Browsing by Author "Yamey, Gavin"
Results Per Page
Sort Options
Item Open Access A Cost-Effectiveness Analysis of Timely Otitis Media Treatment through a Community Health Worker Delivered School Screening Program(2023-04-19) Johri, MohiniIn certain settings, otitis-media related hearing loss forms a large proportion of total hearing loss cases. Delays to timely otitis media diagnosis and appropriate treatment leads to more serious otitis media cases, sometimes chronic suppurative otitis media, which may lead to a permanent hearing loss. A primary driver in the delay to diagnosis and treatment is a lack of easily accessed, trained healthcare workers in the identification and treatment of otitis media. We used an exemplar setting, Zambia, to understand the costs and potential effects of community health worker-delivered screening program for school-age children. The goal of this analysis was to highlight otitis media as a driver of hearing loss and understand the cost-effectiveness of timely diagnosis/treatment to prevent downstream hearing loss. The treatment pathway for otitis media treatment was identified using a cascade of care framework, as well as the effects of increased otitis media treatment access though stakeholder engagement metrics. The treatment for otitis media in this analysis was conservative treatment, aural toileting and topical antibiotics. Additionally, the costs of otitis media and chronic suppurative otitis media and the proportion of both metrics treated in Nigeria were found. Training costs of a program were included in the treatment pathway to adequately model the scale-up strategy. Simulated persons experience yearly age- and sex- specific probabilities of acquiring hearing loss, the prevalence of which is 3.6% in Nigeria. The population of interest was six-year-old children in Nigeria suffering from otitis media across their lifetime. Strategies for comparison to increase appropriate treatment of otitis media included current care and the implementation of a community health worker-delivered screening program. Main measures included lifetime undiscounted and discounted (3%/year) costs and QALYs and incremental cost-effectiveness ratios (ICERs) by Nigerian standard (<3x $2,097.09 was considered cost-effective). Current detection (CD) resulted in 19.22 discounted average person-years of otitis media treatment compared to 19.23 discounted average person-years with implementation of a CHW delivered screening program. Lifetime total per-person undiscounted costs were $64.26 USD for CD and $62.26 USD with the screening program intervention, indicating that the screen is both less costly and more effective than not screening. Results were most sensitive to variations in cost of screen, cost of CSOM, rAOM, pOME resolution from screening, and CI device cost. Limitations included input uncertainty given limited data sources for similar settings. Additionally, we had to use a utility decrement for moderate hearing loss since there is not one in the model that we identified specifically for CSOM. We project that a community health worker delivered screening program is cost-effective by US standards. Further research is needed to determine whether screening at younger ages or different treatments for otitis media is cost-effective.Item Open Access Association Between Major Non-communicable Diseases, Healthcare Use, Financial Burden and Socioeconomic Factors in China: A Cross-Sectional Study(2021) Zhang, XinqiBackground Four major noncommunicable diseases (NCDs)—cardiovascular diseases (CVD), diabetes, chronic respiratory diseases, and cancer—have become the leading causes of disability-adjusted life-years in China. Curbing these diseases is critical in the Healthy China 2030 plan, a national health promotion strategy. A key question is whether the plan will expand service capacity for people with NCDs, and also reduce the financial burden that people in China suffer in paying for those services. In order to inform this question, this study examined (i) the current use of healthcare services in China by people with different types of NCDs; (ii) the financial burden they experience in seeking such care; and (iii) whether socioeconomic status (SES) factors influence both their use of healthcare services and the financial burden of service use.Method We used data from the 2018 wave of a nationally representative survey, called China Health and Retirement Longitudinal Study (CHARLS). We included all participants who were interviewed in the 2018 survey. We examined three types of outcomes: perceived healthcare needs (measured by self-reported health), the use of healthcare services, and the financial burden of such use (as assessed by out-of-pocket expenses [OOP] and catastrophic health expenditure [CHE]). The indicators we used were four major NCDs, and SES factors (including education status, employment status, income level, residence status, and different health