Browsing by Author "Patel, Keyur"

Now showing 1 - 4 of 4
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    A Review of the Natural History of Chronic Hepatitis C Infection
    (North American Journal of Medicine and Science, 2014) Wilder, Julius; Patel, Keyur
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    Acute liver failure in the setting of herpes simplex virus and coexistent acute fatty liver of pregnancy
    (Case Reports in Clinical Pathology, 2014-12-03) Wilder, Julius; Chang, Sydney; Cardona, Diana; Patel, Keyur; Brady, Carla
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    Antiretroviral Effects on Host Lipoproteins Are Associated With Changes in Hepatitis C Virus (HCV) RNA Levels in Human Immunodeficiency Virus/HCV Coinfected Individuals.
    (Open forum infectious diseases, 2015-04) Naggie, Susanna; Patel, Keyur; Yang, Lan-Yan; Chow, Shein-Chung; Johnson, Victoria; Guyton, John R; Muir, Andrew J; Sulkowski, Mark; Hicks, Charles
    We evaluated the impact of antiretroviral-induced dyslipidemia on hepatitis C virus (HCV) biogenesis in human immunodeficiency virus (HIV)/HCV coinfected patients. This study used serum samples from antiretroviral-naive HIV/HCV patients initiating their first regimen as part of AIDS Clinical Trials Group study protocols (A5142, A5202). Initiation of antiretrovirals increased most lipoproteins and apolipoproteins. In the multivariable model, changes in apolipoproteins were associated with changes in log10 HCV RNA from baseline to week-24 of therapy. Off-target lipogenic changes need to be considered in the context of liver and other metabolic disease in HIV/HCV patients.
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    The clinical utility of FibroScan(®) as a noninvasive diagnostic test for liver disease.
    (Med Devices (Auckl), 2014) Wilder, Julius; Patel, Keyur
    An important aspect of managing chronic liver disease is assessing for evidence of fibrosis. Historically, this has been accomplished using liver biopsy, which is an invasive procedure associated with risk for complications and significant sampling and observer error, limiting the accuracy for determination of fibrosis stage. Hence, several serum biomarkers and imaging methods for noninvasive assessment of liver fibrosis have been developed. In this article, we review the current literature on an important noninvasive imaging modality to measure tissue elastography (FibroScan(®)). This ultrasound-based technique is now increasingly available in many countries and has been shown to be a reliable and safe noninvasive means of assessing disease severity in chronic liver disease of varying etiology.