Browsing by Author "Li, Zhuokai"

Now showing 1 - 3 of 3
  • Thumbnail Image
    ItemOpen Access
    Intensity of Lipid Lowering With Statin Therapy in Patients With Cerebrovascular Disease Versus Coronary Artery Disease: Insights from the PALM Registry.
    (Journal of the American Heart Association, 2019-10) Xian, Ying; Navar, Ann Marie; Li, Shuang; Li, Zhuokai; Robinson, Jennifer; Virani, Salim S; Louie, Michael J; Koren, Andrew; Goldberg, Anne; Roger, Veronique L; Wilson, Peter WF; Peterson, Eric D; Wang, Tracy Y
    Background Current treatment guidelines strongly recommend statin therapy for secondary prevention. However, it remains unclear whether patients' perceptions of cardiovascular risk, beliefs on cholesterol, or the intensity of prescribed statin therapy differs for patients with coronary artery disease (CAD) versus cerebrovascular disease (CeVD) versus both CAD and CeVD (CAD&CeVD). Methods and Results The PALM (Patient and Provider Assessment of Lipid Management) registry collected data on statin use, intensity, and core laboratory low-density lipoprotein cholesterol levels for 3232 secondary prevention patients treated at 133 US clinics. Among individuals with CeVD only (n=403), CAD only (n=2202), and CeVD&CAD (n=627), no significant differences were observed in patient-perceived cardiovascular disease risk, beliefs on cholesterol lowering, or perceived effectiveness and safety of statin therapy. However, patients with CeVD only were less likely to receive any statin therapy (76.2% versus 86.2%; adjusted odds ratio 0.64, 95% CI 0.45-0.91), or guideline-recommended statin intensity (34.6% versus 50.4%; adjusted odds ratio 0.60, 95% CI 0.45-0.81) than those with CAD only. Individuals with CeVD only were also less likely to achieve low-density lipoprotein cholesterol <100 mg/dL (59.2% versus 69.7%; adjusted odds ratio 0.79, 95% CI 0.64-0.99) than individuals with CAD alone. There were no significant differences in the use of any statin therapy or guideline-recommended statin intensity between individuals with CAD&CeVD and those with CAD only. Conclusions Despite lack of significant differences in patient-perceived cardiovascular risk or statin beliefs, patients with CeVD were significantly less likely to receive higher intensity statin or achieve low-density lipoprotein cholesterol <100 mg/dL than those with CAD only.
  • Thumbnail Image
    ItemOpen Access
    Rasch-calibrated Intermittent Exotropia Symptom Questionnaire for Children
    (Optometry and Vision Science, 2022-06) Holmes, Jonathan M; Leske, David A; Hercinovic, Amra; Hatt, Sarah R; Chandler, Danielle L; Li, Zhuokai; Melia, B Michele; Chen, Angela M; Erzurum, Sergul Ayse; Crouch, Eric R; Jenewein, Erin C; Kraker, Raymond T; Cotter, Susan A; Pediatric Eye Disease Investigator Group
  • Thumbnail Image
    ItemOpen Access
    Refractive Error Change and Overminus Lens Therapy for Childhood Intermittent Exotropia
