Browsing by Subject "Africa"
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Item Open Access A revised generic classification of vittarioid ferns (Pteridaceae) based on molecular, micromorphological, and geographic data(Taxon, 2016-08-01) Schuettpelz, E; Chen, C; Kessler, M; Pinson, JB; Johnson, G; Davila, A; Cochran, AT; Huiet, L; Pryer, KM© International Association for Plant Taxonomy (IAPT) 2016. Vittarioid ferns compose a well-supported clade of 100-130 species of highly simplified epiphytes in the family Pteridaceae. Generic circumscriptions within the vittarioid clade were among the first in ferns to be evaluated and revised based on molecular phylogenetic data. Initial analyses of rbcL sequences revealed strong geographic structure and demonstrated that the two largest vittarioid genera, as then defined, each had phylogenetically distinct American and Old World components. The results of subsequent studies that included as many as 36 individuals of 33 species, but still relied on a single gene, were generally consistent with the early findings. Here, we build upon the previous datasets, incorporating many more samples (138 individuals representing 72 species) and additional plastid markers (atpA, chlN, rbcL, rpoA). Analysis of our larger dataset serves to better characterize known lineages, reveals new lineages, and ultimately uncovers an underlying geographic signal that is even stronger than was previously appreciated. In our revised generic classification, we recognize a total of eleven vittarioid genera. Each genus, including the new genus Antrophyopsis (Benedict) Schuettp., stat. nov., is readily diagnosable based on morphology, with micromorphological characters related to soral paraphyses and spores complementing more obvious features such as venation and the distribution of sporangia. A key to the currently recognized vittarioid genera, brief generic descriptions, and five new species combinations are provided.Item Open Access Above-ground biomass and structure of 260 African tropical forests.(Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2013-01) Lewis, Simon L; Sonké, Bonaventure; Sunderland, Terry; Begne, Serge K; Lopez-Gonzalez, Gabriela; van der Heijden, Geertje MF; Phillips, Oliver L; Affum-Baffoe, Kofi; Baker, Timothy R; Banin, Lindsay; Bastin, Jean-François; Beeckman, Hans; Boeckx, Pascal; Bogaert, Jan; De Cannière, Charles; Chezeaux, Eric; Clark, Connie J; Collins, Murray; Djagbletey, Gloria; Djuikouo, Marie Noël K; Droissart, Vincent; Doucet, Jean-Louis; Ewango, Cornielle EN; Fauset, Sophie; Feldpausch, Ted R; Foli, Ernest G; Gillet, Jean-François; Hamilton, Alan C; Harris, David J; Hart, Terese B; de Haulleville, Thales; Hladik, Annette; Hufkens, Koen; Huygens, Dries; Jeanmart, Philippe; Jeffery, Kathryn J; Kearsley, Elizabeth; Leal, Miguel E; Lloyd, Jon; Lovett, Jon C; Makana, Jean-Remy; Malhi, Yadvinder; Marshall, Andrew R; Ojo, Lucas; Peh, Kelvin S-H; Pickavance, Georgia; Poulsen, John R; Reitsma, Jan M; Sheil, Douglas; Simo, Murielle; Steppe, Kathy; Taedoumg, Hermann E; Talbot, Joey; Taplin, James RD; Taylor, David; Thomas, Sean C; Toirambe, Benjamin; Verbeeck, Hans; Vleminckx, Jason; White, Lee JT; Willcock, Simon; Woell, Hannsjorg; Zemagho, LiseWe report above-ground biomass (AGB), basal area, stem density and wood mass density estimates from 260 sample plots (mean size: 1.2 ha) in intact closed-canopy tropical forests across 12 African countries. Mean AGB is 395.7 Mg dry mass ha⁻¹ (95% CI: 14.3), substantially higher than Amazonian values, with the Congo Basin and contiguous forest region attaining AGB values (429 Mg ha⁻¹) similar to those of Bornean forests, and significantly greater than East or West African forests. AGB therefore appears generally higher in palaeo- compared with neotropical forests. However, mean stem density is low (426 ± 11 stems ha⁻¹ greater than or equal to 100 mm diameter) compared with both Amazonian and Bornean forests (cf. approx. 600) and is the signature structural feature of African tropical forests. While spatial autocorrelation complicates analyses, AGB shows a positive relationship with rainfall in the driest nine months of the year, and an opposite association with the wettest three months of the year; a negative relationship with temperature; positive relationship with clay-rich soils; and negative relationships with C : N ratio (suggesting a positive soil phosphorus-AGB relationship), and soil fertility computed as the sum of base cations. The results indicate that AGB is mediated by both climate and soils, and suggest that the AGB of African closed-canopy tropical forests may be particularly sensitive to future precipitation and temperature changes.Item Open Access Adolescents' and caregivers' perceptions of caregiver-provided testing and HIV self-testing using oral mucosal transudate tests in Zimbabwe: a short report.