insurance schemes: Urban Employee Basic Medical Insurance [UEBMI], and Urban-Rural Resident Medical Insurance [URRMI]). Logistic regression models were used to assess effects of having four NCDs and SES factors on people’s perceived needs, healthcare service use, and CHE. Negative binomial models were performed to assess the effects of four major NCDs and SES factors on the number of times that healthcare services were used. Multiple linear regression models were adopted to examine the associations between four major NCDs, SES factors, the financial burden of service use, and the distance from the healthcare facility to home. Results A total of 20,813 respondents were included in our analyses. Compared with having one or more of the four major NCDs, there is some evidence that having no NCDs was associated with lower odds of having an outpatient visit in the last month (odds ratio [OR]=0.86), a hospitalization in the last year (OR=0.87) or taking purchased medicine in the last month (OR=0.82). People without NCDs may also have lower OOP for purchasing medicines in the last month compared with those with one or more of the four major NCDs (exponentiated β = 0.87). However, no evidence of differences was found in healthcare service use and the financial burden of the service use between people with four major NCDs and people with other types of NCDs. In relation to SES factors, (i) residency status: people living in rural areas may have higher baseline odds (OR = 1.11) of taking self-purchased medicine, more hospital admissions during the past year (IRR = 1.25), longer distance traveled from home to their last outpatient visit (exponentiated β = 1.28), and longer distance traveled from home to their last inpatient visit facility (exponentiated β = 1.25) than those who were in urban areas. (ii) health insurance type: some evidence showed that people without health insurance may have worse self-perceived health (OR = 1.53), lower odds of going to an outpatient visit in the last month (OR=0.71), and lower odds of an inpatient visit in the last year (OR=0.32) compared with people covered by UEBMI. People without health insurance also may travel further from home to an inpatient facility (exponentiated β = 3.39) and have higher odds of experiencing CHE (OR = 1.37) compared with people with UEBMI. People covered with URRMI may have poorer self-perceived health (OR = 1.21), lower odds of having an inpatient visit in the last year (OR=0.73), lower number of hospital admissions in the last year (IRR = 0.77) and lower OOP expenses for the last outpatient visit (exponentiated β = 0.77) than people with UEBMI. They also may travel longer distances from their home to an inpatient facility (exponentiated β = 2.06) than people with UEBMI. Conclusion There was no evidence showed that there were differences between having one or more of these four major NCDs versus having other types of NCDs in people’s self-perceived health, their use of healthcare services, and the financial burden of such service use, thus we should not overlook the prevention and management of other types of NCDs. In addition, continuous attention should be paid to the prevention and management of four major NCDs in China. Despite the Chinese government’s efforts to improve the health system to ensure universal health coverage in China, efforts should be further taken in providing financial protection to people in less-resourced settings (i.e., people living in rural areas and those without a health insurance plan) and to avoid inequality in healthcare service use that favors richer people.
Item Open Access Facilitators and Barriers to the Advancement of Oral Health on the Global Health Agenda: A Qualitative Study with Key Oral Health Stakeholders(2022) Byott, Yasmin RauzDental caries accounts for the primary burden of disease globally,1 a burden which falls heavily on those least able to access treatment.2 Despite this burden, oral health remains neglected on the global agenda. Thus, we sought to conduct a qualitative study to determine why oral health occupies the position it does on the global agenda as well as what factors might promote or prevent its ascent. Virtual interviews were conducted with key oral health stakeholders identified by the Lancet Commission on Oral Health and coded to reveal underlying themes. Our study found several reasons for the neglect of oral health by global health policymakers. These include the separation of oral health care from comprehensive health care; the lack of research and data on oral health; competing interests from multinational food companies that promote and sell sugary foods and beverages; and the dental profession’s propensity for treatment over prevention. Integration of oral health into UHC schemes, expanded research and data collection, sugar taxation, and task-shifting were identified as potential avenues to facilitate oral health’s prioritization on the global agenda.
