Browsing by Author "Suthana, Nanthia"
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Item Open Access A pilot study of closed-loop neuromodulation for treatment-resistant post-traumatic stress disorder(Nature Communications) Gill, Jay L; Schneiders, Julia A; Stangl, Matthias; Aghajan, Zahra M; Vallejo, Mauricio; Hiller, Sonja; Topalovic, Uros; Inman, Cory S; Villaroman, Diane; Bari, Ausaf; Adhikari, Avishek; Rao, Vikram R; Fanselow, Michael S; Craske, Michelle G; Krahl, Scott E; Chen, James WY; Vick, Merit; Hasulak, Nicholas R; Kao, Jonathan C; Koek, Ralph J; Suthana, Nanthia; Langevin, Jean-PhilippeAbstractThe neurophysiological mechanisms in the human amygdala that underlie post-traumatic stress disorder (PTSD) remain poorly understood. In a first-of-its-kind pilot study, we recorded intracranial electroencephalographic data longitudinally (over one year) in two male individuals with amygdala electrodes implanted for the management of treatment-resistant PTSD (TR-PTSD) under clinical trial NCT04152993. To determine electrophysiological signatures related to emotionally aversive and clinically relevant states (trial primary endpoint), we characterized neural activity during unpleasant portions of three separate paradigms (negative emotional image viewing, listening to recordings of participant-specific trauma-related memories, and at-home-periods of symptom exacerbation). We found selective increases in amygdala theta (5–9 Hz) bandpower across all three negative experiences. Subsequent use of elevations in low-frequency amygdala bandpower as a trigger for closed-loop neuromodulation led to significant reductions in TR-PTSD symptoms (trial secondary endpoint) following one year of treatment as well as reductions in aversive-related amygdala theta activity. Altogether, our findings provide early evidence that elevated amygdala theta activity across a range of negative-related behavioral states may be a promising target for future closed-loop neuromodulation therapies in PTSD.Item Open Access A wearable platform for closed-loop stimulation and recording of single-neuron and local field potential activity in freely moving humans(Nature Neuroscience) Topalovic, Uros; Barclay, Sam; Ling, Chenkai; Alzuhair, Ahmed; Yu, Wenhao; Hokhikyan, Vahagn; Chandrakumar, Hariprasad; Rozgic, Dejan; Jiang, Wenlong; Basir-Kazeruni, Sina; Maoz, Sabrina L; Inman, Cory S; Stangl, Matthias; Gill, Jay; Bari, Ausaf; Fallah, Aria; Eliashiv, Dawn; Pouratian, Nader; Fried, Itzhak; Suthana, Nanthia; Markovic, DejanAbstractAdvances in technologies that can record and stimulate deep brain activity in humans have led to impactful discoveries within the field of neuroscience and contributed to the development of novel therapies for neurological and psychiatric disorders. Further progress, however, has been hindered by device limitations in that recording of single-neuron activity during freely moving behaviors in humans has not been possible. Additionally, implantable neurostimulation devices, currently approved for human use, have limited stimulation programmability and restricted full-duplex bidirectional capability. In this study, we developed a wearable bidirectional closed-loop neuromodulation system (Neuro-stack) and used it to record single-neuron and local field potential activity during stationary and ambulatory behavior in humans. Together with a highly flexible and customizable stimulation capability, the Neuro-stack provides an opportunity to investigate the neurophysiological basis of disease, develop improved responsive neuromodulation therapies, explore brain function during naturalistic behaviors in humans and, consequently, bridge decades of neuroscientific findings across species.Item Open Access Boundary-anchored neural mechanisms of location-encoding for self and others(Nature, 2021-01-21) Stangl, Matthias; Topalovic, Uros; Inman, Cory S; Hiller, Sonja; Villaroman, Diane; Aghajan, Zahra M; Christov-Moore, Leonardo; Hasulak, Nicholas R; Rao, Vikram R; Halpern, Casey H; Eliashiv, Dawn; Fried, Itzhak; Suthana, NanthiaItem Open Access Dynamic neural representations of memory and space during human ambulatory