(AIDS care, 2020-04-16) Rainer, Crissi; Chihota, Belinda; Dziva Chikwari, Chido; McHugh, Grace; Dauya, Ethel; Mujuru, Hilda; Ferrand, Rashida A; Stewart, Kearsley AUptake of HIV testing remains lower among children and adolescents compared to adults. This study explored adolescents' perceptions of HIV self-testing (HIVST) and caregivers' perceptions of testing their children using an oral mucosal transudate (OMT) rapid HIV test (caregiver-provided testing). We conducted 31 interviews with adolescents aged 16-18 years and caregivers of children aged 2-15 years who received an OMT test. Participants described barriers to HIV testing including lack of privacy and the potential for discrimination by community members towards children and adolescents who received an HIV test. Most participants felt caregiver-provided testing and HIVST could address these barriers through increased privacy. Some participants expressed worry about their ability to correctly perform the OMT and their anxious reactions to a positive result. Counseling and assistance from health care workers were viewed as ways to alleviate concerns. Concerns shaped participants' preferences for facility-based HIVST and caregiver-provided testing. Findings demonstrate HIVST performed by adolescents and caregiver-provided testing could increase the uptake of HIV testing. Concerns related to being able to test correctly and the availability of post-test counseling must be addressed in any future delivery mechanisms.Item Open Access Against the Grain: Reclaiming the Life I Left Behind(2015-06-12) Brill, Margaret* Designated as an Exemplary Master's Project for 2014-15*
Against the Grain revisits a period of my life long neglected: the 20 years between my graduation from London University with a BA in African history in 1964 and my professional reinvention as an academic librarian. In keeping with second wave feminism's emphasis on professional life, I had dismissed this period of my life as subservient to "patriarchy": I was the dependent wife of a Foreign Service officer. At this point in my personal and professional history I have come to recognize this was anything but a prelude to a more real existence. With the benefit of historically informed insights, I recognize that I lived for extended periods in hotspots throughout Africa and beyond in the nineteen sixties and seventies, at moments of world historical significance: Ghana, Burundi, South Africa, Bulgaria, and Zaire. Moreover, because of my relative independence I was able to develop relationships that continue to shape my understanding of this complex period in US foreign policy. In classic feminist fashion, the personal and the political were inextricable. Somewhat more against the feminist grain are the rich experiences and examined life of an adventurous, independent woman in a traditional marriage. I eventually regained my independence; when I remarried and moved to North Carolina in 1984, I put those years behind me. Viewing that part of my life in historical context has revealed that, even without a career, I led a full and rich life that has helped to shape my identity today.Item Open Access An Assessment of Health Outcomes Among Orphans in the Positive Outcomes for Orphans Study in Rural Settings of Kenya and Tanzania(2011) Achwoka, Dunstan EugineObjectives: To compare measures of health and health quality between Orphans and Vulnerable Children (OVC) in different living arrangements-- institutional and community care; and to correlate different measures of OVC health and health quality using clinical, laboratory and quality of life instruments.
Design: Cross-sectional study.
Setting: Two rural districts (sites) in East Africa, Bungoma in Kenya, and Kilimanjaro in Tanzania.
Participants: 77 male and 45 female OVC aged 16-18 years (N=122). Participants, who had attained a minimum age of 16 at the date of interview, were selected from the larger sample of OVC in the Positive Outcomes for Orphans (POFO) study. POFO, a longitudinal study in five less wealthy countries that started in 2006, obtained its sample through cluster randomization.
