongprayoon, Charat; Kaewput, Wisit; Boonpheng, Boonphiphop; Ungprasert, Patompong; Bathini, Tarun; Srivali, Narat; Vallabhajosyula, Saraschandra; Castaneda, Jorge L; Monga, Divya; Kanduri, Swetha R; Medaura, Juan; Cheungpasitporn, WisitBackground and objectives: Goodpasture's syndrome (GS) is a rare, life-threatening autoimmune disease. Although the coexistence of anti-neutrophil cytoplasmic antibody (ANCA) with Goodpasture's syndrome has been recognized, the impacts of ANCA vasculitis on mortality and resource utilization among patients with GS are unclear. Materials and Methods: We used the National Inpatient Sample to identify hospitalized patients with a principal diagnosis of GS from 2003 to 2014 in the database. The predictor of interest was the presence of ANCA-associated vasculitis. We tested the differences concerning in-hospital treatment and outcomes between GS patients with and without ANCA-associated vasculitis using logistic regression analysis with adjustment for other clinical characteristics. Results: A total of 964 patients were primarily admitted to hospital for GS. Of these, 84 (8.7%) had a concurrent diagnosis of ANCA-associated vasculitis. Hemoptysis was more prevalent in GS patients with ANCA-associated vasculitis. During hospitalization, GS patients with ANCA-associated required non-significantly more mechanical ventilation and non-invasive ventilation support, but non-significantly less renal replacement therapy and plasmapheresis than those with GS alone. There was no significant difference in in-hospital outcomes, including organ failure and mortality, between GS patients with and without ANCA-associated vasculitis. Conclusions: Our study demonstrated no significant differences between resource utilization and in-hospital mortality among hospitalized patients with coexistence of ANCA vasculitis and GS, compared to those with GS alone.Item Open Access Incidence and Impact of Acute Kidney Injury in Patients Receiving Extracorporeal Membrane Oxygenation: A Meta-Analysis.(Journal of clinical medicine, 2019-07) Thongprayoon, Charat; Cheungpasitporn, Wisit; Lertjitbanjong, Ploypin; Aeddula, Narothama Reddy; Bathini, Tarun; Watthanasuntorn, Kanramon; Srivali, Narat; Mao, Michael A; Kashani, KianoushAlthough acute kidney injury (AKI) is a frequent complication in patients receiving extracorporeal membrane oxygenation (ECMO), the incidence and impact of AKI on mortality among patients on ECMO remain unclear. We conducted this systematic review to summarize the incidence and impact of AKI on mortality risk among adult patients on ECMO. A literature search was performed using EMBASE, Ovid MEDLINE, and Cochrane Databases from inception until March 2019 to identify studies assessing the incidence of AKI (using a standard AKI definition), severe AKI requiring renal replacement therapy (RRT), and the impact of AKI among adult patients on ECMO. Effect estimates from the individual studies were obtained and combined utilizing random-effects, generic inverse variance method of DerSimonian-Laird. The protocol for this systematic review is registered with PROSPERO (no. CRD42018103527). 41 cohort studies with a total of 10,282 adult patients receiving ECMO were enrolled. Overall, the pooled estimated incidence of AKI and severe AKI requiring RRT were 62.8% (95%CI: 52.1%-72.4%) and 44.9% (95%CI: 40.8%-49.0%), respectively. Meta-regression showed that the year of study did not significantly affect the incidence of AKI (p = 0.67) or AKI requiring RRT (p = 0.83). The pooled odds ratio (OR) of hospital mortality among patients receiving ECMO with AKI on RRT was 3.73 (95% CI, 2.87-4.85). When the analysis was limited to studies with confounder-adjusted analysis, increased hospital mortality remained significant among patients receiving ECMO with AKI requiring RRT with pooled OR of 3.32 (95% CI, 2.21-4.99). There was no publication bias as evaluated by the funnel plot and Egger's regression asymmetry test with p = 0.62 and p = 0.17 for the incidence of AKI and severe AKI requiring RRT, respectively. Among patients receiving ECMO, the incidence rates of AKI and severe AKI requiring RRT are high, which has not changed over time. Patients who develop AKI requiring RRT while on ECMO carry 3.7-fold higher hospital mortality.Item Open Access Inpatient Burden and Mortality of Goodpasture's Syndrome in the United States: Nationwide Inpatient Sample 2003-2014.