Browsing by Author "Li, X"

Now showing 1 - 9 of 9
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    Compton scattering from 4He at 61 MeV
    (PRC, 2017-11-27) Sikora, MH; Ahmed, MW; Banu, A; Bartram, C; Crowe, B; Downie, EJ; Feldman, G; Gao, H; Grießhammer, HW; Hao, H; Howell, CR; Karwowski, HJ; Kendellen, DP; Kovash, MA; Li, X; Markoff, DM; Mikhailov, S; Popov, V; Pywell, RE; Silano, JA; Spraker, MC; Wallace, P; Weller, HR; Whisnant, CS; Wu, YK; Xiong, W; Yan, X; Zhao, ZW
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    Compton scattering from 4He at the TUNL HIγS facility
    (PRC, 2020-03-30) Li, X; Ahmed, MW; Banu, A; Bartram, C; Crowe, B; Downie, EJ; Emamian, M; Feldman, G; Gao, H; Godagama, D; Grießhammer, HW; Howell, CR; Karwowski, HJ; Kendellen, DP; Kovash, MA; Leung, KKH; Markoff, D; Mikhailov, S; Pywell, RE; Sikora, MH; Silano, JA; Sosa, RS; Spraker, MC; Swift, G; Wallace, P; Weller, HR; Whisnant, CS; Wu, YK; Zhao, ZW
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    Compton scattering from He 4 at the TUNL HIγ S facility
    (Physical Review C, 2020-03-01) Li, X; Ahmed, MW; Banu, A; Bartram, C; Crowe, B; Downie, EJ; Emamian, M; Feldman, G; Gao, H; Godagama, D; Grießhammer, HW; Howell, CR; Karwowski, HJ; Kendellen, DP; Kovash, MA; Leung, KKH; Markoff, D; Mikhailov, S; Pywell, RE; Sikora, MH; Silano, JA; Sosa, RS; Spraker, MC; Swift, G; Wallace, P; Weller, HR; Whisnant, CS; Wu, YK; Zhao, ZW
    © 2020 American Physical Society. Differential cross sections for elastic Compton scattering from He4 have been measured with high statistical precision at the High Intensity γ-ray Source at laboratory scattering angles of 55°, 90°, and 125° using a quasi-monoenergetic photon beam with a weighted mean energy value of 81.3 MeV. The results are compared to previous measurements and similar fore-aft asymmetry in the angular distribution of the differential cross sections is observed. This experimental work is expected to strongly motivate the development of effective-field-theory calculations of Compton scattering from He4 to fully interpret the data.
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    Correlates of Parent-Child Physiological Synchrony and Emotional Parenting: Differential Associations in Varying Interactive Contexts
    (Journal of Child and Family Studies, 2019-04-01) Han, ZR; Gao, MM; Yan, J; Hu, X; Zhou, W; Li, X
    © 2019, The Author(s). Objectives: Parent-child synchrony during interaction might possess important features that underlie parenting processes throughout development. However, little is known regarding the association between parent-child physiological synchrony and emotional parenting behaviors during middle childhood. The main goal of the study was to examine whether emotional parenting was positively or negatively associated with parent-child physiological synchrony for school-age children. Methods: Adopting a biopsychosocial perspective, we incorporated the interbeat interval (IBI) and behavioral observation data of 150 parent-child dyads (child M age = 8.77, SD= 1.80) to explore the patterns of moment-to-moment dyadic physiological synchrony and to investigate whether these patterns were associated with two emotional parenting behaviors (psychological control and psychological unavailability). Results: Our findings provided some initial evidence that in low to moderately stressful situations that mimic daily parent-child interaction, parent-child physiological synchrony was indicative of different emotional parenting behaviors in various parent-child interactive situations. Specifically, in the collaborative context (parent-child working together to complete a task), parent-child physiological synchrony was indicative of less psychological unavailability, whereas in the competitive context (parent-child resolving disagreement with each other), parent-child physiological synchrony was indicative of less psychological control. The study implications and future research directions are discussed. Conclusions: Overall, our findings suggested that dyadic physiological synchrony, indexed by parent-child moment-to-moment matching of IBI, was associated with fewer negative emotional parenting behaviors.
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    Genetic variants in the folate metabolic pathway genes predict melanoma-specific survival.