navigation(Nature Communications) Maoz, Sabrina LL; Stangl, Matthias; Topalovic, Uros; Batista, Daniel; Hiller, Sonja; Aghajan, Zahra M; Knowlton, Barbara; Stern, John; Langevin, Jean-Philippe; Fried, Itzhak; Eliashiv, Dawn; Suthana, NanthiaAbstractOur ability to recall memories of personal experiences is an essential part of daily life. These episodic memories often involve movement through space and thus require continuous encoding of one’s position relative to the surrounding environment. The medial temporal lobe (MTL) is thought to be critically involved, based on studies in freely moving rodents and stationary humans. However, it remains unclear if and how the MTL represents both space and memory especially during physical navigation, given challenges associated with deep brain recordings in humans during movement. We recorded intracranial electroencephalographic (iEEG) activity while participants completed an ambulatory spatial memory task within an immersive virtual reality environment. MTL theta activity was modulated by successful memory retrieval or spatial positions within the environment, depending on dynamically changing behavioral goals. Altogether, these results demonstrate how human MTL oscillations can represent both memory and space in a temporally flexible manner during freely moving navigation.Item Open Access Mobile cognition: imaging the human brain in the ‘real world’(Nature Reviews Neuroscience, 2023-06) Stangl, Matthias; Maoz, Sabrina L; Suthana, NanthiaItem Open Access Proceedings of the Seventh Annual Deep Brain Stimulation Think Tank: Advances in Neurophysiology, Adaptive DBS, Virtual Reality, Neuroethics and Technology.(Frontiers in human neuroscience, 2020-01) Ramirez-Zamora, Adolfo; Giordano, James; Gunduz, Aysegul; Alcantara, Jose; Cagle, Jackson N; Cernera, Stephanie; Difuntorum, Parker; Eisinger, Robert S; Gomez, Julieth; Long, Sarah; Parks, Brandon; Wong, Joshua K; Chiu, Shannon; Patel, Bhavana; Grill, Warren M; Walker, Harrison C; Little, Simon J; Gilron, Ro'ee; Tinkhauser, Gerd; Thevathasan, Wesley; Sinclair, Nicholas C; Lozano, Andres M; Foltynie, Thomas; Fasano, Alfonso; Sheth, Sameer A; Scangos, Katherine; Sanger, Terence D; Miller, Jonathan; Brumback, Audrey C; Rajasethupathy, Priya; McIntyre, Cameron; Schlachter, Leslie; Suthana, Nanthia; Kubu, Cynthia; Sankary, Lauren R; Herrera-Ferrá, Karen; Goetz, Steven; Cheeran, Binith; Steinke, G Karl; Hess, Christopher; Almeida, Leonardo; Deeb, Wissam; Foote, Kelly D; Okun, Michael SThe Seventh Annual Deep Brain Stimulation (DBS) Think Tank held on September 8th of 2019 addressed the most current: (1) use and utility of complex neurophysiological signals for development of adaptive neurostimulation to improve clinical outcomes; (2) Advancements in recent neuromodulation techniques to treat neuropsychiatric disorders; (3) New developments in optogenetics and DBS; (4) The use of augmented Virtual reality (VR) and neuromodulation; (5) commercially available technologies; and (6) ethical issues arising in and from research and use of DBS. These advances serve as both "markers of progress" and challenges and opportunities for ongoing address, engagement, and deliberation as we move to improve the functional capabilities and translational value of DBS. It is in this light that these proceedings are presented to inform the field and initiate ongoing discourse. As consistent with the intent, and spirit of this, and prior DBS Think Tanks, the overarching goal is to continue to develop multidisciplinary collaborations to rapidly advance the field and ultimately improve patient outcomes.Item Open Access Promises and challenges of human computational ethology(Neuron, 2021-07) Mobbs, Dean; Wise, Toby; Suthana, Nanthia; Guzmán, Noah; Kriegeskorte, Nikolaus; Leibo, Joel ZItem Open Access Wireless Programmable Recording and Stimulation of Deep Brain Activity in Freely Moving Humans(Neuron, 2020-10) Topalovic, Uros; Aghajan, Zahra M; Villaroman, Diane; Hiller, Sonja; Christov-Moore, Leonardo; Wishard, Tyler J; Stangl, Matthias; Hasulak, Nicholas R; Inman, Cory S; Fields, Tony A; Rao, Vikram R; Eliashiv, Dawn; Fried, Itzhak; Suthana, Nanthia