Browsing by Author "Yashin, Anatoli"

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Open Access
Assessing tilavonemab efficacy in early Alzheimer's disease via longitudinal item response theory modeling
(Alzheimer's & Dementia: Translational Research & Clinical Interventions, 2024-04) Zhou, Xiaoxiao; Zou, Haotian; Lutz, Michael W; Arbeev, Konstantin; Akushevich, Igor; Yashin, Anatoli; Welsh-Bohmer, Kathleen A; Luo, Sheng
AbstractINTRODUCTIONAlzheimer's disease (AD) is a neurodegenerative disorder characterized by declines in cognitive and functional severities. This research utilized the Clinical Dementia Rating (CDR) to assess the influence of tilavonemab on these deteriorations.METHODSLongitudinal Item Response Theory (IRT) models were employed to analyze CDR domains in early‐stage AD patients. Both unidimensional and multidimensional models were contrasted to elucidate the trajectories of cognitive and functional severities.RESULTSWe observed significant temporal increases in both cognitive and functional severities, with the cognitive severity deteriorating at a quicker rate. Tilavonemab did not demonstrate a statistically significant effect on the progression in either severity. Furthermore, a significant positive association was identified between the baselines and progression rates of both severities.DISCUSSIONWhile tilavonemab failed to mitigate impairment progression, our multidimensional IRT analysis illuminated the interconnected progression of cognitive and functional declines in AD, suggesting a comprehensive perspective on disease trajectories.Highlights Utilized longitudinal Item Response Theory (IRT) models to analyze the Clinical Dementia Rating (CDR) domains in early‐stage Alzheimer's disease (AD) patients, comparing unidimensional and multidimensional models. Observed significant temporal increases in both cognitive and functional severities, with cognitive severity deteriorating at a faster rate, while tilavonemab showed no statistically significant effect on either domain's progression. Found a significant positive association between the baseline severities and their progression rates, indicating interconnected progression patterns of cognitive and functional declines in AD. Introduced the application of multidimensional longitudinal IRT models to provide a comprehensive perspective on the trajectories of cognitive and functional severities in early AD, suggesting new avenues for future research including the inclusion of time‐dependent random effects and data‐driven IRT models.
Open Access
Increase in circulating levels of IGF-1 and IGF-1/IGFBP-3 molar ratio over a decade is associated with colorectal adenomatous polyps.
(Int J Cancer, 2012-07-15) Soubry, Adelheid; Il'yasova, Dora; Sedjo, Rebecca; Wang, Frances; Byers, Tim; Rosen, Clifford; Yashin, Anatoli; Ukraintseva, Svetlana; Haffner, Steven; D'Agostino, Ralph
High levels of circulating insulin-like growth factor-1 (IGF-1) have been associated with increased risk of several cancers. Regarding colorectal cancer, these associations are generally weak. We hypothesized that an increase in IGF-1 over time would be a stronger risk factor for cancer-related outcomes than the actual levels. In this analysis we utilized existing data from the Insulin Resistance and Atherosclerosis Study (IRAS). Circulating IGF-1 levels and molar ratios of IGF-1 to IGF binding protein 3 (IGFBP-3) were measured at three time points, within a 10-year follow-up period. We examined the associations of increase of the two variables with the presence of colorectal adenoma at the end of follow-up among participants with normal glucose tolerance at baseline. This included 143 individuals, from which 24 were diagnosed with adenomatous polyps. Although the mean levels of IGF-1 and IGF-1/IGFBP-3 decline with age, ~ 30% of the participants showed an increase of at least fifteen percent ("ever increase") in one or both of these variables, compared to baseline. We found a positive association between "ever increase" in IGF-1 or IGF-1/IGFBP-3 and the presence of colorectal adenoma: ORs were 3.81 (95% CI: 1.30-10.8) and 2.83 (95% CI: 1.00-8.22), respectively. No association was found when analyzing the actual levels of both variables at any time point. Our data suggest that an increase in circulating IGF-1 or IGF-1/IGFBP-3 may represent a disturbed GH/IGF1 homeostasis, which could favor the development of precancerous lesions such as colorectal adenoma.
Open Access
Intra-individual changes in circulating IGF-1 and IGF-1/IGFBP-3 molar ratio are associated with colorectal adenomatous polyps presence
(CANCER RESEARCH, 2011-04-15) Soubry, Adelheid; Sedjo, Rebecca; Wang, Frances; Byers, Tim; Rosen, Clifford; Yashin, Anatoli; Ukraintseva, Svetlana; Haffner, Steve; D'Agostino, Ralph; Il'yasova, Dora
Open Access
The second international conference "genetics of aging and longevity".
(Aging (Albany NY), 2012-05) Anisimov, Vladimir N; Bartke, Andrzej; Barzilai, Nir; Batin, Mikhail A; Blagosklonny, Mikhail V; Brown-Borg, Holly; Budovskaya, Yelena; Campisi, Judith; Friguet, Bertrand; Fraifeld, Vadim; Franceschi, Claudio; Gems, David; Gladyshev, Vadim; Gorbunova, Vera; Gudkov, Andrei V; Kennedy, Brian; Konovalenko, Maria; Kraemer, Brian; Moskalev, Alexey; Petropoulos, Isabelle; Pasyukova, Elena; Rattan, Suresh; Rogina, Blanka; Seluanov, Andrei; Shaposhnikov, Mikhail; Shmookler Reis, Robert; Tavernarakis, Nektarios; Vijg, Jan; Yashin, Anatoli; Zimniak, Piotr