Browsing by Author "Zhao, Yuchen"
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Item Open Access Characterization and Mechanism of Rigidity in Columns of Star-shaped Granular Particles(2020) Zhao, YuchenAn important challenge in the science of granular materials is to understand the connection between the shapes of individual grains and the macroscopic response of the aggregate. Granular packings of concave or elongated particles can form free-standing structures like walls or arches, in sharp contrast to the behaviors of spherical grains. For some particle shapes, such as staples, the rigidity arises from interlocking of pairs of particles, but the origins of rigidity for non-interlocking particles remains unclear. In addition to their intrinsic interest, these packings are relevant to lightweight and reconfigurable structures in civil, geotechnical and material engineering applications.
In this thesis, we report on experiments and numerical simulations of packings of star-shaped particles consisting of three mutually orthogonal sphero-cylinders whose centers coincide. The first set of experiments studies the chance of obtaining a free-standing column when the confining tube of the column is removed, which we will call it as ``intrinsic stability''. We prepare monodisperse packings of star-shaped particles with different length-to-arm diameter aspect ratio α, interparticle friction and particle-base friction. We also vary packing density by vibrating the packings when they are in the tube. We find that the intrinsic stability depends on packing dimension: columns of greater diameter or shorter height are more stable. Both arm length and interparticle friction can greatly increase the intrinsic stability, while the packing density and basal friction have limited effects on the intrinsic stability.
The second set of experiments involves stability of free-standing columns (prepared from the first set of experiments) under three different external perturbations: (1) base tilting; (2) static axial loading; and (3) vertical vibration. For the base tilting test, we gradually tilt the base of the column and observe column collapse as a function of tilt angle. We find that columns of low friction particles are more fragile than those of high friction particles. For the axial loading test, we gradually increase the loading on a column until it collapses. We find that tall columns are more fragile. For the vibration test, we apply vertical sinusoidal vibration from the base to destabilize the column. Both interparticle and basal friction improve packing stability in terms of increasing relaxation time under vibration. We also find that tall columns are more sensitive to the vibration in the sense that they collapse faster than short ones under the same vibration.
In the third set of experiments, we vary α and subject the packings to quasistatic direct shear. For small α, we observe a finite yield stress. For large α, however, the packings become rigid when sheared, supporting stresses that increase sharply with increasing strain. Analysis of x-ray micro-computed tomography data collected during the shear reveals that the stiffening is associated with a tilted, oblate cluster of particles near the nominal shear plane in which particle deformation and average contact number both increase.
Molecular dynamics simulations that closely match the third experiments are used to investigate the finite yield stress and the stiffening. In simulation, interparticle contact forces are known to us. For yield packings (small α), simulations suggest no apparent cohesion. For stiffening packings (large α), simulation results show that the particles are collectively under tension along one direction even though they do not interlock pairwise. These tensions come from contact forces with large associated torques, and they are perpendicular to the compressive stresses in the packing. They counteract the tendency to dilate, thus stabilizing the particle cluster.
Item Open Access Genetic variants of BIRC3 and NRG1 in the NLRP3 inflammasome pathway are associated with non-small cell lung cancer survival.(American journal of cancer research, 2020-01) Tang, Dongfang; Liu, Hongliang; Zhao, Yuchen; Qian, Danwen; Luo, Sheng; Patz, Edward F; Su, Li; Shen, Sipeng; ChristianI, David C; Gao, Wen; Wei, QingyiThe nod-like receptor protein 3 (NLRP3) is one of the most characterized inflammasomes, and its genetic variation and functional dysregulation are involved in pathogenesis of several cancers. To systematically evaluate the role of NLRP3 in predicting outcomes of patients with non-small cell lung cancer (NSCLC), we performed a two-phase analysis for associations between genetic variants in NLRP3 inflammasome pathway genes and NSCLC survival by using a published genome-wide association study (GWAS) dataset from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. We used multivariate Cox proportional hazards regression analysis with Bayesian false discovery probability (≤0.80) for multiple testing correction to evaluate associations between 20,730 single-nucleotide polymorphisms (SNPs) in 176 genes and overall survival of 1,185 NSCLC patients from the PLCO trial. We further validated the identified significant SNPs in another GWAS dataset with survival data from 984 NSCLC patients of the Harvard Lung Cancer Susceptibility (HLCS) study. The results showed that two independent SNPs in two different genes (i.e., BIRC3 rs11225211 and NRG1 rs4733124) were significantly associated with the NSCLC overall survival, with a combined hazards ratio (HR) of 0.83 [95% confidence interval (CI) = 0.74-0.93 and P = 0.0009] and 1.18 (95% CI = 1.06-1.31) and P = 0.002], respectively. However, further expression quantitative trait loci (eQTL) analysis showed no evidence for correlations between the two SNPs and mRNA expression levels of corresponding genes. These results indicated that genetic variants in the NLRP3 imflammasome pathway gene-sets might be predictors of NSCLC survival, but the molecular mechanisms underlying the observed associations warrant further investigations.Item Open Access VR Touch Museum(2018) Zhao, YuchenIn recent years, digital technology has become ubiquitous in the museum. They have changed the ways museums document, preserve and present cultural heritage. Now, we are exploring if there are some ways that could provide more historical context to a displayed object and make an exhibition more immersive. Therefore, we did a project called “The Virtual Reality Touch Museum” and used an experiment to test if such museum performs better on “Presence” and learning achievements. As the results show, our VR Touch Museum was outstanding in “presence” but more research is necessary to verify how effective it is for learning.
Item Open Access Yielding, rigidity, and tensile stress in sheared columns of hexapod granules(Physical Review E) Zhao, Yuchen; Barés, Jonathan; Socolar, Joshua ESGranular packings of non-convex or elongated particles can form free-standing structures like walls or arches. For some particle shapes, such as staples, the rigidity arises from interlocking of pairs of particles, but the origins of rigidity for non-interlocking particles remains unclear. We report on experiments and numerical simulations of sheared columns of ``hexapods,'' particles consisting of three mutually orthogonal sphero-cylinders whose centers coincide. We vary the length-to-diameter aspect ratio, $\alpha$, of the sphero-cylinders and subject the packings to quasistatic direct shear. For small $\alpha$, we observe a finite yield stress. For large $\alpha$, however, the column becomes rigid when sheared, supporting stresses that increase sharply with increasing strain. Analysis of X-ray micro-computed tomography (Micro-CT) data collected during the shear reveals that the stiffening is associated with a tilted, oblate cluster of hexapods near the nominal shear plane in which particle deformation and average contact number both increase. Simulation results show that the particles are collectively under tension along one direction even though they do not interlock pairwise. These tensions comes from contact forces carrying large torques, and they are perpendicular to the compressive stresses in the packing. They counteract the tendency to dilate, thus stabilize the particle cluster.