(Journal of clinical medicine, 2020-02) Kaewput, Wisit; Thongprayoon, Charat; Boonpheng, Boonphiphop; Ungprasert, Patompong; Bathini, Tarun; Chewcharat, Api; Srivali, Narat; Vallabhajosyula, Saraschandra; Cheungpasitporn, WisitBackground: Goodpasture's syndrome is a rare, life-threatening, small vessel vasculitis. Given its rarity, data on its inpatient burden and resource utilization are lacking. We conducted this study aiming to assess inpatient prevalence, mortality, and resource utilization of Goodpasture's syndrome in the United States. Methods: The 2003-2014 National Inpatient Sample was used to identify patients with a principal diagnosis of Goodpasture's syndrome. The inpatient prevalence, clinical characteristics, in-hospital treatment, end-organ failure, mortality, length of hospital stay, and hospitalization cost were studied. Multivariable logistic regression was performed to identify independent factors associated with in-hospital mortality. Results: A total of 964 patients were admitted in hospital with Goodpasture's syndrome as the principal diagnosis, accounting for an overall inpatient prevalence of Goodpasture's syndrome among hospitalized patients in the United States of 10.3 cases per 1,000,000 admissions. The mean age of patients was 54 ± 21 years, and 47% were female; 52% required renal replacement therapy, whereas 39% received plasmapheresis during hospitalization. Furthermore, 78% had end-organ failure, with renal failure and respiratory failure being the two most common end-organ failures. The in-hospital mortality rate was 7.7 per 100 admissions. The factors associated with increased in-hospital mortality were age older than 70 years, sepsis, the development of respiratory failure, circulatory failure, renal failure, and liver failure, whereas the factors associated with decreased in-hospital mortality were more recent year of hospitalization and the use of therapeutic plasmapheresis. The median length of hospital stay was 10 days. The median hospitalization cost was $75,831. Conclusion: The inpatient prevalence of Goodpasture's syndrome in the United States is 10.3 cases per 1,000,000 admissions. Hospitalization of patients with Goodpasture's syndrome was associated with high hospital inpatient utilization and costs.Item Open Access Machine Learning Consensus Clustering Approach for Patients with Lactic Acidosis in Intensive Care Units.(Journal of personalized medicine, 2021-11) Pattharanitima, Pattharawin; Thongprayoon, Charat; Petnak, Tananchai; Srivali, Narat; Gembillo, Guido; Kaewput, Wisit; Chesdachai, Supavit; Vallabhajosyula, Saraschandra; O'Corragain, Oisin A; Mao, Michael A; Garovic, Vesna D; Qureshi, Fawad; Dillon, John J; Cheungpasitporn, WisitLactic acidosis is a heterogeneous condition with multiple underlying causes and associated outcomes. The use of multi-dimensional patient data to subtype lactic acidosis can personalize patient care. Machine learning consensus clustering may identify lactic acidosis subgroups with unique clinical profiles and outcomes. We used the Medical Information Mart for Intensive Care III database to abstract electronic medical record data from patients admitted to intensive care units (ICU) in a tertiary care hospital in the United States. We included patients who developed lactic acidosis (defined as serum lactate ≥ 4 mmol/L) within 48 h of ICU admission. We performed consensus clustering analysis based on patient characteristics, comorbidities, vital signs, organ supports, and laboratory data to identify clinically distinct lactic acidosis subgroups. We calculated standardized mean differences to show key subgroup features. We compared outcomes among subgroups. We identified 1919 patients with lactic acidosis. The algorithm revealed three best unique lactic acidosis subgroups based on patient variables. Cluster 1 (n = 554) was characterized by old age, elective admission to cardiac surgery ICU, vasopressor use, mechanical ventilation use, and higher pH and serum bicarbonate. Cluster 2 (n = 815) was characterized by young age, admission to trauma/surgical ICU with higher blood pressure, lower comorbidity burden, lower severity index, and less vasopressor use. Cluster 3 (n = 550) was characterized by admission to medical ICU, history of liver disease and coagulopathy, acute kidney injury, lower blood pressure, higher comorbidity burden, higher severity index, higher serum lactate, and lower pH and serum bicarbonate. Cluster 3 had the worst outcomes, while cluster 1 had the most favorable outcomes in terms of persistent lactic acidosis and mortality. Consensus clustering analysis synthesized the pattern of clinical and laboratory data to reveal clinically distinct lactic acidosis subgroups with different outcomes.Item Open Access Machine Learning Prediction Models for Mortality in Intensive Care Unit Patients with Lactic Acidosis.(Journal of clinical medicine, 2021-10) Pattharanitima, Pattharawin; Thongprayoon, Charat; Kaewput, Wisit; Qureshi, Fawad; Qureshi, Fahad; Petnak, Tananchai; Srivali, Narat; Gembillo, Guido; O'Corragain, Oisin A; Chesdachai, Supavit; Vallabhajosyula, Saraschandra; Guru, Pramod K; Mao, Michael A; Garovic, Vesna D; Dillon, John J; Cheungpasitporn, WisitLactic acidosis is the most common cause of anion gap metabolic acidosis in the intensive care unit (ICU), associated with poor outcomes including mortality. We sought to compare machine learning (ML) approaches versus logistic regression analysis for prediction of mortality in lactic acidosis patients admitted to the ICU. We used the Medical Information Mart for Intensive Care (MIMIC-III) database to identify ICU adult patients with lactic acidosis (serum lactate ≥4 mmol/L). The outcome of interest was hospital mortality. We developed prediction models using four ML approaches consisting of random forest (RF), decision tree (DT), extreme gradient boosting (XGBoost), artificial neural network (ANN), and statistical modeling with forward stepwise logistic regression using the testing dataset. We then assessed model performance using area under the receiver operating characteristic curve (AUROC), accuracy, precision, error rate, Matthews correlation coefficient (MCC), F1 score, and assessed model calibration using the Brier score, in the independent testing dataset. Of 1919 lactic acidosis ICU patients, 1535 and 384 were included in the training and testing dataset, respectively. Hospital mortality was 30%. RF had the highest AUROC at 0.83, followed by logistic regression 0.81, XGBoost 0.81, ANN 0.79, and DT 0.71. In addition, RF also had the highest accuracy (0.79), MCC (0.45), F1 score (0.56), and lowest error rate (21.4%). The RF model was the most well-calibrated. The Brier score for RF, DT, XGBoost, ANN, and multivariable logistic regression was 0.15, 0.19, 0.18, 0.19, and 0.16, respectively. The RF model outperformed multivariable logistic regression model, SOFA score (AUROC 0.74), SAP II score (AUROC 0.77), and Charlson score (AUROC 0.69). The ML prediction model using RF algorithm provided the highest predictive performance for hospital mortality among ICU patient with lactic acidosis.Item Open Access Off-pump versus on-pump coronary artery bypass surgery: an updated meta-analysis of randomized controlled trials on acute kidney injury and mortality outcomes(Journal of the American College of Cardiology) Spanuchart, Ittikorn; Cheungpasitporn, Wisit; Thongprayoon, Charat; Ratanapo, Supawat; Srivali, NaratBackground: The risk of acute kidney injury (AKI) in patients undergoing coronary artery bypass surgery (CABG) with on-pump and off-pump techniques for ischemic heart disease is controversial. The objective of this meta-analysis was to compare these two techniques with respect to causing AKI. Methods: Comprehensive literature searches for randomized controlled trials (RCTs) of CABG with on-pump and off-pump was performed using MEDLINE, EMBASE, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials Systematic Reviews and clinicaltrials.gov from inception through August 2014. Primary outcome was the incidence of AKI. Results: Thirty one prospective RCTs (11,851 patients) were included in our analysis. By meta-analysis, patients in off-pump CABG group had overall