Browsing by Author "Hu, Min"

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    Functional polymorphisms of CHRNA3 predict risks of chronic obstructive pulmonary disease and lung cancer in Chinese.
    (PloS one, 2012-01) Yang, Lei; Qiu, Fuman; Lu, Xiaoxiao; Huang, Dongsheng; Ma, Guanpei; Guo, Yuan; Hu, Min; Zhou, Yumin; Pan, Mingan; Tan, Yigang; Zhong, Haibo; Ji, Weidong; Wei, Qingyi; Ran, Pixin; Zhong, Nanshan; Zhou, Yifeng; Lu, Jiachun
    Recently, several genome-wide association studies (GWAS) have identified many susceptible single nucleotide polymorphisms (SNPs) for chronic obstructive pulmonary disease (COPD) and lung cancer which are two closely related diseases. Among those SNPs, some of them are shared by both the diseases, reflecting there is possible genetic similarity between the diseases. Here we tested the hypothesis that whether those shared SNPs are common predictor for risks or prognosis of COPD and lung cancer. Two SNPs (rs6495309 and rs1051730) located in nicotinic acetylcholine receptor alpha 3 (CHRNA3) gene were genotyped in 1511 patients with COPD, 1559 lung cancer cases and 1677 controls in southern and eastern Chinese populations. We found that the rs6495309CC and rs6495309CT/CC variant genotypes were associated with increased risks of COPD (OR = 1.32, 95% C.I. = 1.14-1.54) and lung cancer (OR = 1.57; 95% CI = 1.31-1.87), respectively. The rs6495309CC genotype contributed to more rapid decline of annual Forced expiratory volume in one second (FEV1) in both COPD cases and controls (P<0.05), and it was associated with advanced stages of COPD (P = 0.033); the rs6495309CT/CC genotypes conferred a poor survival for lung cancer (HR = 1.41, 95%CI = 1.13-1.75). The luciferase assays further showed that nicotine and other tobacco chemicals had diverse effects on the luciferase activity of the rs6495309C or T alleles. However, none of these effects were found for another SNP, rs1051730G>A. The data show a statistical association and suggest biological plausibility that the rs6495309T>C polymorphism contributed to increased risks and poor prognosis of both COPD and lung cancer.
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    ItemOpen Access
    Green Is Not Enough: A Management Framework for Urban Biodiversity Friendly Parks
    (2023-05-05) Hu, Min
    The potential of cities to conserve biodiversity is increasingly gaining more recognition and cities mainly contribute to biodiversity through planning and managing urban green spaces (UGS), for example, urban parks. Research finds that the ability of UGS to support biodiversity depends on several factors, and management activities are one of them. Urban parks are important urban infrastructures and are under a high level of management. Proper management after planning and construction is significant for meeting human needs as well as providing suitable habitats for wildlife. Therefore, understanding how urban parks are managed and operated is critical for urban biodiversity enhancement but accepts insufficient attention in China. This research focuses on the management stage of Chinese urban parks and tries to answer: how could urban parks effectively enhance biodiversity by changing management practices? Through identifying the improvement spaces and exploring the root causes including government failure and market failure, I propose a policy suggestion of a certificate of urban biodiversity friendly parks and generate a management framework as a tool for urban parks to make changes.