Item Open Access Financial contributions to global surgery: an analysis of 160 international charitable organizations.(SpringerPlus, 2016-01) Gutnik, Lily; Yamey, Gavin; Riviello, Robert; Meara, John G; Dare, Anna J; Shrime, Mark GThe non-profit and volunteer sector has made notable contributions to delivering surgical services in low-and middle-income countries (LMICs). As an estimated 55 % of surgical care delivered in some LMICs is via charitable organizations; the financial contributions of this sector provides valuable insight into understanding financing priorities in global surgery.Databases of registered charitable organizations in five high-income nations (United States, United Kingdom, Canada, Australia, and New Zealand) were searched to identify organizations committed exclusively to surgery in LMICs and their financial data. For each organization, we categorized the surgical specialty and calculated revenues and expenditures. All foreign currency was converted to U.S. dollars based on historical yearly average conversion rates. All dollars were adjusted for inflation by converting to 2014 U.S. dollars.One hundred sixty organizations representing 15 specialties were identified. Adjusting for inflation, in 2014 U.S. dollars (US$), total aggregated revenue over the years 2008-2013 was $3·4 billion and total aggregated expenses were $3·1 billion. Twenty-eight ophthalmology organizations accounted for 45 % of revenue and 49 % of expenses. Fifteen cleft lip/palate organizations totaled 26 % of both revenue and expenses. The remaining 117 organizations, representing a variety of specialties, accounted for 29 % of revenue and 25 % of expenses. In comparison, from 2008 to 2013, charitable organizations provided nearly $27 billion for global health, meaning an estimated 11.5 % went towards surgery.Charitable organizations that exclusively provide surgery in LMICs primarily focus on elective surgeries, which cover many subspecialties, and often fill deep gaps in care. The largest funding flows are directed at ophthalmology, followed by cleft lip and palate surgery. Despite the number of contributing organizations, there is a clear need for improvement and increased transparency in tracking of funds to global surgery via charitable organizations.Item Open Access Funding allocation to surgery in low and middle-income countries: a retrospective analysis of contributions from the USA.(BMJ open, 2015-11-09) Gutnik, Lily; Dieleman, Joseph; Dare, Anna J; Ramos, Margarita S; Riviello, Robert; Meara, John G; Yamey, Gavin; Shrime, Mark GOBJECTIVE:The funds available for global surgical delivery, capacity building and research are unknown and presumed to be low. Meanwhile, conditions amenable to surgery are estimated to account for nearly 30% of the global burden of disease. We describe funds given to these efforts from the USA, the world's largest donor nation. DESIGN:Retrospective database review. US Agency for International Development (USAID), National Institute of Health (NIH), Foundation Center and registered US charitable organisations were searched for financial data on any organisation giving exclusively to surgical care in low and middle income countries (LMICs). For USAID, NIH and Foundation Center all available data for all years were included. The five recent years of financial data per charitable organisation were included. All nominal dollars were adjusted for inflation by converting to 2014 US dollars. SETTING:USA. PARTICIPANTS:USAID, NIH, Foundation Center, Charitable Organisations. PRIMARY AND SECONDARY OUTCOME MEASURES:Cumulative funds appropriated to global surgery. RESULTS:22 NIH funded projects (totalling $31.3 million) were identified, primarily related to injury and trauma. Six relevant USAID projects were identified-all obstetric fistula care totalling $438 million. A total of $105 million was given to universities and charitable organisations by US foundations for 12 different surgical specialties. 95 US charitable organisations representing 14 specialties totalled revenue of $2.67 billion and expenditure of $2.5 billion. CONCLUSIONS AND RELEVANCE:Current funding flows to surgical care in LMICs are poorly understood. US funding predominantly comes from private charitable organisations, is often narrowly focused and does not always reflect local needs or support capacity building. Improving surgical care, and embedding it within national health systems in LMICs, will likely require greater financial investment. Tracking funds targeting surgery helps to quantify and clarify current investments and funding gaps, ensures resources materialise from promises and promotes transparency within global health financing.Item Open Access Ghana’s Impending Loss of Foreign Aid for HIV/AIDS Programs: Effects on Vulnerable Populations(2020) Riviere, JudyAs countries transition from low income to middle income countries, they gradually lose donor aid. Donor aid for HIV in Ghana is slowly declining and more commitment from the government is expected for funding HIV/AIDS programs. Vulnerable populations are disproportionally affected by HIV and might be at greater risk as donors exit Ghana. This research used semi-structured interviews with 26 key informants to understand how vulnerable populations could be affected by the transition away from donor aid for HIV. This study found that vulnerable populations in Ghana mostly receive support from civil society organizations (CSOs) that are funded by donors. As funding transitions to government, CSOs are likely to reduce the scope of their work, and populations will lose access to some key preventative activities. In addition, HIV programs will be focused on the general population as opposed to the most vulnerable. Finally, if the transition is managed properly, involving key stakeholders at early stages of the process and ensuring partnerships between government and CSOs, it could in fact empower vulnerable populations to have increased decision-making power.
