Browsing by Author "Marion, Eve"

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    Approaches for enhancing the informativeness and quality of clinical trials: Innovations and principles for implementing multicenter trials from the Trial Innovation Network.
    (Journal of clinical and translational science, 2023-01) Lane, Karen; Palm, Marisha E; Marion, Eve; Kay, Marie T; Thompson, Dixie; Stroud, Mary; Boyle, Helen; Hillery, Shannon; Nanni, Angeline; Hildreth, Meghan; Nelson, Sarah; Burr, Jeri S; Edwards, Terri; Poole, Lori; Waddy, Salina P; Dunsmore, Sarah E; Harris, Paul; Wilkins, Consuelo; Bernard, Gordon R; Dean, J Michael; Dwyer, Jamie; Benjamin, Daniel K; Selker, Harry P; Hanley, Daniel F; Ford, Daniel E
    One challenge for multisite clinical trials is ensuring that the conditions of an informative trial are incorporated into all aspects of trial planning and execution. The multicenter model can provide the potential for a more informative environment, but it can also place a trial at risk of becoming uninformative due to lack of rigor, quality control, or effective recruitment, resulting in premature discontinuation and/or non-publication. Key factors that support informativeness are having the right team and resources during study planning and implementation and adequate funding to support performance activities. This communication draws on the experience of the National Center for Advancing Translational Science (NCATS) Trial Innovation Network (TIN) to develop approaches for enhancing the informativeness of clinical trials. We distilled this information into three principles: (1) assemble a diverse team, (2) leverage existing processes and systems, and (3) carefully consider budgets and contracts. The TIN, comprised of NCATS, three Trial Innovation Centers, a Recruitment Innovation Center, and 60+ CTSA Program hubs, provides resources to investigators who are proposing multicenter collaborations. In addition to sharing principles that support the informativeness of clinical trials, we highlight TIN-developed resources relevant for multicenter trial initiation and conduct.
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    Designing and Implementing a Community-Engaged Research e-Library: A Case Study for Adapting Academic Library Information Infrastructure to Respond to Stakeholder Needs
    (College and Research Libraries, 2025-01-01) Efird-Green, Lea; Marion, Eve; Gierisch, Jennifer; Willis, Diane; Corsino, Leonor
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    Participatory research to improve medication reconciliation for older adults in the community.
    (Journal of the American Geriatrics Society, 2023-02) Doucette, Lorna; Kiely, Bridget T; Gierisch, Jennifer M; Marion, Eve; Nadler, Lisa; Heflin, Mitchell T; Upchurch, Gina

    Introduction

    Medication reconciliation, a technique that assists in aligning a care team's understanding of an individual's true medication regimen, is vital to optimize medication use and prevent medication errors. Historically, most medication reconciliation research has focused on institutional settings and transitional care, with comparatively little attention given to medication reconciliation in community settings. To optimize medication reconciliation for community-dwelling older adults, healthcare professionals and older adults must be engaged in co-designing processes that create sustainable approaches.

    Methods

    Academic researchers, older adults, and community- and health system-based healthcare professionals engaged in a participatory process to better understand medication reconciliation barriers and co-design solutions. The initiative consisted of two participatory research approaches: (1) Sparks Innovation Studios, which synthesized professional expertise and opinions, and (2) a Community Consultation Studio with older adults. Input from both groups informed a list of possible solutions and these were ranked based on evaluative criteria of feasibility, person-centeredness, equity, and sustainability.

    Results

    Sparks Innovation Studios identified a lack of ownership, fragmented healthcare systems, and time constraints as the leading barriers to medication reconciliation. The Community Consultation Studio revealed that older adults often feel dismissed in medical encounters and perceive poor communication with and among providers. The Community Consultation Studio and Sparks Innovation Studios resulted in four highly-ranked solutions to improve medication reconciliation: (1) support for older adults to improve health literacy and ownership; (2) ensuring medication indications are included on prescription labels; (3) trainings and incentives for front-line staff in clinic settings to become champions for medication reconciliation; and (4) electronic health record improvements that simplify active medication lists.

    Conclusion

    Engaging community representatives with academic partners in the research process enhanced understanding of community priorities and provided a practical roadmap for innovations that have the potential to improve the well-being of community-dwelling older adults.