Browsing by Author "Hu, S"

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    Bispecific Antibody Therapy for Effective Cardiac Repair through Redirection of Endogenous Stem Cells
    (Advanced Therapeutics, 2019-10-01) Huang, K; Li, Z; Su, T; Shen, D; Hu, S; Cheng, K
    Bone marrow stem cells (BMSCs) are a promising strategy for cardiac regenerative therapy for myocardial infarction (MI). However, cell transplantation has to overcome a number of hurdles, such as cell quality control, clinical practicality, low cell retention/engraftment, and immune reactions when allogeneic cells are used. Bispecific antibodies (BsAbs) have been developed as potential agents in cancer immunotherapy but their application is sparse in cardiovascular diseases. In the present study, BsAbs are designed by chemical cycloaddition of F(ab′)2 fragments from monoclonal anti-CD34 and anti- cardiac myosin heavy chain (CMHC) antibodies, which specifically targets circulating CD34-positive cells and injured cardiomyocytes simultaneously. It is hypothesized that intravenous administration of stem cell re-directing (SCRD) BsAbs (anti-CD34-F(ab′)2–anti-CMHC-F(ab′)2) can home endogenous BMSCs to the injured heart for cardiac repair. The in vivo studies in a mouse model with heart ischemia/reperfusion (I/R) injury demonstrate the safety and therapeutic potency of SCRD BsAb, which supports cardiac recovery by reducing scarring, promoting angiomyogenesis, and boosting cardiac function.
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    The Causes and Consequences of Refugee Flows: A Contemporary Reanalysis
    (American Political Science Review, 2025-02-01) Shaver, A; Krick, B; Blancaflor, J; Liu, X; Samara, G; Ku, SY; Hu, S; Angelo, J; Carreon, M; Lim, T; Raps, R; Velasquez, A; De Melo, S; Zuo, Z
    The world faces a forced displacement crisis. Tens of millions of individuals have been forced across international boundaries worldwide. Therefore, the causes and consequences of refugee flows are the subjects of significant social science inquiry. Unfortunately, the historical lack of reliable data on actual refugee flows, country-specific data reporting timelines, and more general pre-2000 data quality issues have significantly limited empirical inferences on these topics. We replicate 28 articles on these topics using data newly released after a multiyear collaboration with the United Nations on annual dyadic flows. We observe major inconsistencies between the newly released flow numbers and the stock-based flow estimates upon which decades of research are based; we also find widespread inappropriate treatment of missing historical values. When we replicate the existing literature using the newly introduced flow data, correcting the treatment of missing historical values, and temporally extending/restricting the study periods, we produce significantly different results.