Browsing by Author "Holt, Graham Thomas"
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Item Open Access Ensemble-based Computational Protein Design: Novel Algorithms and Applications to Energy Landscape Approximation, Antibiotic Resistance, and Antibody Design(2022) Holt, Graham ThomasProteins are incredibly varied in their biological function, and are therefore attractive targets for scientists and engineers to design new and improved functions. These functions are defined by a protein structure, which can be viewed as a probability distribution over a large conformation space. Many successful protein design methods construct and evaluate models of protein structure and physics in silico to design proteins. We apply the concept of protein structure as a probability distribution to design new protein design algorithms, study mechanisms of protein binding and antibiotic resistance, and design improved broadly-neutralizing antibodies This research highlights the utility of the distribution view of protein structure, and suggests future research in this direction.