Browsing by Author "Strickland, Kyle C"
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Item Open Access Acyl Carrier Protein-specific 4'-Phosphopantetheinyl Transferase Activates 10-Formyltetrahydrofolate Dehydrogenase(Journal of Biological Chemistry, 2010-01-15) Strickland, Kyle C; Hoeferlin, L Alexis; Oleinik, Natalia V; Krupenko, Natalia I; Krupenko, Sergey AItem Open Access ALDH1L2 Is the Mitochondrial Homolog of 10-Formyltetrahydrofolate Dehydrogenase(Journal of Biological Chemistry, 2010-07-23) Krupenko, Natalia I; Dubard, Marianne E; Strickland, Kyle C; Moxley, Kelly M; Oleinik, Natalia V; Krupenko, Sergey AItem Open Access Association and prognostic significance of BRCA1/2-mutation status with neoantigen load, number of tumor-infiltrating lymphocytes and expression of PD-1/PD-L1 in high grade serous ovarian cancer(Oncotarget, 2017-07-13) Strickland, Kyle C; Howitt, Brooke E; Shukla, Sachet A; Rodig, Scott; Ritterhouse, Lauren L; Liu, Joyce F; Garber, Judy E; Chowdhury, Dipanjan; Wu, Catherine J; D'Andrea, Alan D; Matulonis, Ursula A; Konstantinopoulos, Panagiotis AItem Open Access Association of Polymerase e–Mutated and Microsatellite-Instable Endometrial Cancers With Neoantigen Load, Number of Tumor-Infiltrating Lymphocytes, and Expression of PD-1 and PD-L1(JAMA Oncology, 2015-12-01) Howitt, Brooke E; Shukla, Sachet A; Sholl, Lynette M; Ritterhouse, Lauren L; Watkins, Jaclyn C; Rodig, Scott; Stover, Elizabeth; Strickland, Kyle C; D'Andrea, Alan D; Wu, Catherine J; Matulonis, Ursula A; Konstantinopoulos, Panagiotis AItem Open Access Brachytherapy via a depot of biopolymer-bound 131I synergizes with nanoparticle paclitaxel in therapy-resistant pancreatic tumours.(Nature biomedical engineering, 2022-10) Schaal, Jeffrey L; Bhattacharyya, Jayanta; Brownstein, Jeremy; Strickland, Kyle C; Kelly, Garrett; Saha, Soumen; Milligan, Joshua; Banskota, Samagya; Li, Xinghai; Liu, Wenge; Kirsch, David G; Zalutsky, Michael R; Chilkoti, AshutoshLocally advanced pancreatic tumours are highly resistant to conventional radiochemotherapy. Here we show that such resistance can be surmounted by an injectable depot of thermally responsive elastin-like polypeptide (ELP) conjugated with iodine-131 radionuclides (131I-ELP) when combined with systemically delivered nanoparticle albumin-bound paclitaxel. This combination therapy induced complete tumour regressions in diverse subcutaneous and orthotopic mouse models of locoregional pancreatic tumours. 131I-ELP brachytherapy was effective independently of the paclitaxel formulation and dose, but external beam radiotherapy (EBRT) only achieved tumour-growth inhibition when co-administered with nanoparticle paclitaxel. Histological analyses revealed that 131I-ELP brachytherapy led to changes in the expression of intercellular collagen and junctional proteins within the tumour microenvironment. These changes, which differed from those of EBRT-treated tumours, correlated with the improved delivery and accumulation of paclitaxel nanoparticles within the tumour. Our findings support the further translational development of 131I-ELP depots for the synergistic treatment of localized pancreatic cancer.Item Open Access Clear cell ovarian cancers with microsatellite instability: A unique subset of ovarian cancers with increased tumor-infiltrating lymphocytes and PD-1/PD-L1 expression(OncoImmunology, 2017-02) Howitt, Brooke E; Strickland, Kyle C; Sholl, Lynette M; Rodig, Scott; Ritterhouse, Lauren L; Chowdhury, Dipanjan; D'Andrea, Alan D; Matulonis, Ursula A; Konstantinopoulos, Panagiotis AItem Open Access Enzymatic properties of ALDH1L2, a mitochondrial 10-formyltetrahydrofolate dehydrogenase(Chemico-Biological Interactions, 2011-05) Strickland, Kyle C; Krupenko, Natalia I; Dubard, Marianne E; Hu, Calvin J; Tsybovsky, Yaroslav; Krupenko, Sergey AItem Open Access Frequency of “incidental” serous tubal intraepithelial carcinoma (STIC) in women without a history of or genetic risk