Browsing by Author "Guo, Yuan"
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Item Embargo Customer Choice Models in Emerging Retail Markets(2023) Guo, YuanIn this dissertaion we discuss customer choice and company decisions in three emerging retail settings. We first consider subscription box services in which a provider selects the assortment of products to include in the box by taking into account the customer's preferences. Customers interested in purchasing a product choose between engaging in searching physical stores or subscribing to a box delivery service. We study the subscription box company's problem of selecting the optimal contents of the box to maximize expected revenue (by driving demand from customers). We model the interaction between customer search and subscription by applying a cross-nested logit framework that correlates the contents in the box with the products available at the stores. We find that if a preview of the box is available, for customers with intermediate values of the search cost, it may be optimal to include a so-called utility loss leader, i.e., a product with relatively low valuation, to entice customers to subscribe to the box delivery service and therefore increase the likelihood of a sale. Next, we study companies' problem selling in social media, where brands attach product tags directly in their posts and users can complete their purchase by clicking on these tags. We propose a novel choice model that captures the users' impulsive behavior and limited attention span while browsing products in social media platforms. We consider a seller's product display problem on a product page and examine different strategies to sell through social media. We find that, depending on the product preferences and the users' pattern of attention decay, the optimal display set can have different structure. Finally, we discuss the fashion retailer's production problem selling in a market where a secondhand platform collects old clothes from customers and resells them. We construct a customer decision model that captures their consumption of new and/or used products under transitioning fashion trends over time. We find that if the platform operates independently and the hassle cost related to buying and selling used goods is high, the retailer's optimal production decision will not be affected by the existence of the secondhand market.
Item Open Access Functional polymorphisms of CHRNA3 predict risks of chronic obstructive pulmonary disease and lung cancer in Chinese.(PloS one, 2012-01) Yang, Lei; Qiu, Fuman; Lu, Xiaoxiao; Huang, Dongsheng; Ma, Guanpei; Guo, Yuan; Hu, Min; Zhou, Yumin; Pan, Mingan; Tan, Yigang; Zhong, Haibo; Ji, Weidong; Wei, Qingyi; Ran, Pixin; Zhong, Nanshan; Zhou, Yifeng; Lu, JiachunRecently, several genome-wide association studies (GWAS) have identified many susceptible single nucleotide polymorphisms (SNPs) for chronic obstructive pulmonary disease (COPD) and lung cancer which are two closely related diseases. Among those SNPs, some of them are shared by both the diseases, reflecting there is possible genetic similarity between the diseases. Here we tested the hypothesis that whether those shared SNPs are common predictor for risks or prognosis of COPD and lung cancer. Two SNPs (rs6495309 and rs1051730) located in nicotinic acetylcholine receptor alpha 3 (CHRNA3) gene were genotyped in 1511 patients with COPD, 1559 lung cancer cases and 1677 controls in southern and eastern Chinese populations. We found that the rs6495309CC and rs6495309CT/CC variant genotypes were associated with increased risks of COPD (OR = 1.32, 95% C.I. = 1.14-1.54) and lung cancer (OR = 1.57; 95% CI = 1.31-1.87), respectively. The rs6495309CC genotype contributed to more rapid decline of annual Forced expiratory volume in one second (FEV1) in both COPD cases and controls (P<0.05), and it was associated with advanced stages of COPD (P = 0.033); the rs6495309CT/CC genotypes conferred a poor survival for lung cancer (HR = 1.41, 95%CI = 1.13-1.75). The luciferase assays further showed that nicotine and other tobacco chemicals had diverse effects on the luciferase activity of the rs6495309C or T alleles. However, none of these effects were found for another SNP, rs1051730G>A. The data show a statistical association and suggest biological plausibility that the rs6495309T>C polymorphism contributed to increased risks and poor prognosis of both COPD and lung cancer.Item Open Access Techniques for Quantitation of Left Ventricular Volume in Ultrasound Using 4DViz(2012) Guo, YuanIn the United States, heart failure is a leading cause of hospitalization. The medical industry places great emphasis on diagnosing heart disease through cardiac metrics like ejection fraction. Left ventricular ejection fraction is a commonly used diagnostic indicator for heart efficiency and is measured with echocardiography through different volume calculation techniques. However, ejection fraction results can drastically vary from one examiner to another. Generally cardiologists still give ejection fraction measurements a plus or minus 10 percent error range.
A program developed at Duke called 4DViz is robust enough for users to process 3D ultrasound data. 4DViz allows examiners to determine heart chamber volumes by constructing a surface model over an imaged heart chamber with many mouse click inputs. Through 4DViz programming, a viable approach for calculating ejection fraction is attempted in this thesis. Using feature tracking, surface drawing, and voxel filling, the new approach aims to reduce examiner input and improve ejection fraction consistency. Water filled balloons were used to calibrate the algorithm's parameters. In testing, several volunteers were asked to use the 4DViz. Their results are compared to volume measurements where user input was standard. The results show promise and may remove some of the inconsistency behind ejection fraction measurements.