lower incidence of AKI (19.1%) compared to on-pump CABG group (22.2%). There was a significant protective effect of off-pump CABG on the incidence of AKI compared to on-pump CABG group [risk ratios (RR): 0.87; 95% CI: 0.77-0.98, I2 of 5%]. The post hoc analysis assessing the mortality outcome demonstrated pooled RR of 0.97 (95% CI, 0.77-1.23) in off-pump vs on-pump CABGs. Conclusion: Our study demonstrates significantly beneficial effect of off-pump CABG on the incidence of AKI compared to conventional on-pump CABG. However, our meta-analysis does not show survival benefit among patients undergoing CABG.Item Open Access Periodic limb movements during sleep and hypertension: A systematic review and meta-analysis(Sleep, 2023-05-29) Srivali, Narat; Thongprayoon, Charat; Tangpanithandee, Supawit; Krisanapan, Pajaree; Zinchuk, Andrey; Koo, Brain; Cheungpasitporn, WisitIntroduction Several studies suggest an association between periodic limb movements during sleep (PLMS) and hypertension; however, a systematic evaluation of this relationship is lacking. Methods We conducted a systematic review and meta-analysis of observational studies that reported odds ratio, relative risk, hazard ratio, or standardized incidence ratio, comparing the risk of hypertension in persons with PLMS (defined by the level of periodic limb movements per hour of sleep depended on individual studies) versus those without PLMS. After assessing heterogeneity and bias, the pooled risk ratio and 95% confidence intervals (CIs) were determined using a random-effect, generic inverse variance method of DerSimonian and Laird. Results Out of 572 potentially relevant articles, six eligible cross-sectional studies were included in the data analysis which included 8,949 participants. The statistical heterogeneity of this study was insignificant, with an I2 of 0%. A funnel plot showed no publication bias. The pooled risk ratio of hypertension in patients with PLMS was 1.26 (95% CI, 1.12–1.41). Conclusion Our analysis demonstrates an increased hypertension risk among patients with PLMS. Prospective or interventional studies are needed to confirm this association.Item Open Access Periodic limb movements during sleep and risk of hypertension: A systematic review.(Sleep medicine, 2023-02) Srivali, Narat; Thongprayoon, Charat; Tangpanithandee, Supawit; Krisanapan, Pajaree; Mao, Michael A; Zinchuk, Andrey; Koo, Brain B; Cheungpasitporn, WisitBackground
Several studies suggest an association between periodic limb movements during sleep (PLMS) and hypertension; however, a systematic evaluation of this relationship is lacking.Methods
We conducted a systematic review and meta-analysis of observational studies that reported odds ratio, relative risk, hazard ratio, or standardized incidence ratio, comparing the risk of hypertension in persons with PLMS (defined by the level of periodic limb movements per hour of sleep depended on individual studies) versus those without PLMS. After assessing heterogeneity and bias, the pooled risk ratio and 95% confidence intervals (CIs) were determined using a random-effect, generic inverse variance method of DerSimonian and Laird.Results
Out of 572 potentially relevant articles, six eligible studies were included in the data analysis. Studies (6 cross-sectional) included 8949 participants. The statistical heterogeneity of this study was insignificant, with an I2 of 0%. A funnel plot and Egger's regression asymmetry test showed no publication bias with P-value ≥0.05. The pooled risk ratio of hypertension in patients with PLMS was 1.26 (95% CI, 1.12-1.41).Conclusions
Our analysis demonstrates an increased hypertension risk among patients with PLMS. Prospective or interventional studies are needed to confirm this association.Item Open Access Temporal trends in the utilization of vasopressors in intensive care units: an epidemiologic study.(BMC pharmacology & toxicology, 2016-05) Thongprayoon, Charat; Cheungpasitporn, Wisit; Harrison, Andrew M; Carrera, Perliveh; Srivali, Narat; Kittamongkolchai, Wonngarm; Erdogan, Aysen; Kashani, Kianoush BBackground
