Browsing by Author "Enyedi, Laura B"

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    Assessment of Macular Microvasculature in Healthy Eyes of Infants and Children Using OCT Angiography.
    (Ophthalmology, 2019-12) Hsu, S Tammy; Ngo, Hoan T; Stinnett, Sandra S; Cheung, Nathan L; House, Robert J; Kelly, Michael P; Chen, Xi; Enyedi, Laura B; Prakalapakorn, S Grace; Materin, Miguel A; El-Dairi, Mays A; Jaffe, Glenn J; Freedman, Sharon F; Toth, Cynthia A; Vajzovic, Lejla
    PURPOSE:To assess macular vasculature in healthy infants and children using OCT angiography (OCTA). DESIGN:Prospective cross-sectional study. PARTICIPANTS:One hundred thirty-five normal maculae of 89 healthy infants and children (mean age, 8.5±5.3 years; range, 9 weeks-17 years) treated at the Duke University Eye Center. METHODS:We imaged 135 maculae of 89 pediatric patients using the standard Spectralis tabletop and investigational Spectralis with Flex module devices, both equipped with investigational OCTA software (Heidelberg Engineering, Heidelberg, Germany). OCT angiography images of the superficial vascular complex (SVC) and deep vascular complex (DVC) were analyzed for foveal avascular zone (FAZ) area and superficial and deep vessel density. We assessed effects of age, gender, race, axial length (AL), and central subfield thickness on FAZ and vessel density. Patients with both eyes imaged were assessed for agreement between the FAZ and vessel densities of the left and right eyes. MAIN OUTCOME MEASURES:The FAZ area, as well as vessel area density (VAD) and vessel length density (VLD) in the SVC and DVC. RESULTS:The FAZ varied significantly with race; white patients showed a significantly smaller FAZ than black patients (mean difference, 0.11 mm2; P = 0.004). The FAZ did not vary with age, gender, or AL (P > 0.05). In the SVC, VAD and VLD varied significantly with age (P < 0.001) and AL (R2 = 0.46; P < 0.001) but not gender (P > 0.05). The SVC VLD was significantly different between races and ethnicities (P = 0.037), but VAD was not (P < 0.05). In the DVC, VAD and VLD also varied significantly with age (P < 0.001) and AL (R2 = 0.46; P < 0.001) but not gender or race (P > 0.05). There was excellent agreement between the right and left eyes for FAZ (intraclass correlation [ICC], 0.97), SVC VLD (ICC, 1.00), and DVC VLD (ICC, 1.00). CONCLUSIONS:Quantitative studies of pediatric perifoveal vasculature should consider age, race, and AL. In eyes with unilateral disease, the perifoveal vasculature in the unaffected eye may be used as a control comparison because there is excellent agreement between eyes.
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    ItemOpen Access
    Refractive Error Change and Overminus Lens Therapy for Childhood Intermittent Exotropia
    (JAMA Ophthalmology) Alexander, Monsey L; Allen, Megan; Alluri, Sreevardhan; Amster, Deborah M; Anderson, Heather A; Argoubi, Afifa; Astle, William F; Austin, Darrell S; Bailey, Maragaret K; Baker, John D; Beaulieu, Wesley T; Beck, Roy W; Berns, Fabiana; Bhatt, Amit R; Birch, Eileen E; Bitner, Derek P; Bland, Tracy A; Bodack, Marie I; Boente, Charline S; Bohra, Lisa; Bond, Lezlie L; Bothun, Erick D; Boyle, Nicole M; Brafford, Randy C; Castle, Kelly M; Chamberlain, Carolyn; Cheung, Nathan L; Christiansen, Stephen P; Christoff, Alex; Chung, Ida; Cioffi, Katherine