Browsing by Author "Wu, Xueling"

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    Two distinct broadly neutralizing antibody specificities of different clonal lineages in a single HIV-1-infected donor: implications for vaccine design.
    (J Virol, 2012-04) Bonsignori, Mattia; Montefiori, David C; Wu, Xueling; Chen, Xi; Hwang, Kwan-Ki; Tsao, Chun-Yen; Kozink, Daniel M; Parks, Robert J; Tomaras, Georgia D; Crump, John A; Kapiga, Saidi H; Sam, Noel E; Kwong, Peter D; Kepler, Thomas B; Liao, Hua-Xin; Mascola, John R; Haynes, Barton F
    Plasma from a small subset of subjects chronically infected with HIV-1 shows remarkable magnitude and breadth of neutralizing activity. From one of these individuals (CH0219), we isolated two broadly neutralizing antibodies (bnAbs), CH01 and VRC-CH31, from two clonal lineages of memory B cells with distinct specificities (variable loop 1 and 2 [V1V2] conformational specificity and CD4-binding site specificity, respectively) that recapitulate 95% of CH0219 serum neutralization breadth. These data provide proof of concept for an HIV-1 vaccine that aims to elicit bnAbs of multiple specificities.