The choice of vasopressor use in the intensive care unit (ICU) depends primarily on provider preference. This study aims to describe the rate of vasopressor utilization and the trends of each vasoactive agent usage in the ICU over the span of 7 years in a tertiary referral center.Methods
All adult ICU admissions, including medical, cardiac, and surgical ICUs from January 1st, 2007 through December 31st, 2013 were included in this study. Vasopressor use was defined as the continuous intravenous administration of epinephrine, norepinephrine, phenylephrine, dopamine, or vasopressin within a given ICU day. The vasopressor utilization index (VUI) was defined as the proportion of ICU days on each vasoactive agent divided by the total ICU days with vasopressor usage.Results
During the study period, 72,005 ICU admissions and 272,271 ICU days were screened. Vasopressors were used in 19,575 ICU admissions (27 %) and 59,811 ICU days (22 %). Vasopressin was used in 24,496 (41 %), epinephrine in 23,229 (39 %), norepinephrine in 20,648 (34 %), dopamine in 9449 (16 %), and phenylephrine in 7508 (13 %) ICU days. The VUInorepinephrine increased from 0.24 in 2007 to 0.46 in 2013 and VUIphenylephrine decreased from 0.20 in 2007 to 0.08 in 2013 (p < 0.001 both). For epinephrine, dopamine, and vasopressin VUI did not change over the course of study.Conclusion
Vasopressors were used in about one fourth of ICU admissions and about one-fifth of ICU days. Although vasopressin is the most commonly used vasopressor, the use of norepinephrine found to have an increasing trajectory.Item Open Access The association between renal recovery after acute kidney injury and long-term mortality after transcatheter aortic valve replacement.(PloS one, 2017-01) Thongprayoon, Charat; Cheungpasitporn, Wisit; Srivali, Narat; Kittanamongkolchai, Wonngarm; Sakhuja, Ankit; Greason, Kevin L; Kashani, Kianoush BBackground
This study aimed to examine the association between renal recovery status at hospital discharge after acute kidney injury (AKI) and long-term mortality following transcatheter aortic valve replacement (TAVR).Methods
We screened all adult patients who survived to hospital discharge after TAVR for aortic stenosis at a quaternary referral medical center from January 1, 2008, through June 30, 2014. An AKI was defined as an increase in serum creatinine level of 0.3 mg/dL or a relative increase of 50% from baseline. Renal outcome at the time of discharge was evaluated by comparing the discharge serum creatinine level to the baseline level. Complete renal recovery was defined as no AKI at discharge, whereas partial renal recovery was defined as AKI without a need for renal replacement therapy at discharge. No renal recovery was defined as a need for renal replacement therapy at discharge.Results
The study included 374 patients. Ninty-eight (26%) patients developed AKI during hospitalization: 55 (56%) had complete recovery; 39 (40%), partial recovery; and 4 (4%), no recovery. AKI development was significantly associated with increased risk of 2-year mortality (hazard ratio [HR], 2.20 [95% CI, 1.37-3.49]). For patients with AKI, the 2-year mortality rate for complete recovery was 34%; for partial recovery, 43%; and for no recovery, 75%; compared with 20% for patients without AKI (P < .001). In adjusted analysis, complete recovery (HR, 1.87 [95% CI, 1.03-3.23]); partial recovery (HR, 2.65 [95% CI, 1.40-4.71]) and no recovery (HR, 10.95 [95% CI, 2.59-31.49]) after AKI vs no AKI were significantly associated with increased risk of 2-year mortality.Conclusion
The mortality rate increased for all patients with AKI undergoing TAVR. A reverse correlation existed for progressively higher risk of death and the extent of AKI recovery.Item Open Access The comparison of the commonly used surrogates for baseline renal function in acute kidney injury diagnosis and staging.(BMC nephrology, 2016-01) Thongprayoon, Charat; Cheungpasitporn, Wisit; Harrison, Andrew M; Kittanamongkolchai, Wonngarm; Ungprasert, Patompong; Srivali, Narat; Akhoundi, Abbasali; Kashani, Kianoush BBackground
Baseline serum creatinine (SCr) level is frequently not measured in clinical practice. The aim of this study was to investigate the effect of various methods of baseline SCr determination measurement on accuracy of acute kidney injury (AKI) diagnosis in critically ill patients.Methods