R; Clausius, Deborah A; Cobb, Patricia; Collins, Mary Louise Z; Colon, Beth J; Conley, Julie A; Conner, Courtney L; Connolly, Katie S; Cooper, Karen; Crossnoe, Connie J; Crouch, Eric R; Cupit, Shawn L; Curtis, Linda T; Cutrer, Beth M; Davis, Barry; de Alba Campomanes, Alejandra G; De Leon, Erika A; Dean, Trevano W; Diener-West, Marie I; Dillon, Angela C; Dinani, Zainab; Donahue, Quayleen; Donahue, Sean P; Droste, Patrick J; Ecerova, Zuzana; Eltzroth, Jillian M; Esposito, Christina A; Evans, Patricia L; Everett, Donald F; Fang, Caroline C; Feis, Alicia E; Fergus, Lisa M; Fimbel, Brooke P; Fishman, Deborah R; Flanagan, Maureen A; Forde, Roberta A; Fouzdar Jain, Samisksha; Franklin, John Mark; Frazier, Marcela; Gafford, Jennifer B; Geddie, Brooke E; Gertsch, Kevin R; Gianfermi, Elena; Gray, Michael E; Grigorian, Adriana P; Gunton, Kammi B; Hahn, Alexis C; Hahn-Parrott, Laurie; Haider, Kathryn M; Haley, Wendy Jean; Hatch, Stanley W; Hatt, Sarah R; Henderson, Robert J; Heyman, Catherine L; Higgins, Rosemary D; Hilbrands, Jan; Hoepner, James E; Holleschau, Ann M; Holtorf, Hannah L; Hoover, Darren L; Hopkins, Kristine B; Huang, Kristine; Hutchinson, Amy K; James, Yvonne R; Jastrzemsbki, Benjamin G; Jenewein, Erin C; Jensen, Allison A; Jhajj, Jasleen K; Jones, Sarah K; Jordan, Catherine O; Kaplon, Joseph D; Khan, Shabana; Klaehn, Lindsay D; Kong, Lingkun; Koontz, Emily R; Koutnik, Cassandra A; Kramer, Andrea M; Kraus, Courtney L; Krueger, Samantha L; Kulp, Marjean T; Kurup, Sudhi P; LaMattina, Kara C; Lambert, Jennifer E; Lambert, Scott R; Law, Cristina L; Lazar, Elizabeth L; Leach, Shelby; Lee, Katherine A; Leske, David A; Li, Zhuokai; Lim, Maria E; Liu, Xiaonong; Lorenzana, Ingryd; Loud, Rachel N; Lyon, Don W; Lyons, Alex F; Manuchian, Sonia; Marozas, Lauren; Marsh, Justin D; Martinson, Stacy R; May, Laura M; McCoy Vrablec, Laura; McMurtrey, J Ryan; Meil, Gail C; Melia, B Michele; Merrill, Kim S; Mets-Halgrimson, Rebecca B; Meyers, Sara R; Miller, Aaron M; Miller, Caiytlin C; Mohney, Brian G; Montejo, Jenifer; Morgan, Linda; Morrison, Kelsie B; Morrison, Ann M; Morrison, David G; Myung, Jenny; Nash, David L; Nylin, Elyse; Oechslin, Tamara S; Olvera, Maria N; Ortiz, Gillaine; Oseguera, Teresa; Pang, Yi; Parker, Sue M; Patel, Reena A; Paysse, Evelyn A; Peragallo, Jason H; Perzyk, Susan N; Peters, Robert J; Phillips, Paul H; Plaumann, Maureen D; Plum, Larry W; Poff, Stephen W; Pollack, Karen E; Qayum, Jennifer N; Quebbemann, Micaela N; Raghuram, Aparna; Rahmani, Bahram; Ralay Ranaivo, Hantamalala; Repka, Michael X; Retnasothie, Dashaini V; Roberts, Tawna L; Robinson, Julianne L; Roe, Matthew K; Romany, Gihan; Rutner, Daniella; Sala, Allyson; Sanders, Emi N; Saunders, Richard A; Sayani, Amar; Scheiman, Mitchell M; Schulman-Ellis, Erica L; Shah, Birva K; Shah, Veeral S; Shelton, Erica R; Siatkowski, R Michael; Slinger, Kristin E; Smith, Rachel M; Solis, Casandra S; Stec, Magdalena; Stevens, Nancy E; Stevens, Julia L; Stewart, Miqua L; Strul, Sasha; Stutz, Kathleen M; Suh, Donny W; Summers, Allison I; Superstein, Roseanne; Sutherland, Desirae R; Tamkins, Susanna M; Taub, Marc B; Thibeault, Maryse; Titelbaum, Jenna R; Tolbert, Tiffany T; Toole, Andrew J; Toro, David O; Tung, Irene T; Twardowski, Christina M; Tychsen, Lawrence; Tzanetakos, Vivian; Varney, Kelly D; Ventura, Gaylord G; Verderber, Lisa C; Walker, Kimberly