Browsing by Subject "Afghanistan"
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Item Open Access Allopregnanolone Levels Are Inversely Associated with Self-Reported Pain Symptoms in U.S. Iraq and Afghanistan-Era Veterans: Implications for Biomarkers and Therapeutics.(Pain Med, 2016-01) Naylor, Jennifer C; Kilts, Jason D; Szabo, Steven T; Dunn, Charlotte E; Keefe, Francis J; Tupler, Larry A; Shampine, Lawrence J; Morey, Rajendra A; Strauss, Jennifer L; Hamer, Robert M; Wagner, H Ryan; MIRECC Workgroup; Marx, Christine EBACKGROUND AND OBJECTIVES: Pain symptoms are common among Iraq/Afghanistan-era veterans, many of whom continue to experience persistent pain symptoms despite multiple pharmacological interventions. Preclinical data suggest that neurosteroids such as allopregnanolone demonstrate pronounced analgesic properties, and thus represent logical biomarker candidates and therapeutic targets for pain. Allopregnanolone is also a positive GABAA receptor modulator with anxiolytic, anticonvulsant, and neuroprotective actions in rodent models. We previously reported inverse associations between serum allopregnanolone levels and self-reported pain symptom severity in a pilot study of 82 male veterans. METHODS: The current study investigates allopregnanolone levels in a larger cohort of 485 male Iraq/Afghanistan-era veterans to attempt to replicate these initial findings. Pain symptoms were assessed by items from the Symptom Checklist-90-R (SCL-90-R) querying headache, chest pain, muscle soreness, and low back pain over the past 7 days. Allopregnanolone levels were quantified by gas chromatography/mass spectrometry. RESULTS: Associations between pain ratings and allopregnanolone levels were examined with Poisson regression analyses, controlling for age and smoking. Bivariate nonparametric Mann–Whitney analyses examining allopregnanolone levels across high and low levels of pain were also conducted. Allopregnanolone levels were inversely associated with muscle soreness [P = 0.0028], chest pain [P = 0.032], and aggregate total pain (sum of all four pain items) [P = 0.0001]. In the bivariate analyses, allopregnanolone levels were lower in the group reporting high levels of muscle soreness [P = 0.001]. CONCLUSIONS: These findings are generally consistent with our prior pilot study and suggest that allopregnanolone may function as an endogenous analgesic. Thus, exogenous supplementation with allopregnanolone could have therapeutic potential. The characterization of neurosteroid profiles may also have biomarker utility.Item Open Access Disruptive Events and Global Jihad Over Time(2020-03) Buchanan, MatthewYears of scholarship have produced academic models to evaluate pathways to radicalization and have attempted to explain individual risk factors for radicalization. However, these studies do not consider how changes to sociopolitical conditions over time affect and drive jihad. Using data from the Western Jihadism Project (WJP), I drafted a timeline (Figure 4.1) from the Soviet invasion of Afghanistan to the present that overlays a polygon depicting the frequency of plots against Western targets with selected disruptive events. To conduct my analysis of each disruptive event included on the timeline, I created a chain of influence model (Figure 3.2). The model incorporates my research, Judea Pearl’s causal models (2018), and the North Carolina State University Lab for Analytic Science’s (NC State-LAS) Radicalization Working Group’s (RWG) socioecological model. The model also serves as my recommended inclusion criteria for events on the timeline. By testing my model on each disruptive event, I found the following: 1. The Soviet occupation of Afghanistan’s importance cannot be underestimated as a driving/enabling force in the formation of Al-Qaeda and the global jihad ideology. 2. The United States-led coalition’s involvement in repelling Iraqi forces from Kuwait strengthened the West versus Islam narrative. 3. The September 11, 2001 attacks were inspirational for global jihad; triggering an increase in the number of plots targeting the West. 4. The United States invasion of Iraq temporarily decreased plots targeting the West, but led to increased plots in Europe and the Islamic State’s formation in the long-term. 5. The information technology boom beginning in 2007 so effectively enables my model’s mechanism of influence, it merits inclusion on the timeline. 6. The Islamic State became its own disruptive event, though its continued influence remains to be seen. My findings and the trends identified on the timeline emphasize the need for policy makers to consider jihadi’s perception of disruptive events when deciding how to respond to such events. Finally, while my chain of influence model is used as an explanatory model in this paper, it has promise as a predictive model for analyzing global jihad’s potential responses to future disruptive events.Item Open Access From the Graveyard of Empires to the Queen City: Exploring the Status of Resettled Afghans in Charlotte, North Carolina and the Efficacy of Volunteer Partnership(2024-04-30) Schwartzbauer, NathanThis Master's Project attempts to better illuminate the status of resettled Afghans in Charlotte, North Carolina as of 2024. The project explores the perceptions of Afghan households about their resettlement, the assistance available, and their involvement with groups of local churches and other volunteers. The author created a survey that