Browsing by Author "Nosé, Brent D"

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    Buccal reharvest for urethroplasty after graft site closure is safe and does not affect long-term oral health
    (Urology, 2022-01) Inouye, Brian M; Nosé, Brent D; Krughoff, Kevin; Boysen, William R; Peterson, Andrew C
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    Extirpative cultures reveal infectious pubic bone osteomyelitis in prostate cancer survivors with urinary-pubic symphysis fistulae (UPF).
    (Urology, 2020-05-07) Nosé, Brent D; Boysen, William R; Kahokehr, Arman A; Inouye, Brian M; Eward, William C; Hendershot, Edward F; Peterson, Andrew C
    OBJECTIVE:To examine the infectious features of patients with urinary pubic symphysis fistula (UPF) and their association with osteomyelitis. METHODS:We conducted a review of our quality improvement database for 36 patients with UPF undergoing bone resection and extirpative surgery from October 2012 to January 2019. An assessment of bone and urine cultures was carried out along with surgical, radiologic and demographic data. We analyzed descriptive statistics and used Fisher Exact Tests and unpaired Welch t-tests to assess for associations with positive bone cultures. RESULTS:In our cohort, 33 patients (91.7%) had positive bone cultures with the three most common organisms being candida (22.0%), enterococcus (18.0%) and pseudomonas (10.0%). There was a correlation between positive pre-operative urine culture and positive bone culture (p< 0.01), with 63.0% of those with positive urine cultures growing the same organism on bone culture. CONCLUSIONS:In this series, 91.7% of patients undergoing extirpative surgery for UPF at our institution have positive bone cultures at time of pubic bone debridement. Additionally, we demonstrate a statistically significant correlation between positive urine cultures and positive bone cultures in these patients. This supports the need for a multidisciplinary approach including infectious disease, orthopedic surgery and reconstructive urology in order to address this complex clinical condition.
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    Intrinsic Plasma Cell Differentiation Defects in B Cell Expansion with NF-κB and T Cell Anergy Patient B Cells
    (Frontiers in Immunology, 2017) Arjunaraja, Swadhinya; Nosé, Brent D; Sukumar, Gauthaman; Lott, Nathaniel M; Dalgard, Clifton L; Snow, Andrew L
    BENTA (B cell Expansion with NF-κB and T cell Anergy) disease is a novel B cell lymphoproliferative disorder caused by germline, gain-of-function mutations in the lymphocyte scaffolding protein CARD11, which drives constitutive NF-κB signaling. Despite dramatic polyclonal expansion of naïve and immature B cells, BENTA patients also present with signs of primary immunodeficiency, including markedly reduced percentages of class-switched/memory B cells and poor humoral responses to certain vaccines. Using purified naïve B cells from our BENTA patient cohort, here we show that BENTA B cells exhibit intrinsic defects in B cell differentiation. Despite a profound in vitro survival advantage relative to normal donor B cells, BENTA patient B cells were severely impaired in their ability to differentiate into short-lived IgDloCD38hi plasmablasts or CD138+ long-lived plasma cells in response to various stimuli. These defects corresponded with diminished IgG antibody production and correlated with poor induction of specific genes required for plasma cell commitment. These findings provide important mechanistic clues that help explain both B cell lymphocytosis and humoral immunodeficiency in BENTA disease.
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    Synchronous Hemihepatectomy With Pancreatectomy Through Application of Associated Liver Partition and Portal Vein Ligation for a Metastatic Gastrinoma.
    (The American surgeon, 2020-10-30) Nosé, Brent D; Ottmann, Shane E; Lauria, Alexis L; Hawksworth, Jason S
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    Urinary pubic symphysis fistula leads to histopathologic osteomyelitis in prostate cancer survivors
    (Urology, 2020-08) Kahokehr, Arman A; Boysen, William R; Schild, Michael H; Nosé, Brent D; Huang, Jiaoti; Eward, Will; Peterson, Andrew C