    (JAMA Ophthalmology) Alexander, Monsey L; Allen, Megan; Alluri, Sreevardhan; Amster, Deborah M; Anderson, Heather A; Argoubi, Afifa; Astle, William F; Austin, Darrell S; Bailey, Maragaret K; Baker, John D; Beaulieu, Wesley T; Beck, Roy W; Berns, Fabiana; Bhatt, Amit R; Birch, Eileen E; Bitner, Derek P; Bland, Tracy A; Bodack, Marie I; Boente, Charline S; Bohra, Lisa; Bond, Lezlie L; Bothun, Erick D; Boyle, Nicole M; Brafford, Randy C; Castle, Kelly M; Chamberlain, Carolyn; Cheung, Nathan L; Christiansen, Stephen P; Christoff, Alex; Chung, Ida; Cioffi, Katherine R; Clausius, Deborah A; Cobb, Patricia; Collins, Mary Louise Z; Colon, Beth J; Conley, Julie A; Conner, Courtney L; Connolly, Katie S; Cooper, Karen; Crossnoe, Connie J; Crouch, Eric R; Cupit, Shawn L; Curtis, Linda T; Cutrer, Beth M; Davis, Barry; de Alba Campomanes, Alejandra G; De Leon, Erika A; Dean, Trevano W; Diener-West, Marie I; Dillon, Angela C; Dinani, Zainab; Donahue, Quayleen; Donahue, Sean P; Droste, Patrick J; Ecerova, Zuzana; Eltzroth, Jillian M; Esposito, Christina A; Evans, Patricia L; Everett, Donald F; Fang, Caroline C; Feis, Alicia E; Fergus, Lisa M; Fimbel, Brooke P; Fishman, Deborah R; Flanagan, Maureen A; Forde, Roberta A; Fouzdar Jain, Samisksha; Franklin, John Mark; Frazier, Marcela; Gafford, Jennifer B; Geddie, Brooke E; Gertsch, Kevin R; Gianfermi, Elena; Gray, Michael E; Grigorian, Adriana P; Gunton, Kammi B; Hahn, Alexis C; Hahn-Parrott, Laurie; Haider, Kathryn M; Haley, Wendy Jean; Hatch, Stanley W; Hatt, Sarah R; Henderson, Robert J; Heyman, Catherine L; Higgins, Rosemary D; Hilbrands, Jan; Hoepner, James E; Holleschau, Ann M; Holtorf, Hannah L; Hoover, Darren L; Hopkins, Kristine B; Huang, Kristine; Hutchinson, Amy K; James, Yvonne R; Jastrzemsbki, Benjamin G; Jenewein, Erin C; Jensen, Allison A; Jhajj, Jasleen K; Jones, Sarah K; Jordan, Catherine O; Kaplon, Joseph D; Khan, Shabana; Klaehn, Lindsay D; Kong, Lingkun; Koontz, Emily R; Koutnik, Cassandra A; Kramer, Andrea M; Kraus, Courtney L; Krueger, Samantha L; Kulp, Marjean T; Kurup, Sudhi P; LaMattina, Kara C; Lambert, Jennifer E; Lambert, Scott R; Law, Cristina L; Lazar, Elizabeth L; Leach, Shelby; Lee, Katherine A; Leske, David A; Li, Zhuokai; Lim, Maria E; Liu, Xiaonong; Lorenzana, Ingryd; Loud, Rachel N; Lyon, Don W; Lyons, Alex F; Manuchian, Sonia; Marozas, Lauren; Marsh, Justin D; Martinson, Stacy R; May, Laura M; McCoy Vrablec, Laura; McMurtrey, J Ryan; Meil, Gail C; Melia, B Michele; Merrill, Kim S; Mets-Halgrimson, Rebecca B; Meyers, Sara R; Miller, Aaron M; Miller, Caiytlin C; Mohney, Brian G; Montejo, Jenifer; Morgan, Linda; Morrison, Kelsie B; Morrison, Ann M; Morrison, David G; Myung, Jenny; Nash, David L; Nylin, Elyse; Oechslin, Tamara S; Olvera, Maria N; Ortiz, Gillaine; Oseguera, Teresa; Pang, Yi; Parker, Sue M; Patel, Reena A; Paysse, Evelyn A; Peragallo, Jason H; Perzyk, Susan N; Peters, Robert J; Phillips, Paul H; Plaumann, Maureen D; Plum, Larry W; Poff, Stephen W; Pollack, Karen E; Qayum, Jennifer N; Quebbemann, Micaela N; Raghuram, Aparna; Rahmani, Bahram; Ralay Ranaivo, Hantamalala; Repka, Michael X; Retnasothie, Dashaini V; Roberts, Tawna L; Robinson, Julianne L; Roe, Matthew K; Romany, Gihan; Rutner, Daniella; Sala, Allyson; Sanders, Emi N; Saunders, Richard A; Sayani, Amar; Scheiman, Mitchell M; Schulman-Ellis, Erica L; Shah, Birva K; Shah, Veeral S; Shelton, Erica R; Siatkowski, R Michael; Slinger, Kristin E; Smith, Rachel M; Solis, Casandra S; Stec, Magdalena; Stevens, Nancy E; Stevens, Julia L; Stewart, Miqua L; Strul, Sasha; Stutz, Kathleen M; Suh, Donny W; Summers, Allison I; Superstein, Roseanne; Sutherland, Desirae R; Tamkins, Susanna M; Taub, Marc B; Thibeault, Maryse; Titelbaum, Jenna R; Tolbert, Tiffany T; Toole, Andrew J; Toro, David O; Tung, Irene T; Twardowski, Christina M; Tychsen, Lawrence; Tzanetakos, Vivian; Varney, Kelly