Browsing by Author "Kontchou, Nelly-Ange"

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Open Access
A Comparative Sociological Investigation of the Conceptions and Perceptions of Mental Health and Illness in Arica, Chile and Rome, Italy
(2013-05-08) Kontchou, Nelly-Ange
This comparative study aimed to discover the principal factors that influence the perceptions of citizens in Arica, Chile and Rome, Italy toward mental illness. Specifically, the study aimed to investigate how these perceptions affect the societal acceptance of mentally ill individuals and to identify potential sources of stigma. In both cities, mental health services exist for free use by citizens, but stigma makes the use of these services and the acceptance of those who use them somewhat taboo. Past studies on the topic of mental health stigma have investigated the barriers to accessing mental health services (Acuña & Bolis 2005), the inception and effects of Basaglia’s Law (Tarabochia 2011), strategies to combat stigma (López et al. 2008) and images of mental illness in the media (Stout, Villeagas & Jennings 2004). To discover Aricans’ opinions on mental health and illness, personal interviews were administered to five mental health professionals, and a 20-question survey was administered to 131 members of the general population. In Rome, 27 subjects answered an 18-question survey as well as an interview, and 12 professionals participated in narrative interviews. From these interviews and surveys, the lack of economic, structural and human resources to effectively manage mental health programs was gleaned. Moreover, many participants identified how stigma infringed upon the human rights of those with mental illnesses and opined that they were barely accepted in society. Conclusions drawn were that stigma stems from multiple concurrent sources, and strategies to reduce it must align with each society’s unique needs. Stigma prevents people from caring for their mental health and from integrating those with mental illness.
Open Access
A Comparative Sociological Investigation of the Conceptions and Perceptions of Mental Health and Illness in Arica, Chile and Rome, Italy
(2013-11-12) Kontchou, Nelly-Ange
This comparative study aimed to discover the principal factors that influence the perceptions of citizens in Arica, Chile and Rome, Italy toward mental illness. Specifically, the study aimed to investigate how these perceptions affect the societal acceptance of mentally ill individuals and to identify potential sources of stigma. In both cities, mental health services exist for free use by citizens, but stigma makes the use of these services and the acceptance of those who use them somewhat taboo. Past studies on the topic of mental health stigma have investigated the barriers to accessing mental health services (Acuña & Bolis 2005), the inception and effects of Basaglia’s Law (Tarabochia 2011), strategies to combat stigma (López et al. 2008) and images of mental illness in the media (Stout, Villeagas & Jennings 2004). To discover Aricans’ opinions on mental health and illness, personal interviews were administered to five mental health professionals, and a 20-question survey was administered to 131 members of the general population. In Rome, 27 subjects answered an 18-question survey as well as an interview, and 12 professionals participated in narrative interviews. From these interviews and surveys, the lack of economic, structural and human resources to effectively manage mental health programs was gleaned. Moreover, many participants identified how stigma infringed upon the human rights of those with mental illnesses and opined that they were barely accepted in society. Conclusions drawn were that stigma stems from multiple concurrent sources, and strategies to reduce it must align with each society’s unique needs. Stigma prevents people from caring for their mental health and from integrating those with mental illness.
Open Access
UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling.
(Proc Natl Acad Sci U S A, 2013-08-20) Moore, Carlene; Cevikbas, Ferda; Pasolli, H Amalia; Chen, Yong; Kong, Wei; Kempkes, Cordula; Parekh, Puja; Lee, Suk Hee; Kontchou, Nelly-Ange; Yeh, Iwei; Jokerst, Nan Marie; Fuchs, Elaine; Steinhoff, Martin; Liedtke, Wolfgang B
At our body surface, the epidermis absorbs UV radiation. UV overexposure leads to sunburn with tissue injury and pain. To understand how, we focus on TRPV4, a nonselective cation channel highly expressed in epithelial skin cells and known to function in sensory transduction, a property shared with other transient receptor potential channels. We show that following UVB exposure mice with induced Trpv4 deletions, specifically in keratinocytes, are less sensitive to noxious thermal and mechanical stimuli than control animals. Exploring the mechanism, we find that epidermal TRPV4 orchestrates UVB-evoked skin tissue damage and increased expression of the proalgesic/algogenic mediator endothelin-1. In culture, UVB causes a direct, TRPV4-dependent Ca(2+) response in keratinocytes. In mice, topical treatment with a TRPV4-selective inhibitor decreases UVB-evoked pain behavior, epidermal tissue damage, and endothelin-1 expression. In humans, sunburn enhances epidermal expression of TRPV4 and endothelin-1, underscoring the potential of keratinocyte-derived TRPV4 as a therapeutic target for UVB-induced sunburn, in particular pain.