This was a retrospective cohort study. All adult intensive care unit (ICU) patients admitted at a tertiary referral hospital from January 1, 2011 through December 31, 2011, with at least one measured SCr value during ICU stay, were included in this study. The baseline SCr was considered either an admission SCr (SCrADM) or an estimated SCr, using MDRD formula, based on an assumed glomerular filtration rate (GFR) of 75 ml/min/1.73 m(2) (SCrGFR-75). Determination of AKI was based on the KDIGO SCr criterion. Propensity score to predict the likelihood of missing SCr was used to generate a simulated cohort of 3566 patients with baseline outpatient SCr, who had similar characteristics with patients whose outpatient SCr was not available.Results
Of 7772 patients, 3504 (45.1 %) did not have baseline outpatient SCr. Among patients without baseline outpatient SCr, AKI was detected in 571 (16.3 %) using the SCrADM and 997 (28.4 %) using SCrGFR-75 (p < .001). Compared with non-AKI patients, patients who met AKI only by SCrADM, but not SCrGFR-75, were significantly associated with 60-day mortality (OR 2.90; 95 % CI 1.66-4.87), whereas patients who met AKI only by SCrGFR-75, but not SCrADM, had a non-significant increase in 60-day mortality risk (OR 1.33; 95 % CI 0.94-1.88). In a simulated cohort of patients with baseline outpatient SCr, SCrGFR-75 yielded a higher sensitivity (77.2 vs. 50.5 %) and lower specificity (87.8 vs. 94.8 %) for the AKI diagnosis in comparison with SCrADM.Conclusions
When baseline outpatient SCr was not available, using SCrGFR-75 as surrogate for baseline SCr was found to be more sensitive but less specific for AKI diagnosis compared with using SCrADM. This resulted in higher incidence of AKI with larger likelihood of false-positive cases.Item Open Access THE VASOPRESSOR USE IN CARDIAC INTENSIVE CARE UNIT: 7 YEARS COHORT STUDY(Critical Care Medicine, 2015-12-01) Srivali, Narat; Thongprayoon, Charat; Cheungpasitporn, WisitLearning Objectives: The use of vasopressor was common in cardiac intensive care unit (CICU). Due to the lack of conclusive evidence in superiority in efficacy among various types of vasopressors, the choice of vasopressor use mainly depends on the physician preference. This study aims to describe the prevalence of vasopressor use and the trend in the use of each vasopressor medication in CICU over the past 7 yr. Methods: This is a descriptive study conducted at a tertiary referral hospital. All cardiac ICU admissions at our institution between January 2007 and December 2013 were included in this study. The use of vasopressor within given CICU day (12.00 am – 11.59 pm) during CICU stay was reviewed. Vasopressors were defined as the continuous intravenous administration of norepinephrine, epinephrine, dopamine, phenylephrine, or vasopressin regardless of duration and dosage. The use of each vasopressor was reported as the vasopressor utilization index (VUI), using the following formula Vasopressor utilization index (VUI) = (The total number of ICU days on a given vasopressor)/(The total number of ICU days on any vasopresor). Results: Out of 5,659 ICU days with vasopressor use, dopamine was used for 4,320 (76%), norepinephrine for 958 (17%), vasopressin for 661 (12%), epinephrine for 534 (9%), and phenylephrine for 471 (8%). From 2007 through 2013, there was a slight decreasing trend in the use of epinephrine (VUIepinephrine was 0.13 in 2007 and 0.06 in 2013), phenylephrine (VUIphenylephrine was 0.14 in 2008 and 0.05 in 2013), and vasopressin (VUIvasopressin was 0.19 in 2007 and 0.08 in 2013). Norepinephrine and dopamine trends did not change In the cardiac care unit, use of low-dose dopamine is still common (VUIlow-dose dopamine was 0.46) without any decreasing trend in its utilization. Conclusions: Dopamine was the most commonly used vasopressor from 2007 through 2013 in cardiac ICU. Despite several recent trials and guidelines showing the adverse effects of dopamine use, it is still used frequently in the cardiac care unit.Item Open Access Transapical versus transfemoral approach and risk of acute kidney injury following transcatheter aortic valve replacement: a propensity-adjusted analysis.(Renal failure, 2017-11) Thongprayoon, Charat; Cheungpasitporn, Wisit; Srivali, Narat; Harrison, Andrew M; Kittanamongkolchai, Wonngarm; Greason, Kevin L; Kashani, Kianoush BBackground