local Charlotte Afghan interpreters administered to 31 resettled Afghan respondents. Many of the survey questions mirrored those from a 2023 national survey of resettled Afghans from the Office of Refugee Resettlement (ORR) in the Administration for Children and Families (part of the U.S. Department of Health and Human Services). The Master's Project survey innovates beyond ORR questions to provide more information about the status of Charlotte Afghans specifically. The paper provides some contrast with previous resettlement experiences in the United States and North Carolina – specifically, the Vietnamese, Montagnards, and Iraqis. The author proposes areas of enhanced focus for Charlotte volunteers, nonprofits, resettlement agencies, and local policymakers working with resettled Afghans. The paper highlights the specific focus areas of immigration status adjustment, childcare access, and addressing ethnic disparities within the Afghan community itself. The project also emphasizes the importance of sustaining local volunteer partnerships at the most immediate level towards approaching problem-solving with resettled Afghan families – which is characterized as “subsidiarity” in the paper. The author suggests that larger resettlement organizations and support resources should only assist with tasks that cannot be met by local volunteer partners. The paper proposes future areas of exploration potential, especially in consideration of longer-term partnerships lasting longer than three months. The work does not claim to be definitive in providing a single set of solutions to helping resettled Afghans. Rather, the work seeks to contribute useful knowledge by creating more awareness among policymakers and community stakeholders in Charlotte, along with any other interested parties in North Carolina and beyond.Item Open Access Item Open Access Testing Obama's Withdrawal Timeline Hypothesis in Afghanistan(2011) Koprowski, MichaelThe Obama Administration argued that a publicly announced withdrawal timeline would help further US counterinsurgency (COIN) objectives in Afghanistan by incentivizing better behavior from the Karzai government and the Afghan people. An endless troop commitment, the Administration believed, fostered a dependency that allowed, and possibly even encouraged, poor governance and rampant corruption to persist - a timeline, it claimed, would sever the continual dependency by signaling that US commitment would not last forever, serving to focus, energize, and quicken the Karzai government's efforts to build a secure, durable, self-sufficient state. Moreover, it argued, a timeline would send a message of urgency to the Afghan people to take charge of their own affairs and to consent to their government's rule in greater numbers. In this essay, I test the "Obama timeline hypothesis" in order to determine whether it is truly likely to produce the positive change that the Administration claims it will. By utilizing a mix of consistent historical predictors, deductive logic based on contemporary COIN theory, and currently available evidence, I conclude that the withdrawal timeline has not produced, and likely will not produce, the results that the Administration claimed it would and that, on the whole, it has likely engendered perverse incentives for the Karzai government and the Afghan people that run contrary to America's desired COIN objectives. More broadly, the Afghan case, along with America's recent experience in Iraq, should make US policymakers deeply skeptical of assertions that withdrawal timelines can serve as an effective policy tool for changing the behaviors of key regional actors.
Item Open Access Troy in America: Soldier Suicide in American War Literature(2021) Portis, StoneyTroy in America: Soldier Suicide in American War Literature attempts to illuminate how a war mentality forces an acceptance of mortality that not only brings out the irrationality of life itself, but also makes suicide more thinkable. This dissertation is therefore about the different reasons soldiers and veterans depicted in literature choose to die by suicide, but also those who consider it and choose not to. Troy in America draws on examples of suicide found in Ancient Greek literature to contextualize similar genres of suicide depicted in American war literature. Four Ancient Greek warriors suffer from different forms of suicidal behavior: Achilles’s grief, Odysseus’s despair, Ajax’s honor, and Philoctetes’s pain. Each hero’s suicidality is characterized by unique features that forms a discrete archetype that endures and informs characters found in literature about the American Civil War to the wars in Afghanistan and Iraq.
The authors of the texts analyzed in Troy in America appear to be in substantial agreement that the experience of combat can be so troubling that, for some of its participants and veterans, suicide seems to be an answer. For many survivors, the end of war does not mark the end of their suffering. War removes its participants from society in an effort to preserve it. War thus becomes, in effect, a trip to the Underworld; a liminal experience where the social order becomes available for inspection. As a result, coming home can be as difficult emotionally as combat. After experiencing the irrationality of war and gaining insight into the irrationality of life, the warrior must change in order to return to society. But some do not change; instead, they choose to end their lives.