Item Open Access Global Equity Challenges in COVID-19 Vaccine Purchasing(2021-04-21) Raj, AneeshaA rush to preemptively secure COVID-19 vaccines resulted in high income countries hoarding an excess supply while low- and middle-income countries are prevented from equitable access. Previous work on equity in vaccine purchasing has compared cases per million of COVID-19 to vaccination coverage but does not reflect urgent pressures placed on healthcare systems. This analysis investigates vaccination coverage against three measures of COVID-19 burden: deaths per 100,000 population, general hospital capacity reached, and ICU capacity reached, in order to identify the countries overburdened and underrepresented in vaccine purchasing. Publicly available data from the Duke Launch & Scale Speedometer, IHME COVID-19 projections, and Johns Hopkins COVID-19 mortality reports are used for this analysis. While non-high-income countries comprised 64% of this dataset, they represented 93% of countries in ICU crisis, 87% in general hospital capacity crisis, and 85% in a mortality crisis. This data provides evidence for the creation of a priority list for equitable global allocation of vaccines to low- and middle-income countries. High income countries can be incentivized to redistribute their excess vaccine supplies by reframing measures of pandemic progress away from nationalistic targets.Item Open Access How are health policy makers managing donor exits: a policy analysis of Ghana’s transition from the United States President’s Emergency Plan for AIDS Relief (PEPFAR)(2020) Zhang, JiaqiBackground: When Ghana undergoes economic growth, and becomes a middle-income country, it will face the loss of official development assistance (ODA), including ODA for health. PEPFAR has been supporting Ghana for many years and now is reducing its funding in Ghana.
Methods: This is a qualitative study based on 21 in-depth, key informant interviews conducted between May and October 2019. Study participants were individuals who are involved in Ghana’s national HIV/AIDS response; they included government officials, technical officers from international organizations, staff from donor agencies, and staff from local civil society organizations (CSOs).
Results: PEPFAR has been playing a significant role for Ghana’s national HIV/AIDS control. However, it is reducing its funding in Ghana because of Ghana’s poor performance and government commitment. PEPFAR is transiting its work focus to only the Western Region in order to achieve epidemic control in this region. This transition will bring many challenges to Ghana such as financial, governance, and system challenges. The government of Ghana and CSOs in Ghana have been aware of PEPFAR’s transition for some time, and initial plans are conducted to manage this transition. At the same time, PEPFAR is trying to initiate conversations with other donors to fill in the potential gaps.
Conclusions: Transition is shared responsibility. PEPFAR as a donor could publish its specific transition plan for Ghana to navigate this transition. Ghana as a recipient country could make more commitment to perform better with donor findings. Donors will not provide permanent assistance; transition is a good chance for country to stand fully on its own feet. Mobilizing domestic resources is important to sustain Ghana as a country itself and manage the transition.
Item Open Access Impact of COVID-19 on maternal and child health services: A qualitative study of donors' perspectives(2021) Farooqi, Zoha WaqarBackground: Previous pandemics have shown that disruption of essential services could undo decades of efforts to reduce maternal and child mortality. Therefore, preventing disruption of essential services such as immunizations, skilled birth delivery, antenatal care etc. and safeguarding adequate sources of maternal and child health funding should be a key priority for governments and health donors. This study will aim to understand the impact of COVID-19 on maternal and child health services and how donors and policymakers are determining financing and policy priorities amid the COVID-19 pandemic. Methods: A qualitative study was conducted with thirteen health experts from key bilateral and multilateral organizations and international NGOs. In addition to these interviews, relevant publications such as donor policies on their responses to COVID-19 were also reviewed and synthesized. Key informants provided written consent and all interviews were audio-recorded. Results: Governments across the world should increase their efforts to sustain essential health services for mothers and children. In addition, donors must provide greater support for weak health systems by granting extensions in loan repayments and providing technical assistance and essential supplies for health workers. Use of digital technologies, collaborative information sharing processes and flexibility in funding streams have been considered the best form of support that donors can provide. Conclusion: This study contributes to understanding the key role played by contemporary global health actors involved in formulating the initial policy responses and guidelines for countries during the COVID-19 pandemic on continuation of essential services such as maternal and child health. The findings can help understand the preliminary steps taken by the donor community to respond to the pandemic and can lay the groundwork to determine the future direction of financing and key health priority areas.
