Browsing by Author "Lin, Chenchu"

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    SGC-CAMKK2-1: A Chemical Probe for CAMKK2.
    (Cells, 2023-01) Wells, Carrow; Liang, Yi; Pulliam, Thomas L; Lin, Chenchu; Awad, Dominik; Eduful, Benjamin; O'Byrne, Sean; Hossain, Mohammad Anwar; Catta-Preta, Carolina Moura Costa; Ramos, Priscila Zonzini; Gileadi, Opher; Gileadi, Carina; Couñago, Rafael M; Stork, Brittany; Langendorf, Christopher G; Nay, Kevin; Oakhill, Jonathan S; Mukherjee, Debarati; Racioppi, Luigi; Means, Anthony R; York, Brian; McDonnell, Donald P; Scott, John W; Frigo, Daniel E; Drewry, David H
    The serine/threonine protein kinase calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) plays critical roles in a range of biological processes. Despite its importance, only a handful of inhibitors of CAMKK2 have been disclosed. Having a selective small molecule tool to interrogate this kinase will help demonstrate that CAMKK2 inhibition can be therapeutically beneficial. Herein, we disclose SGC-CAMKK2-1, a selective chemical probe that targets CAMKK2.