Browsing by Author "Zhang, Qiang"

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Open Access
China's Internet Governance: A New Conceptualization of the Cyber-Sovereignty Model
(2019-04-09) Zhang, Qiang
In recent years, China’s Internet governance regime has been subject to increasing literature scrutiny and attention. A rising superpower, China’s vision for the Internet on domestic and international stages has far-reaching implications for the future cyber world order. While traditional theories of governance typically categorize China as a cyber-sovereign nation, I argue that China’s approach is more nuanced and can better be considered under a “flexible” cyber-sovereignty model. Through both a historical and case-study analysis, I suggest that this new model for China better considers the effects of new, rising capital forces—Chinese internet corporations—and explains the dynamic mix of rejection and assimilation into the existing regime that characterizes China’s current Internet governance strategy. Ultimately, this new model can help us conceptualize China’s vision and strategy for Internet governance, which can have far-ranging implications for the future of cyberspace and the Internet as we know it.
Open Access
Ectopic Expression of OsJAZs Alters Plant Defense and Development.
(International journal of molecular sciences, 2022-04) Sun, Baolong; Shang, Luyue; Li, Yang; Zhang, Qiang; Chu, Zhaohui; He, Shengyang; Yang, Wei; Ding, Xinhua
A key step in jasmonic acid (JA) signaling is the ligand-dependent assembly of a coreceptor complex comprising the F-box protein COI1 and JAZ transcriptional repressors. The assembly of this receptor complex results in proteasome-mediated degradation of JAZ repressors, which in turn bind and repress MYC transcription factors. Many studies on JAZs have been performed in Arabidopsis thaliana, but the function of JAZs in rice is largely unknown. To systematically reveal the function of OsJAZs, in this study, we compared the various phenotypes resulting from 13 OsJAZs via ectopic expression in Arabidopsis thaliana and the phenotypes of 12 AtJAZs overexpression (OE) lines. Phylogenetic analysis showed that the 25 proteins could be divided into three major groups. Yeast two-hybrid (Y2H) assays revealed that most OsJAZ proteins could form homodimers or heterodimers. The statistical results showed that the phenotypes of the OsJAZ OE plants were quite different from those of AtJAZ OE plants in terms of plant growth, development, and immunity. As an example, compared with other JAZ OE plants, OsJAZ11 OE plants exhibited a JA-insensitive phenotype and enhanced resistance to Pst DC3000. The protein stability after JA treatment of OsJAZ11 emphasized the specific function of the protein. This study aimed to explore the commonalities and characteristics of different JAZ proteins functions from a genetic perspective, and to screen genes with disease resistance value. Overall, the results of this study provide insights for further functional analysis of rice JAZ family proteins.
Open Access
GRK5 Deficiency Leads to Selective Basal Forebrain Cholinergic Neuronal Vulnerability.
(Sci Rep, 2016-05-19) He, Minchao; Singh, Prabhakar; Cheng, Shaowu; Zhang, Qiang; Peng, Wei; Ding, XueFeng; Li, Longxuan; Liu, Jun; Premont, Richard T; Morgan, Dave; Burns, Jeffery M; Swerdlow, Russell H; Suo, William Z
Why certain diseases primarily affect one specific neuronal subtype rather than another is a puzzle whose solution underlies the development of specific therapies. Selective basal forebrain cholinergic (BFC) neurodegeneration participates in cognitive impairment in Alzheimer's disease (AD), yet the underlying mechanism remains elusive. Here, we report the first recapitulation of the selective BFC neuronal loss that is typical of human AD in a mouse model termed GAP. We created GAP mice by crossing Tg2576 mice that over-express the Swedish mutant human β-amyloid precursor protein gene with G protein-coupled receptor kinase-5 (GRK5) knockout mice. This doubly defective mouse displayed significant BFC neuronal loss at 18 months of age, which was not observed in either of the singly defective parent strains or in the wild type. Along with other supporting evidence, we propose that GRK5 deficiency selectively renders BFC neurons more vulnerable to degeneration.
Open Access
The Power of Notes: The Psychological Impact of Music on Feelings of Spirituality
(2019-04-22) Zhang, Qiang
Although music has been used in spiritual contexts throughout history, not much is known about how the characteristics within music that elicit feelings associated with spirituality. This study was designed to shed light on this question through researching the effects of three psychological dimensions of music – intensity, valence, and depth – on feelings of spirituality in listeners. Additionally, the moderating effects of personal spirituality on the psychological effects of music were analyzed. One hundred and twelve participants listened to short clips of music that had been scaled with respect to their intensity, valence, and depth, and rated how they felt on 14 items. Results showed that each of the three dimensions was significantly associated with ratings associated with spirituality. Moreover, personal spirituality moderated the effects of music on ratings. These findings offer future directions through which to study music and spirituality.
Open Access
The Tsinghua-Lancet Commission on Healthy Cities in China: unlocking the power of cities for a healthy China.
(Lancet (London, England), 2018-04-17) Yang, Jun; Siri, José G; Remais, Justin V; Cheng, Qu; Zhang, Han; Chan, Karen KY; Sun, Zhe; Zhao, Yuanyuan; Cong, Na; Li, Xueyan; Zhang, Wei; Bai, Yuqi; Bi, Jun; Cai, Wenjia; Chan, Emily YY; Chen, Wanqing; Fan, Weicheng; Fu, Hua; He, Jianqing; Huang, Hong; Ji, John S; Jia, Peng; Jiang, Xiaopeng; Kwan, Mei-Po; Li, Tianhong; Li, Xiguang; Liang, Song; Liang, Xiaofeng; Liang, Lu; Liu, Qiyong; Lu, Yongmei; Luo, Yong; Ma, Xiulian; Schwartländer, Bernhard; Shen, Zhiyong; Shi, Peijun; Su, Jing; Wu, Tinghai; Yang, Changhong; Yin, Yongyuan; Zhang, Qiang; Zhang, Yinping; Zhang, Yong; Xu, Bing; Gong, Peng