factor for high-grade serous carcinoma: A six-year study(Gynecologic Oncology, 2017-07) Meserve, Emily EK; Mirkovic, Jelena; Conner, James R; Yang, Eric; Muto, Michael G; Horowitz, Neil; Strickland, Kyle C; Howitt, Brooke E; Crum, Christopher PItem Open Access Molecular mechanisms underlying the potentially adverse effects of folate(Clinical Chemistry and Laboratory Medicine, 2013-01-01) Strickland, Kyle C; Krupenko, Natalia I; Krupenko, Sergey AItem Open Access Morphologic correlates of molecular alterations in extrauterine Müllerian carcinomas(Modern Pathology, 2016-08) Ritterhouse, Lauren L; Nowak, Jonathan A; Strickland, Kyle C; Garcia, Elizabeth P; Jia, Yonghui; Lindeman, Neal I; Macconaill, Laura E; Konstantinopoulos, Panagiotis A; Matulonis, Ursula A; Liu, Joyce; Berkowitz, Ross S; Nucci, Marisa R; Crum, Christopher P; Sholl, Lynette M; Howitt, Brooke EItem Open Access Noninvasive Follicular Variant of Papillary Thyroid Carcinoma and the Afirma Gene-Expression Classifier(Thyroid, 2016-07) Wong, Kristine S; Angell, Trevor E; Strickland, Kyle C; Alexander, Erik K; Cibas, Edmund S; Krane, Jeffrey F; Barletta, Justine AItem Open Access Phylogeny and evolution of aldehyde dehydrogenase-homologous folate enzymes(Chemico-Biological Interactions, 2011-05) Strickland, Kyle C; Holmes, Roger S; Oleinik, Natalia V; Krupenko, Natalia I; Krupenko, Sergey AItem Open Access Preoperative Cytologic Diagnosis of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features: A Prospective Analysis(Thyroid, 2016-10) Strickland, Kyle C; Vivero, Marina; Jo, Vickie Y; Lowe, Alarice C; Hollowell, Monica; Qian, Xiaohua; Wieczorek, Tad J; French, Christopher A; Teot, Lisa A; Sadow, Peter M; Alexander, Erik K; Cibas, Edmund S; Barletta, Justine A; Krane, Jeffrey FItem Open Access Prevalence of Contralateral Tumors in Patients with Follicular Variant of Papillary Thyroid Cancer(Journal of the American College of Surgeons, 2017-06) Sullivan, Michael C; Graham, Paul H; Alexander, Erik K; Ruan, Daniel T; Nehs, Matthew A; Gawande, Atul A; Moore, Francis D; Howitt, Brooke E; Strickland, Kyle C; Krane, Jeffrey F; Barletta, Justine A; Cho, Nancy LItem Open Access Protein interactions among the vaccinia virus late transcription factors(Virology, 2004-11) Dellis, Stephanie; Strickland, Kyle C; McCrary, William J; Patel, Ashwin; Stocum, Eileen; Wright, Cynthia FItem Open Access Qualifiers of atypia in the cytologic diagnosis of thyroid nodules are associated with different Afirma gene expression classifier results and clinical outcomes(Cancer Cytopathology, 2017-05) Baca, Sylvan C; Wong, Kristine S; Strickland, Kyle C; Heller, Howard T; Kim, Matthew I; Barletta, Justine A; Cibas, Edmund S; Krane, Jeffrey F; Marqusee, Ellen; Angell, Trevor EItem Open Access Solitary Fibrous Tumor of the Uterus Presenting With Lung Metastases(International Journal of Gynecological Pathology, 2016-01) Strickland, Kyle C; Nucci, Marisa R; Esselen, Katharine M; Muto, Michael G; Chopra, Sameer; George, Suzanne; Howitt, Brooke EItem Open Access Suggesting the cytologic diagnosis of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): A retrospective analysis of atypical and suspicious nodules(Cancer Cytopathology, 2017-09-27) Strickland, Kyle C; Howitt, Brooke E; Barletta, Justine A; Cibas, Edmund S; Krane, Jeffrey FItem Open Access The Flip Side of NIFTP: an Increase in Rates of Unfavorable Histologic Parameters in the Remainder of Papillary Thyroid Carcinomas(Endocrine Pathology, 2017-06) Wong, Kristine S; Strickland, Kyle C; Angell, Trevor E; Nehs, Matthew A; Alexander, Erik K; Cibas, Edmund S; Krane, Jeffrey F; Howitt, Brooke E; Barletta, Justine AItem Open Access The Impact of Noninvasive Follicular Variant of Papillary Thyroid Carcinoma on Rates of Malignancy for Fine-Needle Aspiration Diagnostic Categories(Thyroid, 2015-09) Strickland, Kyle C; Howitt, Brooke E; Marqusee, Ellen; Alexander, Erik K; Cibas, Edmund S; Krane, Jeffrey F; Barletta, Justine A