Browsing by Author "Yang, Fan"
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Item Open Access A necessary and sufficient condition for edge universality at the largest singular values of covariance matrices(The Annals of Applied Probability, 2018-06) Ding, Xiucai; Yang, FanItem Open Access BTLA+CD200+ B cells dictate the divergent immune landscape and immunotherapeutic resistance in metastatic vs. primary pancreatic cancer(Oncogene, 2022-09-16) Diskin, Brian; Adam, Salma; Soto, Gustavo Sanchez; Liria, Miguel; Aykut, Berk; Sundberg, Belen; Li, Eric; Leinwand, Joshua; Chen, Ruonan; Kim, Mirhee; Salas, Ruben D; Cassini, Marcelo F; Buttar, Chandan; Wang, Wei; Farooq, Mohammad Saad; Shadaloey, Sorin AA; Werba, Gregor; Fnu, Amreek; Yang, Fan; Hirsch, Carolina; Glinski, John; Panjwani, Angilee; Weitzner, Yael; Cohen, Deirdre; Asghar, Usman; Miller, GeorgeItem Open Access Chondrogenesis and mineralization during in vitro culture of human mesenchymal stem cells on three-dimensional woven scaffolds.(Tissue Eng Part A, 2010-12) Abrahamsson, Christoffer K; Yang, Fan; Park, Hyoungshin; Brunger, Jonathan M; Valonen, Piia K; Langer, Robert; Welter, Jean F; Caplan, Arnold I; Guilak, Farshid; Freed, Lisa EHuman mesenchymal stem cells (hMSCs) and three-dimensional (3D) woven poly(ɛ-caprolactone) (PCL) scaffolds are promising tools for skeletal tissue engineering. We hypothesized that in vitro culture duration and medium additives can individually and interactively influence the structure, composition, mechanical, and molecular properties of engineered tissues based on hMSCs and 3D poly(ɛ-caprolactone). Bone marrow hMSCs were suspended in collagen gel, seeded on scaffolds, and cultured for 1, 21, or 45 days under chondrogenic and/or osteogenic conditions. Structure, composition, biomechanics, and gene expression were analyzed. In chondrogenic medium, cartilaginous tissue formed by day 21, and hypertrophic mineralization was observed in the newly formed extracellular matrix at the interface with underlying scaffold by day 45. Glycosaminoglycan, hydroxyproline, and calcium contents, and alkaline phosphatase activity depended on culture duration and medium additives, with significant interactive effects (all p < 0.0001). The 45-day constructs exhibited mechanical properties on the order of magnitude of native articular cartilage (aggregate, Young's, and shear moduli of 0.15, 0.12, and 0.033 MPa, respectively). Gene expression was characteristic of chondrogenesis and endochondral bone formation, with sequential regulation of Sox-9, collagen type II, aggrecan, core binding factor alpha 1 (Cbfα1)/Runx2, bone sialoprotein, bone morphogenetic protein-2, and osteocalcin. In contrast, osteogenic medium produced limited osteogenesis. Long-term culture of hMSC on 3D scaffolds resulted in chondrogenesis and regional mineralization at the interface between soft, newly formed engineered cartilage, and stiffer underlying scaffold. These findings merit consideration when developing grafts for osteochondral defect repair.Item Open Access Health Beliefs and Contraception Use in Leogane, Haiti: A Qualitative Study(2013) Yang, FanUncontrolled birth spacing is associated with higher rates of maternal and neonatal morbidity and mortality in low resource countries. The use of modern contraception (MC) is a strategy that proven to be successful to control birth spacing in the United States but is frequently unsuccessful in Haiti.
This study is intended to investigate women's health beliefs about MC in Leogane, Haiti. The Extended Health Belief Model from behavioral science is employed as a framework for data collection on three domains: perceived threats of unintended pregnancy, perceived barriers of contraception use, and modifying factors. In depth interviews of 16 reproductive age women conducted from June to July 2012 were transcribed and translated for analysis in QSR Nvivo. Seven themes are identified from the conversations. The results demonstrated that all the 16 women interviewed perceive unintended pregnancy as a threat that may potentially affecting women's life. Their perceptions of barriers during MC seeking include the fear of side effects and financial unaffordability. Modifying factors influencing their contraception use consist of competing traditional contraception methods, peer advice/experience, and religion. These findings suggest that future health education program should focus on contraception side effects knowledge spreading and replacing traditional methods with modern contraception through peer education and unmet family planning needs will be accommodated in Leogane, Haiti.
Item Open Access Intrahepatic microbes govern liver immunity by programming NKT cells(Journal of Clinical Investigation, 2022-04-15) Leinwand, Joshua C; Paul, Bidisha; Chen, Ruonan; Xu, Fangxi; Sierra, Maria A; Paluru, Madan M; Nanduri, Sumant; Alcantara, Carolina G; Shadaloey, Sorin AA; Yang, Fan; Adam, Salma A; Li, Qianhao; Bandel, Michelle; Gakhal, Inderdeep; Appiah, Lara; Guo, Yuqi; Vardhan, Mridula; Flaminio, Zia; Grodman, Emilie R; Mermelstein, Ari; Wang, Wei; Diskin, Brian; Aykut, Berk; Khan, Mohammad; Werba, Gregor; Pushalkar, Smruti; McKinstry, Mia; Kluger, Zachary; Park, Jaimie J; Hsieh, Brandon; Dancel-Manning, Kristen; Liang, Feng-Xia; Park, James S; Saxena, Anjana; Li, Xin; Theise, Neil D; Saxena, Deepak; Miller, George