The aim of this study was to compare the incidence of post-procedural acute kidney injury (AKI) and other renal outcomes in patients undergoing transapical (TA) and transfemoral (TF) approaches for transcatheter aortic valve replacement (TAVR).Methods
All consecutive adult patients undergoing TAVR for aortic stenosis from 1 January 2008 to 30 June 2014 at a tertiary referral hospital were included. AKI was defined based on Kidney Disease Improving Global Outcomes (KDIGO) criteria. Logistic regression adjustment, propensity score stratification, and propensity matching were performed to assess the independent association between procedural approach and AKI.Results
Of 366 included patients, 171 (47%) underwent TAVR via a TA approach. AKI occurrence in this group was significantly higher compared to the TF group (38% vs. 18%, p < .01). The TA approach remained significantly associated with increased risk of AKI after logistic regression (OR 3.20; CI 1.68-4.36) and propensity score adjustment: OR 2.83 (CI 1.66-4.80) for stratification and 3.82 (CI 2.04-7.44) for matching. Nonetheless, there was no statistically significant difference among the TA and TF groups with respect to major adverse kidney events (MAKE) or estimated glomerular filtration rate (eGFR) at six months post-procedure.Conclusion
In a cohort of patients undergoing TAVR for aortic stenosis, a TA approach significantly increases the AKI risk compared with a TF approach. However, the TAVR approach did not affect severe renal outcomes or long-term renal function.Item Open Access Trends In The Use Of Vasopressors In Cardiac Surgery Intensive Care Unit(American Journal of Respiratory and Critical Care Medicine) Srivali, Narat; Thongprayoon, Charat; Cheungpasitporn, Wisit; Kashani, Kianoush BItem Open Access Trends of vasopressor using in medical intensive care unit: a 7-year cohort study(Intensive Care Medicine Experimental, 2015-10-01) Srivali, Narat; Thongprayoon, Charat; Cheungpasitporn, Wisit; Kashani, KIntroduction The use of vasopressor was common in medical intensive care unit (MICU). Due to the lack of conclusive evidence in superiority in efficacy among various types of vasopressors, the choice of vasopressor use mainly depends on the physician preference. Objectives This study aims to describe the prevalence of vasopressor use and the trend in the use of each vasopressor medication in MICU over the past 7 years. Methods This is a descriptive study conducted at a tertiary referral hospital. All MICU admissions at our institution between January 2007 and December 2013 were included in this study. The use of vasopressor within given ICU day (12.00 am - 11.59 pm) during ICU stay was reviewed. Vasopressors were defined as the continuous intravenous administration of norepinephrine, epinephrine, dopamine, phenylephrine, or vasopressin regardless of duration and dosage. The use of each vasopressor was reported as the vasopressor utilization index (VUI), using the following formula Vasopressor utilization index (VUI) = The total number of ICU days on a given vasopressor/The total number of ICU days on any vasopressor. Results A total of 16,863 unique patients had 17,164 MICU admissions in the course of study, (55,391patient*ICU day).Out of 7,739 ICU days with vasopressor use, norepinephrine was used for 6,414 (83%), vasopressin for 1,960 (25%), phenylephrine for 772 (10%), dopamine for 623 (8%), and epinephrine for 323 (4%). From 2007 through 2013, there was an increasing trend in the use of norepinephrine (VUInorepinephrine was 0.69 in 2007 and 0.91 in 2013) and an slight increasing trend in the use of epinephrine (VUIepinephrine was 0.01 in 2007 and 0.06 in 2013). There was a decreasing trend in the use of dopamine (VUIdopamine was 0.15 in 2007 and 0.03 in 2013), vasopressin (VUIvasopressin was 0.42 in 2007 and 0.22 in 2013), and a slight downward trend in the use of phenylephrine. Conclusions Norepinephrine is the most commonly used vasopressor in MICU. The use of norepinephrine and epinephrine are in upward trajectory.