Browsing by Author "LeBlanc, Thomas W"
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Item Open Access A practical measurement of thoracic sarcopenia: correlation with clinical parameters and outcomes in advanced lung cancer.(ERJ Open Res, 2016-04) Wysham, Nicholas G; Nipp, Ryan D; LeBlanc, Thomas W; Wolf, Steven P; Ekstrom, Magnus P; Currow, David CThoracic sarcopenia can feasibly be measured from routine CT scans but does not correlate to patient-centred outcomes http://ow.ly/102UkQ.Item Open Access Facets of physical function assessed by patient-reported outcome measures in oncology research.(Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2024-04) Coles, Theresa; Fillipo, Rebecca; Plyler, Kate; Hernandez, Alexy; Henke, Debra M; Arizmendi, Cara; Cantrell, Sarah; Lagoo-Deenadayalan, Sandhya; Rory Goodwin, C; LeBlanc, Thomas W; Horodniceanu, Erica G; Bhatnagar, Vishal; Reeve, Bryce B; Weinfurt, KevinPurpose
The U.S. Food & Drug Administration has identified physical functioning (PF) as a core patient-reported outcome (PRO) in cancer clinical trials. The purpose of this study was to identify PF PRO measures (PROMs) in adult cancer populations and classify the PROMs by content covered (facets of PF) in each measure.Methods
As part of the Patient Reports of Physical Functioning Study (PROPS) research program, we conducted a targeted literature review to identify PROMs that could be used in clinical trials to evaluate PF from the patient perspective. Next, we convened an advisory panel to conduct a modified, reactive, Delphi study to reach consensus on which PF facets are assessed by PROMs identified in the review. The panel engaged in a "card sort" activity to classify PROM items by PF facets. Consensus was reached when 80% of panel members agreed that at least one facet was being measured by each PROM item.Results
The literature review identified 13 PROMs that met inclusion criteria. Eight facets of PF were identified for classification in the Delphi study: ability, completion, difficulty, limitation, quality, frequency, bother, and satisfaction. Through two rounds, the panel documented and classified conceptual approaches for each PRO item presented. The most prevalent PF facets were ability, difficulty, and limitation.Conclusion
Classifying PF PROMs by PF facets will promote more consistent communication regarding the aspects of PF represented in each PROM, helping researchers prioritize measures for inclusion in cancer clinical trials.Item Open Access Morphologic leukemia-free state in acute myeloid leukemia is sufficient for successful allogeneic hematopoietic stem cell transplant.(Blood cancer journal, 2021-05-16) Pabon, Cindy M; Li, Zhiguo; Hennig, Therese; de Castro, Carlos; Neff, Jadee L; Horwitz, Mitchell E; LeBlanc, Thomas W; Long, Gwynn D; Lopez, Richard D; Sung, Anthony D; Chao, Nelson; Gasparetto, Cristina; Sarantopoulos, Stefanie; Adams, Donna B; Erba, Harry; Rizzieri, David AItem Open Access Utilization of Text Messages to Supplement Rounding Communication: a Randomized Feasibility Study.(Journal of general internal medicine, 2022-09) Wesevich, Austin; Key-Solle, Mikelle; Kandakatla, Apoorva; Feeney, Colby; Pollak, Kathryn I; LeBlanc, Thomas WBackground
Fragmented communication with patients and families during hospitalizations often leaves patients confused about the daily plan.Objective
To pilot a supplemental text message-based platform for improving bidirectional communication about the clinical plan and patients' goals.Design
Randomized controlled trial PARTICIPANTS: Thirty adult patients, thirty caregivers of pediatric patients, and the interns caring for them on inpatient general medicine and pediatric services.Interventions
Patients and caregivers were texted or emailed daily to report their personal goal and assess their understanding of the team's clinical plan. Interns were texted daily to report the team's clinical plan and to assess their understanding of the patient's personal goal.Main measures
Primary outcomes were feasibility, defined as survey response rates, and acceptability. Secondary outcomes were patient comprehension of the clinical plan, trainee comprehension of the patient's goal, patient-centered communication scores, and educational satisfaction scores.Key results
Thirty adult patients, thirty caregivers of pediatric patients, fourteen general medicine interns, and six general pediatric interns enrolled. Intervention feasibility was met, with survey response rates of 80% for general medicine trainees, 67% for general pediatric trainees, 58% for adult patients, and 70% for caregivers. Patients and caregivers in the intervention arm had higher understanding of medication changes (76% vs 50%, p = 0.02) and new consultations (90% vs 61%, p = 0.002). Interns had higher understanding of patients' goals in the intervention arm (93% vs 40%, p < 0.001), particularly for adult patients (97% vs 17%, p < 0.001). Caregivers rated communication higher regarding information to help make decisions (p = 0.04). Interviews demonstrated high acceptability.Conclusions
Our text message-based communication intervention was feasible and acceptable to all involved participants, with preliminary signals of efficacy. The intervention may contribute to improved understanding of medication changes and new consultations, as well as help in making decisions. A large, randomized efficacy trial of this intervention is warranted. Graphical abstract.