Browsing by Author "Goldberg, JS"
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Item Open Access Atherosclerosis: Viewing the problem from a different perspective including possible treatment options(Lipid Insights, 2011-12-01) Goldberg, JSThis paper proposes that atherosclerosis is initiated by a signaling event that deposits calcium hydroxyapatite (Ca-HAP). This event is preceded by a loss of mechanical structure in the arterial wall. After Ca-HAP has been deposited, it is unlikely that it will be reabsorbed because the solubility product constant (K sp) is very small, and the large stores of Ca +2 and PO 4-3 in the bones oppose any attempts to dissolve Ca-HAP by decreasing the common ions. The hydroxide ion (OH -) of Ca-HAP can be displaced in nature by fluoride (F -) and carbonate (CO 3-2) ions, and it is proposed that anions associated with cholesterol ester hydrolysis and, in very small quantities, the enolate of 7-ketocholesterol could also displace the OH -of Ca-HAP, forming an ionic bond. The free energy of hydration of Ca-HAP at 310 K is most likely negative, and the ionic radii of the anions associated with the hydrolysis of cholesterol ester are compatible with the substitution. Furthermore, examination of the pathology of atherosclerotic lesions by Raman and NMR spectroscopy and confocal microscopy supports deposition of Ca-HAP associated with cholesterol. Investigating the affinity of intermediates of cholesterol hydrolysis for Ca-HAP compared to lipoproteins such as HDL, LDL, and VLDL using isothermic titration calorimetry could add proof of this concept and may lead to the development of a new class of medications targeted at the deposition of cholesterol within Ca-HAP. Treatment of acute ischemic events as a consequence of atherosclerosis with denitrogenation and oxygenation is discussed. © the author(s), publisher and licensee Libertas Academica Ltd.Item Open Access CITRATE DISSOLUTION OF BETA-2-MICROGLOBULIN AND AMYLOID BETA PEPTIDE (1-40) AGGREGATES(2018-11-22) Goldberg, JSItem Open Access CITRATE RESORPTION OF BONE AS A TREATMENT FOR SPINAL STENOSIS(2017-04-11) Goldberg, JSItem Open Access Item Open Access COHERENT ELECTROMAGNETIC WAVES AID RECONCILIATION(2016-10-20) Goldberg, JSItem Open Access Corrigendum for "Stereocomplexes Formed From Select Oligomers of Polymer D-lactic Acid (PDLA) and L-lactate May Inhibit Growth of Cancer Cells and Help Diagnose Aggressive Cancers-Applications of the Warburg Effect"(Perspect Medicin Chem, 2014) Goldberg, JS[This corrects the article on p. 1 in vol. 5, PMID: 21487535.].Item Open Access DECALCIFICATION OF PASTURE GRASS FOR FOOD AND FUEL(2016-09-22) Goldberg, JSItem Open Access Global traumatic stress: Hypothetical events and possible solutions(Traumatology, 2009-06-01) Goldberg, JSThe purpose of this article is to heighten awareness of the potential psychiatric consequences of a global traumatic event such as widespread use of weapons of mass destruction, encounter with an extraterrestrial life form, Earth's collision with an asteroid, paralysis of telecommunication or power systems, or pandemics. Because such events have never occurred, the traumatic affects on the human mind can only be postulated. There is sparse if any literature that addresses this problem. Many of the assumptions of what may happen and possible solutions are within the speculative imagination of the author. It is important that the traumatic stresses of a global event at least be recognized in the medical literature rather than be exclusively the domain of science fiction or cinematography. © 2009 The Author(s).Item Open Access GLYCATION OF L-LYSINE TO LOWER BLOOD GLUCOSE AND TREAT COMPLICATIONS OF DIABETES(2015-08-19) Goldberg, JSItem Open Access LOCAL APPLICATION OF D-LACTIC ACID DIMER IS SELECTIVELY CYTOTOXIC WHEN APPLIED TO CANCER CELLS(2018-03-29) Goldberg, JS; Weinberg, Joe BriceThe experimental data supports the cytotoxic mechanism of D-lactic acid dimer via the Warburg effect.Item Open Access Item Open Access METHOD TO DECREASE BRAIN INJURY FOLLOWING CEREBRAL ISCHEMIA(2016-08-11) Goldberg, JSItem Open Access METHOD TO MAINTAIN PEACE THORUGH ELECTROMAGNETIC ENERGY TARGETED TO THE BRAIN(2016-12-29) Goldberg, JSItem Open Access METHOD TO OPTIMIZE ELECTRODE PLACEMENT FOR CRANIAL ELECTRICAL STIMULATION(2016-12-05) Goldberg, JSItem Open Access NOVEL SYNTHESIS OF POTENTIAL ESTER PRODRUGS(2017-06-15) Goldberg, JSItem Open Access OPIOID PEPTIDE ESTERS AND METHODS OF USE(2015-08-22) Goldberg, JSItem Open Access Item Open Access SYNTHESIS AND IN VITRO ACTIVITY OF D-LACTIC ACID OLIGOMERS(2018-09-27) Goldberg, JS; Gooden, DavidThis invention describes the synthesis and pharmacologic activity of n = 2 , n = 3 , n = 4 , n = 5 , and n = 6 D - lactic acid oligomers . D - lactic acid dimer has pharmacologic activity and sequesters L - lactate , and the other D - lactic acid oligom ers have no activity in vitro , but may have pharmacologic activity in vivo as prodrugs of D - lactic acid dimer .Item Open Access THERMODYNAMIC MODEL OF A NERVOUS SYSTEM(2015-12-31) Goldberg, JSItem Open Access TRANSCRANIAL MAGNETIC LESIONING OF THE NERVOUS SYSTEM FOR RELIEF OF INTRACTABLE PAIN(2017-07-06) Goldberg, JS