D; Ventura, Gaylord G; Verderber, Lisa C; Walker, Kimberly R; Wall, Palak B; Wallace, David K; Wang, Jingyun; Weise, Katherine K; Wernimont, Suzanne M; Willen, Christi M; Wolinski, Elisabeth T; Woodard, Victoria C; Wright, Martha M; Yamada, Tomohiko; Yen, Kimberly G; Yonkers, Amanda M; Freedman, Sharon F; Christian, Melanie L; Crouch, Earl R; Enyedi, Laura B; Good, William V; Jackson, Jorie L; London, Richard; Manh, Vivian M; Manny, Ruth E; Morrell, Beth A; Petersen, David B; Pineles, Stacy L; Rogers, David L; Ruark, Scott T; Schweinler, Bonita R; Silver, Jayne L; Chen, Angela M; Erzurum, S Ayse; Chandler, Danielle L; Hercinovic, Amra; Wu, Rui; Vricella, Marilyn; Waters, Amy L; Ticho, Benjamin H; Erickson, John W; Han, Silvia; McDowell, Paula S; Li, Zhuokai; Kraker, Raymond T; Holmes, Jonathan M; Cotter, Susan A
    ImportanceIncreased myopic shift was found to be associated with 1 year of overminus spectacle treatment for children with intermittent exotropia (IXT). Persistence of myopic shift after discontinuing overminus spectacles is unknown.ObjectiveTo compare refractive error change over 3 years in children with IXT originally treated with overminus vs nonoverminus spectacles.Design, Setting, and ParticipantsThis study was an 18-month extension of the Trial of Overminus Spectacle Therapy for Intermittent Exotropia cohort, which previously randomized children aged 3 to 10 years with IXT and baseline spherical equivalent refractive error (SER) between −6.00 diopters (D) and 1.00 D to overminus spectacles (−2.50 D for 12 months, −1.25 D for 3 months, and nonoverminus for 3 months) or nonoverminus spectacles. Children were recruited from 56 sites from July 2010 to February 2022. Data were analyzed from February 2022 to January 2024.InterventionsAfter trial completion at 18 months, participants were followed up at 24 and 36 months. Treatment was at investigator discretion from 18 to 36 months.Main Outcomes and MeasuresChange in SER (cycloplegic retinoscopy) from baseline to 36 months.ResultsOf 386 children in the Trial of Overminus Spectacle Therapy for Intermittent Exotropia, 223 (57.8%) consented to 18 months of additional follow-up, including 124 of 196 (63.3%) in the overminus treatment group and 99 of 190 (52.1%) in the nonoverminus treatment group. Of 205 children who completed 36-month follow-up, 116 (56.6%) were female, and the mean (SD) age at randomization was 6.2 (2.1) years. Mean (SD) SER change from baseline to 36 months was greater in the overminus group (−0.74 [1.00] D) compared with the nonoverminus group (−0.44 [0.85] D; adjusted difference, −0.36 D; 95% CI, −0.59 to −0.12; P = .003), with 30 of 112 (26.8%) in the overminus group having more than 1 D of myopic shift compared with 14 of 91 (15%) in the nonoverminus group (risk ratio, 1.8; 95% CI, 1.0-3.0). From 12 to 36 months, mean (SD) myopic shift was −0.34 (0.67) D and −0.36 (0.66) D in the overminus and nonoverminus groups, respectively (adjusted difference, −0.001 D; 95% CI, −0.18 to 0.18; P = .99).Conclusions and RelevanceThe greater myopic shift observed after 1 year of −2.50-D overminus lens treatment remained at 3 years. Both groups had similar myopic shift during the 2-year period after treatment weaning and cessation. The risk of myopic shift should be discussed with parents when considering overminus lens treatment.Trial RegistrationClinicalTrials.gov Identifier: NCT02807350