Item Open Access Life and Liberty: Economic, Political and Ethical Issues Arising from 21st Century Quarantines for Influenza(2017-04-24) Serat, SimoneQuarantine is a word that elicits fear among many. However, it is also a long-utilized and important policy tool for controlling the spread of infectious diseases. This thesis considers the role of quarantine for influenza outbreaks during the twenty-first century. I thematically review scientific literature on the ethical, social and political, and economic issues that have arisen from or have the potential to arise from quarantines for influenza. After identifying these issues, I make policy recommendations targeted at mitigating them. I then compare these with the World Health Organization’s (WHO) Influenza Preparedness and Response Guidance to determine where our recommendations overlap and diverge. I propose a set of five additional recommendations to the WHO Guidance for governments considering implementing quarantines for influenza: develop of a body of experts and stakeholders for policymaking, use least-restrictive policy measures first, establish a duty to treat and its limits, determine who will be prioritized during cases of scarcity, and establish support and compensation mechanisms for quarantined individuals. My research contributes to the discourse around quarantine for influenza by identifying a broad scope of consequences of quarantine for influenza. It also contributes to the existing literature on quarantine design for influenza by proposing policies targeted at addressing the issues I identify. While this research is a start, there is still a great need for further research to prepare for and learn from influenza outbreaks. My recommendations fit well alongside existing influenza pandemic preparedness plans such as the WHO’s Pandemic Influenza Preparedness and Response Guidance during an influenza outbreak to develop robust disease control policy for influenza outbreaks.Item Open Access Needs and Experiences of Latinx Migrant and Seasonal Farmworkers Before, During, and After Natural Disasters in Rural North Carolina(2018-12) Nagler, EmilyDue to structural factors, migrant and seasonal farmworkers (MSFWs) in the United States experience heightened challenges surviving and recovering from natural disasters, which negatively impact public health. Climate change models predict North Carolina (NC) will face an increased frequency and intensity of natural disasters in the near future, making disaster preparedness for MSFWs an urgent issue. This study sought to answer: how do Latinx MSFWs in rural NC experience natural disasters and how can policies and programs better serve the unique needs of this population in emergency situations? This study used qualitative descriptive methods and key informant interviews with service providers and Latinx MSFWs. It used emergent theme analysis (coding with NVivo). Key informants reported that MSFWs are economically important to their communities, though also very marginalized. They face various barriers to preparing for natural disasters: economic constraints, low English proficiency, potential distrust of government institutions or fear of law enforcement, and geographic isolation. After Hurricane Matthew, which caused severe damages to NC’s rural counties in 2016, many MSFWs were left stranded in flooded trailers, exposing them to lasting mental and physical health risks. Flooding prevented most MSFWs from working for up to several weeks, which impacted their families financially. This study contributed to the literature by including both MSFW and service provider perspectives. Future studies should examine ways to (a) improve MSFWs’ access to preparedness information and emergency alerts, (b) help emergency services departments provide resources to MSFWs, and (c) better understand the impacts of natural disasters on MSFWs’ physical and mental health. Though local governments in rural NC are aware of their shortcomings in working with diverse communities, they will need further resources to improve their relationships with Latinx MSFW communities.Item Open Access Preparing for the Next Pandemic: Exploring the Design of a New Pandemic Vaccine Facility (“PANVAX”) Through a Qualitative Study(2022) Murphy, RonanThe global distribution of COVID-19 vaccines has been inequitable: around 8 in 10 people in high-income countries have had at least one dose, compared with just 1 in 10 in low-income countries. Similar global vaccine inequity was seen in past pandemics, such as the 2009 H1N1 pandemic. The COVID-19 Vaccine Global Access Facility (COVAX), launched by the Coalition for Epidemic Preparedness (CEPI), Gavi, the Vaccine Alliance (Gavi), and the World Health Organization (WHO), aimed to equitably distribute vaccines worldwide. COVAX was an