R; Wall, Palak B; Wallace, David K; Wang, Jingyun; Weise, Katherine K; Wernimont, Suzanne M; Willen, Christi M; Wolinski, Elisabeth T; Woodard, Victoria C; Wright, Martha M; Yamada, Tomohiko; Yen, Kimberly G; Yonkers, Amanda M; Freedman, Sharon F; Christian, Melanie L; Crouch, Earl R; Enyedi, Laura B; Good, William V; Jackson, Jorie L; London, Richard; Manh, Vivian M; Manny, Ruth E; Morrell, Beth A; Petersen, David B; Pineles, Stacy L; Rogers, David L; Ruark, Scott T; Schweinler, Bonita R; Silver, Jayne L; Chen, Angela M; Erzurum, S Ayse; Chandler, Danielle L; Hercinovic, Amra; Wu, Rui; Vricella, Marilyn; Waters, Amy L; Ticho, Benjamin H; Erickson, John W; Han, Silvia; McDowell, Paula S; Li, Zhuokai; Kraker, Raymond T; Holmes, Jonathan M; Cotter, Susan A
    ImportanceIncreased myopic shift was found to be associated with 1 year of overminus spectacle treatment for children with intermittent exotropia (IXT). Persistence of myopic shift after discontinuing overminus spectacles is unknown.ObjectiveTo compare refractive error change over 3 years in children with IXT originally treated with overminus vs nonoverminus spectacles.Design, Setting, and ParticipantsThis study was an 18-month extension of the Trial of Overminus Spectacle Therapy for Intermittent Exotropia cohort, which previously randomized children aged 3 to 10 years with IXT and baseline spherical equivalent refractive error (SER) between −6.00 diopters (D) and 1.00 D to overminus spectacles (−2.50 D for 12 months, −1.25 D for 3 months, and nonoverminus for 3 months) or nonoverminus spectacles. Children were recruited from 56 sites from July 2010 to February 2022. Data were analyzed from February 2022 to January 2024.InterventionsAfter trial completion at 18 months, participants were followed up at 24 and 36 months. Treatment was at investigator discretion from 18 to 36 months.Main Outcomes and MeasuresChange in SER (cycloplegic retinoscopy) from baseline to 36 months.ResultsOf 386 children in the Trial of Overminus Spectacle Therapy for Intermittent Exotropia, 223 (57.8%) consented to 18 months of additional follow-up, including 124 of 196 (63.3%) in the overminus treatment group and 99 of 190 (52.1%) in the nonoverminus treatment group. Of 205 children who completed 36-month follow-up, 116 (56.6%) were female, and the mean (SD) age at randomization was 6.2 (2.1) years. Mean (SD) SER change from baseline to 36 months was greater in the overminus group (−0.74 [1.00] D) compared with the nonoverminus group (−0.44 [0.85] D; adjusted difference, −0.36 D; 95% CI, −0.59 to −0.12; P = .003), with 30 of 112 (26.8%) in the overminus group having more than 1 D of myopic shift compared with 14 of 91 (15%) in the nonoverminus group (risk ratio, 1.8; 95% CI, 1.0-3.0). From 12 to 36 months, mean (SD) myopic shift was −0.34 (0.67) D and −0.36 (0.66) D in the overminus and nonoverminus groups, respectively (adjusted difference, −0.001 D; 95% CI, −0.18 to 0.18; P = .99).Conclusions and RelevanceThe greater myopic shift observed after 1 year of −2.50-D overminus lens treatment remained at 3 years. Both groups had similar myopic shift during the 2-year period after treatment weaning and cessation. The risk of myopic shift should be discussed with parents when considering overminus lens treatment.Trial RegistrationClinicalTrials.gov Identifier: NCT02807350