Methods: To obtain self-ratings of OVC physical health, OVC responded to an interviewer administered SF-36 questionnaire, a multipurpose generic measure of health status. A neutral examiner then measured OVC physical health using 4 clinical variables: a physical health examination, body mass index, hemoglobin level, and the Harvard physical fitness score.
Main Outcome Measures: SF-36 scores presented as a two component score- the physical health and mental health composite sub-scores. For physical health, normal findings for age were considered as meeting the threshold for good physical health.
Results: Of the 122 OVC, 89 (73%) lived in the community while 33 (27%) lived in institutional settings. For the SF-36, the mean physical composite score for the entire study population was 50.6 (SD=6.2). Mean body mass index (BMI) was 19.3 (SD=2.4). Mean hemoglobin was found to be 13.2g/dl (SD=1.8). The average Harvard physical fitness score was found to be 40.7(SD=16.9). Pearson's correlations between SF-36 Physical Functioning and hemoglobin, BMI, and the Harvard Step-Test fitness score were 0.1, 0.1, and -0.1 respectively. There was no evidence that self-rating of OVC health outcomes differed by living arrangement. Using paired t-tests for continuous variables and chi-square tests for categorical variables, no significant p- values were obtained at the 95% level. Using a threshold of vision 20/20 for normal vision, 91.0% of community OVC and 78.8% of OVC in institutions had normal vision (p=0.07).
Conclusion: Although this study did not detect significant differences in self-reported measures of health among OVC in different living arrangements, physical examination revealed a slightly high incidence of poor vision among those living in institutions. In this sample, the correlations between SF-36 physical functioning sub-score and 3 physical health outcomes of BMI, hemoglobin, and the Harvard Step-test fitness score were weak.
Item Open Access Archives in Stone: Cemeteries, Burial, and Urban Ownership in Late Colonial Ghana(Journal of Urban History, 2024-01-01) Balakrishnan, SWhile many scholars have examined the influence of European law, writing, and record-keeping on African land rights and property, few have analyzed semi-textual records such as cemetery gravestones. This essay argues that urban cemeteries, introduced by the British colonial state to the Gold Coast Colony (southern Ghana) in the nineteenth century, became archives in stone. As one of the few public records forums available inside Gold Coast towns, cemeteries offered basic, but crucial, information. They indirectly dated immigration history and reflected ancestral political status. Over the course of colonial rule, Gold Coast citizens petitioned the state to have their elders buried in particular cemeteries to augment their claims to land and authority. This essay demonstrates that urban ownership—the status of belonging to a town as an authochthon—came to depend partly upon cemetery burial. Like any archive, cemeteries were highly curated collections, shaping legal contestations over residency, leadership, and land ownership.Item Open Access Assessing Africa-Wide Pangolin Exploitation by Scaling Local Data(Conservation Letters, 2018-03) Ingram, DJ; Coad, L; Abernethy, KA; Maisels, F; Stokes, EJ; Bobo, KS; Breuer, T; Gandiwa, E; Ghiurghi, A; Greengrass, E; Holmern, T; Kamgaing, TOW; Ndong Obiang, AM; Poulsen, JR; Schleicher, J; Nielsen, MR; Solly, H; Vath, CL; Waltert, M; Whitham, CEL; Wilkie, DS; Scharlemann, JPWCopyright and Photocopying: © 2017 The Authors. Conservation Letters published by Wiley Periodicals, Inc. Overexploitation is one of the main pressures driving wildlife closer to extinction, yet broad-scale data to evaluate species’ declines are limited. Using African pangolins (Family: Pholidota) as a case study, we demonstrate that collating local-scale data can provide crucial information on regional trends in exploitation of threatened species to inform conservation actions and policy. We estimate that 0.4-2.7 million pangolins are hunted annually in Central African forests. The number of pangolins hunted has increased by ∼150% and the proportion of pangolins of all vertebrates hunted increased from 0.04% to 1.83% over the past four decades. However, there were no trends in pangolins observed at markets, suggesting use of alternative supply chains. The price of giant (Smutsia gigantea) and arboreal (Phataginus sp.) pangolins in urban markets has increased 5.8 and 2.3 times respectively, mirroring trends in Asian pangolins. Efforts and resources are needed to increase law enforcement and population monitoring, and investigate linkages between subsistence hunting and illegal wildlife trade.Item Open Access Challenges of Maintaining Good Clinical Laboratory Practices in Low-Resource Settings: A Health Program Evaluation Framework Case Study From East Africa.