Browsing by Author "Wilson, EA"

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Open Access
Introduction: Antinormativity's Queer Conventions
(differences, 2015-01-26) Wiegman, R; Wilson, EA
Can queer theory proceed without an allegiance to antinormativity? The introduction to this special issue establishes the value of this question by staging an encounter with the most widely held assumption in queer theory today: that the political value of the field lies in its antinormative commitments. The first section of this introduction demonstrates how profoundly the history of queer theorizing has been shaped by an antinormative sensibility, one that has organized the multiple and at times discordant itineraries of analysis that comprise the queer theoretical archive into a field-forming synthesis. In part 2, the authors offer a more studied consideration of the character of norms. By articulating the difference between a norm and the terms that often define it—domination, homogenization, exclusion, hegemony, identity, or more colloquially, the familiar, status quo, or routine—this section demonstrates the importance of renewing queer theoretical attention to the conceptual and political particularity of normativity as a distinct object of inquiry. The authors’ aim is not to dismiss the political agenda that antinormativity has come to represent for queer inquiry, but to channel some of the field’s energies toward analyzing the critical authority it now wields. This entails promoting scholarship that not only rethinks the meaning of norms, normalization, and the normal but that also imagines new ways to approach the politics of queer criticism altogether. In the final section, the authors describe the specific contribution of each of the volume’s essays to this endeavor.
Open Access
Poor Positive Predictive Value of Lyme Disease Serologic Testing in an Area of Low Disease Incidence.
(Clin Infect Dis, 2015-11-01) Lantos, PM; Branda, JA; Boggan, JC; Chudgar, SM; Wilson, EA; Ruffin, F; Fowler, VG; Auwaerter, PG; Nigrovic, LE
BACKGROUND: Lyme disease is diagnosed by 2-tiered serologic testing in patients with a compatible clinical illness, but the significance of positive test results in low-prevalence regions has not been investigated. METHODS: We reviewed the medical records of patients who tested positive for Lyme disease with standardized 2-tiered serologic testing between 2005 and 2010 at a single hospital system in a region with little endemic Lyme disease. Based on clinical findings, we calculated the positive predictive value of Lyme disease serology. Next, we reviewed the outcome of serologic testing in patients with select clinical syndromes compatible with disseminated Lyme disease (arthritis, cranial neuropathy, or meningitis). RESULTS: During the 6-year study period 4723 patients were tested for Lyme disease, but only 76 (1.6%) had positive results by established laboratory criteria. Among 70 seropositive patients whose medical records were available for review, 12 (17%; 95% confidence interval, 9%-28%) were found to have Lyme disease (6 with documented travel to endemic regions). During the same time period, 297 patients with a clinical illness compatible with disseminated Lyme disease underwent 2-tiered serologic testing. Six of them (2%; 95% confidence interval, 0.7%-4.3%) were seropositive, 3 with documented travel and 1 who had an alternative diagnosis that explained the clinical findings. CONCLUSIONS: In this low-prevalence cohort, fewer than 20% of positive Lyme disease tests are obtained from patients with clinically likely Lyme disease. Positive Lyme disease test results may have little diagnostic value in this setting.