Browsing by Author "Zhang, Dehui"
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Item Open Access Reductive ligation mediated one-step disulfide formation of S-nitrosothiols.(Org Lett, 2010-09-17) Zhang, Jiming; Li, Sheng; Zhang, Dehui; Wang, Hua; Whorton, A Richard; Xian, MingA one-step reductive ligation mediated disulfide formation of S-nitrosothiols was developed. This reaction involves the reaction of the S-nitroso group with phosphine-thioesters to form sulfenamide and thiolate intermediates, which then undergo a fast intermolecular disulfide formation to form stable conjugates. This reaction can be used to design new biosensors of S-nitrosated proteins.