(Am J Clin Pathol, 2016-08) Zhang, Helen L; Omondi, Michael W; Musyoka, Augustine M; Afwamba, Isaac A; Swai, Remigi P; Karia, Francis P; Muiruri, Charles; Reddy, Elizabeth A; Crump, John A; Rubach, Matthew POBJECTIVES: Using a clinical research laboratory as a case study, we sought to characterize barriers to maintaining Good Clinical Laboratory Practice (GCLP) services in a developing world setting. METHODS: Using a US Centers for Disease Control and Prevention framework for program evaluation in public health, we performed an evaluation of the Kilimanjaro Christian Medical Centre-Duke University Health Collaboration clinical research laboratory sections of the Kilimanjaro Clinical Research Institute in Moshi, Tanzania. Laboratory records from November 2012 through October 2014 were reviewed for this analysis. RESULTS: During the 2-year period of study, seven instrument malfunctions suspended testing required for open clinical trials. A median (range) of 9 (1-55) days elapsed between instrument malfunction and biomedical engineer service. Sixteen (76.1%) of 21 suppliers of reagents, controls, and consumables were based outside Tanzania. Test throughput among laboratory sections used a median (range) of 0.6% (0.2%-2.7%) of instrument capacity. Five (55.6%) of nine laboratory technologists left their posts over 2 years. CONCLUSIONS: These findings demonstrate that GCLP laboratory service provision in this setting is hampered by delays in biomedical engineer support, delays and extra costs in commodity procurement, low testing throughput, and high personnel turnover.Item Open Access China's Health Aid to Africa(2017-04-29) Tesha, FlorenceSino-Africa relations involve China’s foreign aid to African countries. There are many questions surrounding China’s foreign aid, such as its scope, its impact, and whether it is altruistic or opportunistic. This thesis provides an analysis of China’s health aid to Sub-Saharan Africa, drawing in part on research I conducted in Dar es Salaam, Tanzania, on China’s health services. This paper begins with an analysis of the history of the relationship between China and Africa, while taking into account colonialism. This history is important in understanding the complexity of China’s engagement in African countries. This paper then focuses on two components of China’s health aid: Traditional Chinese Medicine (TCM) and the relationship between Chinese doctors and the African communities they work in. Results suggest that TCM offers an affordable alternative form of medicine to most Africans in low-income countries. However, there is still uncertainty about whether the provision of free TCM by the Chinese government is altruistic or a strategy to promote Chinese products in the African market. Additionally, the research shows that there is a lack of interaction between Chinese doctors and the African local communities. The thesis concludes that, regardless of China’s motivations, foreign aid alone does not result in the development of a country. There is a need for African governments and societies to take an active role in the allocation of health aid to their people so that it best serves communities. Thus, instead of indulging in the debate on whether health aid is altruistic or not, African countries should focus on finding ways to use aid to advance their own best interests.Item Open Access Chinese medical teams in Africa: a flagship program facing formidable challenges.(Journal of global health, 2019-06) Chen, Shu; Pender, Michelle; Jin, Nan; Merson, Michael; Tang, Shenglan; Gloyd, StephenItem Open Access Climate change, disease range shifts, and the future of the Africa lion.(Conservation biology : the journal of the Society for Conservation Biology, 2018-10) Carter, Neil H; Bouley, Paola; Moore, Sean; Poulos, Michael; Bouyer, Jérémy; Pimm, Stuart LItem Open Access Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus.