Browsing by Author "Yu, S"

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    Inhibition of pulmonary fibrosis in mice by CXCL10 requires glycosaminoglycan binding and syndecan-4.
    (J Clin Invest, 2010-06) Jiang, D; Liang, J; Campanella, GS; Guo, R; Yu, S; Xie, T; Liu, N; Jung, Y; Homer, R; Meltzer, EB; Li, Y; Tager, AM; Goetinck, PF; Luster, AD; Noble, PW
    Pulmonary fibrosis is a progressive, dysregulated response to injury culminating in compromised lung function due to excess extracellular matrix production. The heparan sulfate proteoglycan syndecan-4 is important in mediating fibroblast-matrix interactions, but its role in pulmonary fibrosis has not been explored. To investigate this issue, we used intratracheal instillation of bleomycin as a model of acute lung injury and fibrosis. We found that bleomycin treatment increased syndecan-4 expression. Moreover, we observed a marked decrease in neutrophil recruitment and an increase in both myofibroblast recruitment and interstitial fibrosis in bleomycin-treated syndecan-4-null (Sdc4-/-) mice. Subsequently, we identified a direct interaction between CXCL10, an antifibrotic chemokine, and syndecan-4 that inhibited primary lung fibroblast migration during fibrosis; mutation of the heparin-binding domain, but not the CXCR3 domain, of CXCL10 diminished this effect. Similarly, migration of fibroblasts from patients with pulmonary fibrosis was inhibited in the presence of CXCL10 protein defective in CXCR3 binding. Furthermore, administration of recombinant CXCL10 protein inhibited fibrosis in WT mice, but not in Sdc4-/- mice. Collectively, these data suggest that the direct interaction of syndecan-4 and CXCL10 in the lung interstitial compartment serves to inhibit fibroblast recruitment and subsequent fibrosis. Thus, administration of CXCL10 protein defective in CXCR3 binding may represent a novel therapy for pulmonary fibrosis.
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    Methodological errors in corruption research: Recommendations for future research
    (Journal of International Business Studies, 2024-03-01) Delios, A; Malesky, EJ; Yu, S; Riddler, G
    The secretive, illegal, multidimensional, and ubiquitous nature of corruption leads to formidable difficulties in research design and measurement. When research fails to account for these challenges, it can lead to an empirical misalignment with concepts and theories of corruption, with inferential errors commensurately emerging. We define, measure, and track four common measurement errors and two common research design errors for papers on corruption published in international business/management and political economy journals in the 2000–2021 period. Our data marks a substantial opportunity to tighten the fit between theory and methods. We offer recommendations to accelerate improvements in empirical research on corruption, and indeed for other phenomena that are characterized by legal, moral, and social desirability concerns. These empirical recommendations contribute to more robust theory building.