Browsing by Author "Mestre, Tiago A"
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Item Open Access A Unified Framework for Evidence-Based Diagnostic Criteria Programs in Movement Disorders.(Movement disorders : official journal of the Movement Disorder Society, 2023-07) Mestre, Tiago A; Fabbri, Margherita; Luo, Sheng; Stebbins, Glenn T; Goetz, Christopher G; Sampaio, CristinaItem Open Access Co-Existent Probable RBD and PD: Disease Progression, Medication Response, and Clinical Trial Implications(Movement Disorders Clinical Practice, 2023-01-01) Zou, Haotian; Guo, Yuanyuan; Goetz, Christopher G; Mestre, Tiago A; Stebbins, Glenn T; Al-Hajraf, Falah; Lawton, Michael; Hu, Michele; Luo, ShengItem Open Access It Is as It Was: MDS-UPDRS Part III Scores Cannot Be Combined with Other Parts to Give a Valid Sum.(Movement disorders : official journal of the Movement Disorder Society, 2022-12) Goetz, Christopher G; Choi, Dongrak; Guo, Yuanyuan; Stebbins, Glenn T; Mestre, Tiago A; Luo, ShengBackground
Original clinimetric analyses by the Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) developers did not confirm the validity of summing the scores of its parts. Recent studies used the summed score of Part III and other parts as efficacy outcomes.Objective
The aim of this study was to establish whether summing scores of MDS-UPDRS parts can be recommended.Methods
Using 7466 full MDS-UPDRS scores, we applied two-step factor analysis as in the original article to reassess the validity analysis with the threshold criterion set at comparative fit index ≥0.9.Results
All comparative fit indexes of any combination including Part III were lower than 0.90.Conclusions
Summing Part III MDS-UPDRS scores with other parts is not clinimetrically sound. The MDS-UPDRS is a validated four-part scale with corresponding individual part scores and needs to be used within the limits originally presented. © 2022 International Parkinson and Movement Disorder Society.Item Open Access MDS‐UPDRS Motor Examination retains its two‐domain profile in both ON and OFF(Movement Disorders Clinical Practice) Guo, Yuanyuan; Stebbins, Glenn T; Mestre, Tiago A; Goetz, Christopher G; Luo, ShengItem Open Access Reply to: "The Framework for Diagnostic Criteria in Movement Disorders: The Value of Methodological Tools and Combined Criteria".(Movement disorders : official journal of the Movement Disorder Society, 2023-09) Mestre, Tiago A; Luo, Sheng; Stebbins, Glenn T; Sampaio, Cristina; Goetz, Christopher GItem Open Access Reply to: Comment on "Summing MDS-UPDRS Parts 1 + 2 (Non-motor and Motor Experience of Daily Living): The Patient's Voice".(Movement disorders : official journal of the Movement Disorder Society, 2023-08) Goetz, Christopher G; Zou, Haotian; Stebbins, Glenn T; Schrag, Anette; Mestre, Tiago A; Luo, ShengItem Open Access Resolving Missing Data from the Movement Disorder Society Unified Parkinson's Disease Rating Scale: Implications for Telemedicine.(Movement disorders : official journal of the Movement Disorder Society, 2022-06-18) Luo, Sheng; Goetz, Christopher G; Choi, Dongrak; Aggarwal, Sanket; Mestre, Tiago A; Stebbins, Glenn TBackground
Telemedicine has become standard in clinical care and research during the coronavirus disease 2019 pandemic. Remote administration of Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part III (Motor Examination) precludes ratings of all items, because Rigidity and Postural Stability (six scores) require in-person rating.Objective
The objective of this study was to determine imputation accuracy for total-sum and item-specific MDS-UPDRS Motor Examination scores in remote administration.Methods
We applied multivariate imputation by chained equations techniques in a cross-sectional dataset where patients had one MDS-UPDRS rating (International Translational Program, n = 8,588) and in a longitudinal dataset where patients had multiple ratings (Rush Program, n = 396). Successful imputation was stringently defined as (1) generalized Lin's concordance correlation coefficient >0.95, reflecting near-perfect agreement between total-sum score with complete data and surrogate score, calculated without patients' actual Rigidity and Postural Stability scores; and (2) perfect agreement for item-level scores for Rigidity and Postural Stability items.Results
For total-sum score when Rigidity and Postural Stability scores were withdrawn, using one or multiple visits, multivariate imputation by chained equations imputation reached near-perfect agreement with the original total-sum score. However, at the item level, the degree of perfect agreement between the surrogate and actual Rigidity items and Postural Stability scores always fell below threshold.Conclusions
The MDS-UPDRS Part III total-sum score, a key clinical outcome in research and in clinical practice, can be accurately imputed without the Rigidity and Postural Stability items that cannot be rated by telemedicine. No formula, however, allows for specific item-level imputation. When Rigidity and Postural Stability item scores are of key clinical or research interest, patients with PD must be scored in person. © 2022 International Parkinson and Movement Disorder Society.Item Open Access Summing MDS-UPDRS Parts 1 + 2 (Non-motor and Motor Experience of Daily Living): The Patient's Voice.(Movement disorders : official journal of the Movement Disorder Society, 2023-04) Zou, Haotian; Goetz, Christopher G; Stebbins, Glenn T; Schrag, Anette; Mestre, Tiago A; Luo, ShengItem Open Access Using Movement Disorder Society Unified Parkinson's Disease Rating Scale Parts 2 and 3 Simultaneously: Combining the Patient Voice with Clinician Ratings(Movement Disorders) Guo, Yuanyuan; Goetz, Christopher G; Stebbins, Glenn T; Mestre, Tiago A; Luo, Sheng