(Nature, 2013-04-25) Liao, Hua-Xin; Lynch, Rebecca; Zhou, Tongqing; Gao, Feng; Alam, S Munir; Boyd, Scott D; Fire, Andrew Z; Roskin, Krishna M; Schramm, Chaim A; Zhang, Zhenhai; Zhu, Jiang; Shapiro, Lawrence; NISC Comparative Sequencing Program; Mullikin, James C; Gnanakaran, S; Hraber, Peter; Wiehe, Kevin; Kelsoe, Garnett; Yang, Guang; Xia, Shi-Mao; Montefiori, David C; Parks, Robert; Lloyd, Krissey E; Scearce, Richard M; Soderberg, Kelly A; Cohen, Myron; Kamanga, Gift; Louder, Mark K; Tran, Lillian M; Chen, Yue; Cai, Fangping; Chen, Sheri; Moquin, Stephanie; Du, Xiulian; Joyce, M Gordon; Srivatsan, Sanjay; Zhang, Baoshan; Zheng, Anqi; Shaw, George M; Hahn, Beatrice H; Kepler, Thomas B; Korber, Bette TM; Kwong, Peter D; Mascola, John R; Haynes, Barton FCurrent human immunodeficiency virus-1 (HIV-1) vaccines elicit strain-specific neutralizing antibodies. However, cross-reactive neutralizing antibodies arise in approximately 20% of HIV-1-infected individuals, and details of their generation could provide a blueprint for effective vaccination. Here we report the isolation, evolution and structure of a broadly neutralizing antibody from an African donor followed from the time of infection. The mature antibody, CH103, neutralized approximately 55% of HIV-1 isolates, and its co-crystal structure with the HIV-1 envelope protein gp120 revealed a new loop-based mechanism of CD4-binding-site recognition. Virus and antibody gene sequencing revealed concomitant virus evolution and antibody maturation. Notably, the unmutated common ancestor of the CH103 lineage avidly bound the transmitted/founder HIV-1 envelope glycoprotein, and evolution of antibody neutralization breadth was preceded by extensive viral diversification in and near the CH103 epitope. These data determine the viral and antibody evolution leading to induction of a lineage of HIV-1 broadly neutralizing antibodies, and provide insights into strategies to elicit similar antibodies by vaccination.Item Open Access Coercive Legacies: From Rebel Governance to Authoritarian Control(The Journal of Politics, 2023-09-16) Liu, SItem Open Access Comparing actual and perceived causes of fever among community members in a low malaria transmission setting in northern Tanzania.(Trop Med Int Health, 2013-11) Hertz, Julian T; Munishi, O Michael; Sharp, Joanne P; Reddy, Elizabeth A; Crump, John AOBJECTIVE: To compare actual and perceived causes of fever in northern Tanzania. METHODS: In a standardised survey, heads of households in 30 wards in Moshi, Tanzania, were asked to identify the most common cause of fever for children and for adults. Responses were compared to data from a local hospital-based fever aetiology study that used standard diagnostic techniques. RESULTS: Of 810 interviewees, the median (range) age was 48 (16, 102) years and 509 (62.8%) were women. Malaria was the most frequently identified cause of fever, cited by 353 (43.6%) and 459 (56.7%) as the most common cause of fever for children and adults, respectively. In contrast, malaria accounted for 8 (2.0%) of adult and 6 (1.3%) of paediatric febrile admissions in the fever aetiology study. Weather was the second most frequently cited cause of fever. Participants who identified a non-biomedical explanation such as weather as the most common cause of fever were more likely to prefer a traditional healer for treatment of febrile adults (OR 2.7, P < 0.001). Bacterial zoonoses were the most common cause of fever among inpatients, but no interviewees identified infections from animal contact as the most common cause of fever for adults; two (0.2%) identified these infections as the most common cause of fever for children. CONCLUSIONS: Malaria is perceived to be a much more common cause of fever than hospital studies indicate, whereas other important diseases are under-appreciated in northern Tanzania. Belief in non-biomedical explanations of fever is common locally and has important public health consequences.Item Open Access Dynamic and Lasting Impacts: Socioeconomic Effects of Protracted Refugee Camps on Host Communities in Tanzania(2009-12) Han, Min CourtneyPoor sub-Saharan African countries are more likely to host long-term refugee situations in the 21st century than in previous decades. Many hosting governments have restricted refugees to camps because they consider long-term refugees to be economic burdens. Refugee-affiliated organizations have attempted to address this complaint by exploring development projects for locals living in refugee-affected areas. To investigate how refugees and NGOs actually impact host communities during and after camp protraction, three Tanzanian villages near a recently closed fourteen-year-old refugee camp were assessed using a mixed-methods research approach. Impacts from camp presence were analyzed based on those caused