Browsing by Author "Huang, Chih-Hsien"
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Item Open Access High-speed label-free functional photoacoustic microscopy of mouse brain in action.(Nat Methods, 2015-05) Yao, Junjie; Wang, Lidai; Yang, Joon-Mo; Maslov, Konstantin I; Wong, Terence TW; Li, Lei; Huang, Chih-Hsien; Zou, Jun; Wang, Lihong VWe present fast functional photoacoustic microscopy (PAM) for three-dimensional high-resolution, high-speed imaging of the mouse brain, complementary to other imaging modalities. We implemented a single-wavelength pulse-width-based method with a one-dimensional imaging rate of 100 kHz to image blood oxygenation with capillary-level resolution. We applied PAM to image the vascular morphology, blood oxygenation, blood flow and oxygen metabolism in both resting and stimulated states in the mouse brain.