Browsing by Author "Huang, Xin"

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Open Access
Financial Market Volatility and Jumps
(2007-05-07T19:07:04Z) Huang, Xin
This dissertation consists of three related chapters that study financial market volatility, jumps and the economic factors behind them. Each of the chapters analyzes a different aspect of this problem. The first chapter examines tests for jumps based on recent asymptotic results. Monte Carlo evidence suggests that the daily ratio z-statistic has appropriate size, good power, and good jump detection capabilities revealed by the confusion matrix comprised of jump classification probabilities. Theoretical and Monte Carlo analysis indicate that microstructure noise biases the tests against detecting jumps, and that a simple lagging strategy corrects the bias. Empirical work documents evidence for jumps that account for seven percent of stock market price variance. Building on realized variance and bi-power variation measures constructed from high-frequency financial prices, the second chapter proposes a simple reduced form framework for modelling and forecasting daily return volatility. The chapter first decomposes the total daily return variance into three components, and proposes different models for the different variance components: an approximate long-memory HAR-GARCH model for the daytime continuous variance, an ACH model for the jump occurrence hazard rate, a log-linear structure for the conditional jump size, and an augmented GARCH model for the overnight variance. Then the chapter combines the different models to generate an overall forecasting framework, which improves the volatility forecasts for the daily, weekly and monthly horizons. The third chapter studies the economic factors that generate financial market volatility and jumps. It extends the recent literature by separating market responses into continuous variance and discontinuous jumps, and differentiating the market’s disagreement and uncertainty. The chapter finds that there are more large jumps on news days than on no-news days, with the fixed-income market being more responsive than the equity market, and non-farm payroll employment being the most influential news. Surprises in forecasts impact volatility and jumps in the fixed-income market more than the equity market, while disagreement and uncertainty influence both markets with different effects on volatility and jumps. JEL classification: C1, C2, C5, C51, C52, F3, F4, G1, G14
Open Access
Peptide interfacial biomaterials improve endothelial cell adhesion and spreading on synthetic polyglycolic acid materials.
(Ann Biomed Eng, 2010-06) Huang, Xin; Zauscher, Stefan; Klitzman, Bruce; Truskey, George A; Reichert, William M; Kenan, Daniel J; Grinstaff, Mark W
Resorbable scaffolds such as polyglycolic acid (PGA) are employed in a number of clinical and tissue engineering applications owing to their desirable property of allowing remodeling to form native tissue over time. However, native PGA does not promote endothelial cell adhesion. Here we describe a novel treatment with hetero-bifunctional peptide linkers, termed "interfacial biomaterials" (IFBMs), which are used to alter the surface of PGA to provide appropriate biological cues. IFBMs couple an affinity peptide for the material with a biologically active peptide that promotes desired cellular responses. One such PGA affinity peptide was coupled to the integrin binding domain, Arg-Gly-Asp (RGD), to build a chemically synthesized bimodular 27 amino acid peptide that mediated interactions between PGA and integrin receptors on endothelial cells. Quartz crystal microbalance with dissipation monitoring (QCMD) was used to determine the association constant (K (A) 1 x 10(7) M(-1)) and surface thickness (~3.5 nm). Cell binding studies indicated that IFBM efficiently mediated adhesion, spreading, and cytoskeletal organization of endothelial cells on PGA in an integrin-dependent manner. We show that the IFBM peptide promotes a 200% increase in endothelial cell binding to PGA as well as 70-120% increase in cell spreading from 30 to 60 minutes after plating.