by refugees themselves, and those by refugee-affiliated humanitarian organizations. Focus groups discussions provide evidence of four different stages of camp presence effects: high instability during initial presence, positive interactions for eight years, increased crime and tensions ten years after initial contact, and lagging NGO development and compensation interventions during and after camp disbandment. NGO benefits for hosts also grew 5-6 years after camp construction. Household surveys indicated that refugee camp presence did not appear to noticeably affect village wealth, but could contribute to large economic impacts on specific households based on the household’s absorption capacity to take advantage of refugee-related opportunities. To reduce tension, increase absorption capacity and protect vulnerable host populations, NGOs should coordinate skill-exchange programs, community-level governance structures and community crime watch programs between refugees and hosts.Item Open Access Epidemiology of Coxiella burnetii infection in Africa: a OneHealth systematic review.(PLoS Negl Trop Dis, 2014-04) Vanderburg, Sky; Rubach, Matthew P; Halliday, Jo EB; Cleaveland, Sarah; Reddy, Elizabeth A; Crump, John ABACKGROUND: Q fever is a common cause of febrile illness and community-acquired pneumonia in resource-limited settings. Coxiella burnetii, the causative pathogen, is transmitted among varied host species, but the epidemiology of the organism in Africa is poorly understood. We conducted a systematic review of C. burnetii epidemiology in Africa from a "One Health" perspective to synthesize the published data and identify knowledge gaps. METHODS/PRINCIPAL FINDINGS: We searched nine databases to identify articles relevant to four key aspects of C. burnetii epidemiology in human and animal populations in Africa: infection prevalence; disease incidence; transmission risk factors; and infection control efforts. We identified 929 unique articles, 100 of which remained after full-text review. Of these, 41 articles describing 51 studies qualified for data extraction. Animal seroprevalence studies revealed infection by C. burnetii (≤13%) among cattle except for studies in Western and Middle Africa (18-55%). Small ruminant seroprevalence ranged from 11-33%. Human seroprevalence was <8% with the exception of studies among children and in Egypt (10-32%). Close contact with camels and rural residence were associated with increased seropositivity among humans. C. burnetii infection has been associated with livestock abortion. In human cohort studies, Q fever accounted for 2-9% of febrile illness hospitalizations and 1-3% of infective endocarditis cases. We found no studies of disease incidence estimates or disease control efforts. CONCLUSIONS/SIGNIFICANCE: C. burnetii infection is detected in humans and in a wide range of animal species across Africa, but seroprevalence varies widely by species and location. Risk factors underlying this variability are poorly understood as is the role of C. burnetii in livestock abortion. Q fever consistently accounts for a notable proportion of undifferentiated human febrile illness and infective endocarditis in cohort studies, but incidence estimates are lacking. C. burnetii presents a real yet underappreciated threat to human and animal health throughout Africa.Item Open Access Epidemiology of Leptospirosis in Africa: A Systematic Review of a Neglected Zoonosis and a Paradigm for 'One Health' in Africa.(PLoS Negl Trop Dis, 2015) Allan, Kathryn J; Biggs, Holly M; Halliday, Jo EB; Kazwala, Rudovick R; Maro, Venance P; Cleaveland, Sarah; Crump, John ABACKGROUND: Leptospirosis is an important but neglected bacterial zoonosis that has been largely overlooked in Africa. In this systematic review, we aimed to summarise and compare current knowledge of: (1) the geographic distribution, prevalence, incidence and diversity of acute human leptospirosis in Africa; and (2) the geographic distribution, host range, prevalence and diversity of Leptospira spp. infection in animal hosts in Africa. METHODS: Following Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines, we searched for studies that described (1) acute human leptospirosis and (2) pathogenic Leptospira spp. infection in animals. We performed a literature search using eight international and regional databases for English and non-English articles published between January 1930 to October 2014 that met out pre-defined inclusion criteria and strict case definitions. RESULTS AND DISCUSSION: We identified 97 