unprecedented mechanism—the first attempt to create a pandemic vaccine buyers’ club for all nations of all income levels. COVAX can serve as a case study: by determining what challenges and successes it has had during COVID-19, we can determine what elements a future pandemic vaccine facility (which we can call “PANVAX”) may need to ensure equity in the next pandemic. In this qualitative study, 14 in-depth interviews were conducted across 4 different stakeholder groups to elicit expert opinions on COVAX and on the design of a future PANVAX. These four stakeholder groups were pharmaceutical company representatives, COVAX administrators, academics, and national governments. Key informants argued that the concept of COVAX was strong and COVAX succeeded in securing participation from pharmaceutical companies, but it suffered from many challenges, including vaccine supply shortages and delays, challenges in negotiating with vaccine companies, internal governance challenges, and a lack of participation by high-income countries in the buyers’ club. They also suggested that in a future pandemic vaccine facility, there needs to be upfront funding, investment into the entire vaccine development process, regional vaccine capacity building, and a ‘day-job’ for the facility when there is no pandemic to keep the facility running. Overall, this study found that COVAX was faced by challenges that were both of its own making and outside of its control. For future pandemics, there is a clear need for a facility that has sufficient upfront funding for purchasing and investing into all aspects of the vaccine process, and that has responsibilities outside of pandemic or emergency response. By focusing on regional vaccine self-sufficiency, several issues can be addressed both for pandemic response and public health benefits.
Item Open Access Strategic donor behaviour and country vulnerability in health aid transitions.(BMJ global health, 2023-11) Mao, Wenhui; McDade, Kaci Kennedy; Ogbuoji, Osondu; Yamey, Gavin; Bermeo, Sarah BlodgettBackground
When countries reach the middle-income threshold, many multilateral donors, including Gavi, the Vaccine Alliance (Gavi), begin to withdraw their official development assistance (ODA), known as graduation. We hypothesised that bilateral donors might follow Gavi's lead, except in countries where they have strategic interests. We aim to understand how bilateral donors behave after a recipient country graduates from Gavi support and how bilateral donors might treat Gavi support countries differently, based on 'strategic interest'. We also aim to identify countries that were more vulnerable to 'simultaneous' transitions and financial cliffs after Gavi transition.Methods
This is an observational dyadic analysis using longitudinal data. We collected country-level data on 77 Gavi-eligible countries between 2009 and 2018 and paired donor and recipient country in a specific year to conduct dyadic analysis. We included Gavi graduation status and Gavi disbursement as explanatory variables. We controlled for (1) donor-recipient relationship variables that represent potential strategic relationships (eg, distance between donor and recipient country) and (2) recipient-level characteristics (eg, population, income). We used Odinary Least Squares regression, Tobit and two-part model in Stata SE 15.0.Findings
We found a country would receive $3.1 million less all sector ODA from a bilateral donor, and $0.6 million less health ODA, after they graduate from Gavi. For every additional 1% ODA a country would receive from Gavi, it would receive 0.14% more ODA and 0.16% more health ODA from individual bilateral donors. Gavi's graduation status or disbursement brought more change in percentage term to health ODA than to total ODA. Additionally, Gavi's graduation was observed to have a larger negative impact on bilateral ODA in the longer term. Countries that sent more migrants, had been colonised, and received more US military assistance tended to receive more ODA. There are similarities and differences across different donors and bilateral donors tend to provide more ODA to nearby countries and countries receiving fewer exports from the donor. We found that former colonies did not see a decline in aid after Gavi graduation.Conclusion
Bilateral donors behave in a similar manner to Gavi when it comes to funding health systems in low and middle-income countries. Therefore, some countries may be at risk of losing donor resources for health from a multitude of sources around the same time. However, countries that have a strategic interest in bilateral donors may be spared from such funding cliffs. This research has important implications for global health donors' funding policies and approaches in addition to recipient countries' transition planning.