    (The British journal of dermatology, 2020-01-18) Dai, W; Liu, H; Liu, Y; Xu, X; Qian, D; Luo, S; Cho, E; Zhu, D; Amos, CI; Fang, S; Lee, JE; Li, X; Nan, H; Li, C; Wei, Q
    BACKGROUND:Folate metabolism plays an important role in DNA methylation and nucleic acid synthesis and thus may function as a regulatory factor in cancer development. Genome-wide association studies (GWAS) have identified some single-nucleotide polymorphisms (SNPs) associated with cutaneous melanoma-specific survival (CMSS), but no SNPs were found in genes involved in the folate metabolic pathway. OBJECTIVE:To examine associations between SNPs in folate metabolic pathway genes and CMSS. METHODS:We comprehensively evaluated 2,645 (422 genotyped and 2,223 imputed) common SNPs in folate metabolic pathway genes from a published GWAS of 858 patients from The University of Texas M.D. Anderson Cancer Center and performed the validation in another GWAS of 409 patients from the Nurses' Health Study and Health Professionals Follow-up Study, in which 95/858 (11.1%) and 48/409 (11.5%) patients died of cutaneous melanoma, respectively. RESULTS:We identified two independent SNPs (MTHFD1 rs1950902 G>A and ALPL rs10917006 C>T) to be associated with CMSS in both datasets, and their meta-analysis yielded an allelic hazards ratio of 1.75 (95% confidence interval=1.32-2.32, P=9.96×10-5 ) and 2.05 (1.39-3.01, P=2.84×10-4 ), respectively. The genotype-phenotype correlation analyses provided additional support for biologic plausibility of these two variants' roles in tumour progression, suggesting that variation in SNP-related mRNA expression levels is likely to be the mechanism underlying the observed associations with CMSS. CONCLUSION:Two possibly functional genetic variants, MTHFD1 rs1950902 and ALPL rs10917006, were likely to be independently or jointly associated with CMSS, which may add to personalized treatment in the future, once further validated.
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    Loss of PRDM1/BLIMP-1 function contributes to poor prognosis of activated B-cell-like diffuse large B-cell lymphoma.
    (Leukemia, 2017-03) Xia, Y; Xu-Monette, ZY; Tzankov, A; Li, X; Manyam, GC; Murty, V; Bhagat, G; Zhang, S; Pasqualucci, L; Visco, C; Dybkaer, K; Chiu, A; Orazi, A; Zu, Y; Richards, KL; Hsi, ED; Choi, WWL; van Krieken, JH; Huh, J; Ponzoni, M; Ferreri, AJM; Møller, MB; Parsons, BM; Winter, JN; Piris, MA; Westin, J; Fowler, N; Miranda, RN; Ok, CY; Li, Y; Li, J; Medeiros, LJ; Young, KH
    PRDM1/BLIMP-1, a master regulator of plasma-cell differentiation, is frequently inactivated in activated B-cell-like (ABC) diffuse large B-cell lymphoma (DLBCL) patients. Little is known about its genetic aberrations and relevant clinical implications. A large series of patients with de novo DLBCL was effectively evaluated for PRDM1/BLIMP-1 deletion, mutation, and protein expression. BLIMP-1 expression was frequently associated with the ABC phenotype and plasmablastic morphologic subtype of DLBCL, yet 63% of the ABC-DLBCL patients were negative for BLIMP-1 protein expression. In these patients, loss of BLIMP-1 was associated with Myc overexpression and decreased expression of p53 pathway molecules. In addition, homozygous PRDM1 deletions and PRDM1 mutations within exons 1 and 2, which encode for domains crucial for transcriptional repression, were found to show a poor prognostic impact in patients with ABC-DLBCL but not in those with germinal center B-cell-like DLBCL (GCB-DLBCL). Gene expression profiling revealed that loss of PRDM1/BLIMP-1 expression correlated with a decreased plasma-cell differentiation signature and upregulation of genes involved in B-cell receptor signaling and tumor-cell proliferation. In conclusion, these results provide novel clinical and biological insight into the tumor-suppressive role of PRDM1/BLIMP-1 in ABC-DLBCL patients and suggest that loss of PRDM1/BLIMP-1 function contributes to the overall poor prognosis of ABC-DLBCL patients.
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    Moderate Deviation for Random Elliptic PDEs with Small Noise
    (2017-04-23) Li, X; Liu, J; Lu, J; Zhou, X
    Partial differential equations with random inputs have become popular models to characterize physical systems with uncertainty coming from, e.g., imprecise measurement and intrinsic randomness. In this paper, we perform asymptotic rare event analysis for such elliptic PDEs with random inputs. In particular, we consider the asymptotic regime that the noise level converges to zero suggesting that the system uncertainty is low, but does exists. We develop sharp approximations of the probability of a large class of rare events.
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    Product selectivity in plasmonic photocatalysis for carbon dioxide hydrogenation
    (Nature Communications, 2017-02-23) Zhang, X; Li, X; Zhang, D; Su, NQ; Yang, W; Everitt, HO; Liu, J
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    Traction boundary conditions for molecular static simulations
    (Computer Methods in Applied Mechanics and Engineering, 2016-08-15) Li, X; Lu, J
    © 2016 Elsevier B.V.This paper presents a consistent approach to prescribe traction boundary conditions in atomistic models. Due to the typical multiple-neighbor interactions, finding an appropriate boundary condition that models a desired traction is a non-trivial task. We first present a one-dimensional example, which demonstrates how such boundary conditions can be formulated. We further analyze the stability, and derive its continuum limit. We also show how the boundary conditions can be extended to higher dimensions with an application to a dislocation dipole problem under shear stress.