Browsing by Author "Goldstein, DB"
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Item Open Access Contributions of Mamu-A*01 status and TRIM5 allele expression, but not CCL3L copy number variation, to the control of SIVmac251 replication in Indian-origin rhesus monkeys(2010) Lim, SY; Chan, T; Gelman, RS; Whitney, JB; O'Brien, KL; Barouch, DH; Goldstein, DB; Haynes, BF; Letvin, NLItem Restricted Genome-wide scan of copy number variation in late-onset Alzheimer's disease.(J Alzheimers Dis, 2010) Heinzen, EL; Need, AC; Hayden, KM; Chiba Falek, O; Roses, AD; Strittmatter, WJ; Burke, JR; Hulette, CM; Welsh Bohmer, KA; Goldstein, DBAlzheimer's disease is a complex and progressive neurodegenerative disease leading to loss of memory, cognitive impairment, and ultimately death. To date, six large-scale genome-wide association studies have been conducted to identify SNPs that influence disease predisposition. These studies have confirmed the well-known APOE epsilon4 risk allele, identified a novel variant that influences disease risk within the APOE epsilon4 population, found a SNP that modifies the age of disease onset, as well as reported the first sex-linked susceptibility variant. Here we report a genome-wide scan of Alzheimer's disease in a set of 331 cases and 368 controls, extending analyses for the first time to include assessments of copy number variation. In this analysis, no new SNPs show genome-wide significance. We also screened for effects of copy number variation, and while nothing was significant, a duplication in CHRNA7 appears interesting enough to warrant further investigation.