studies that described acute human leptospirosis (n = 46) or animal Leptospira infection (n = 51) in 26 African countries. The prevalence of acute human leptospirosis ranged from 2 3% to 19 8% (n = 11) in hospital patients with febrile illness. Incidence estimates were largely restricted to the Indian Ocean islands (3 to 101 cases per 100,000 per year (n = 6)). Data from Tanzania indicate that human disease incidence is also high in mainland Africa (75 to 102 cases per 100,000 per year). Three major species (Leptospira borgpetersenii, L. interrogans and L. kirschneri) are predominant in reports from Africa and isolates from a diverse range of serogroups have been reported in human and animal infections. Cattle appear to be important hosts of a large number of Leptospira serogroups in Africa, but few data are available to allow comparison of Leptospira infection in linked human and animal populations. We advocate a 'One Health' approach to promote multidisciplinary research efforts to improve understanding of the animal to human transmission of leptospirosis on the African continent.Item Open Access Factors affecting compliance with clinical practice guidelines for pap smear screening among healthcare providers in africa: systematic review and meta-summary of 2045 individuals.(PloS one, 2013-01) Asonganyi, Etienne; Vaghasia, Meenakshi; Rodrigues, Clarissa; Phadtare, Amruta; Ford, Anne; Pietrobon, Ricardo; Atashili, Julius; Lynch, CatherineBackground
Although the importance of the Pap smear in reducing cancer incidence and mortality is known, many countries in Africa have not initiated yet widespread national cervical cancer screening programs. The World Health Organization (WHO) has published Clinical Practice Guidelines (CPGs) on cervical cancer screening in developing countries; however, there is a gap between expectations and clinical performance. Thus, the aim of this study was to conduct a systematic review and meta-summary to identify factors affecting compliance with CPGs for Pap screening among healthcare providers in Africa.Methods
And Findings: MEDLINE, Scirus, Opengate and EMBASE databases were searched in January 2012. Studies involving medical personnel practicing in Africa, whose outcome measured any factors that affect medical personnel from using a Pap smear to screen for cervical cancer, were included. Two reviewers independently evaluated titles and abstracts, then full-texts, extracted data and assessed quality of the included studies. A descriptive analysis of the included studies was conducted. We calculated Frequency effect sizes (FES) for each finding and Intensity effect sizes (IES) for each article to represent their magnitudes in the analyses. Of 1011 studies retrieved, 11 studies were included (2045 individuals). Six different themes related to the factors affecting compliance with CPGs were identified: Insufficient Knowledge/Lack of awareness (FES = 82%), Negligence/Misbeliefs (FES = 82%), Psychological Reasons (FES = 73%), Time/Cost Constraint (FES = 36%), Insufficient infrastructure/training (FES = 45%) and also no reason given (FES = 36%). IES for articles ranged between 33 and 83%.Conclusions
These results suggest that prevention initiatives should be comprehensive to include education and resources needs assessments and improvement, Pap smear test training, strategies on costing, and practitioner time studies.Item Open Access Feasibility, Acceptability, and Effectiveness of a Peer Youth Leader Model to Deliver a HIV Curriculum in Routine HIV Adolescent Clinic and Impact on Youth Leader Resilience: a Mixed-Methods Study(2019) Almarzooqi, Sahar AhmedBackground: Youth living with HIV have worse health outcomes compared to adults or children. Few interventions have been developed engaging youth in their care to promote resilience. Peer-led education is one potential way to boost confidence and bolster resilience while also improving HIV knowledge of youth living with HIV (YLHIV). Peer youth leaders (PYL) can be effective educators because they are seen as trustworthy and relatable to their peers. PYL themselves may also benefit from increased resilience and empowerment after taking on leadership position at their monthly adolescent HIV clinic. This study evaluated the acceptability, feasibility, and effectiveness of using PYL to teach an HIV education. Methods: Seven HIV-infected youth were recruited based on their previous enrollment in a mental health intervention for HIV-infected youth. Those who demonstrated confidence, excellent adherence, and upstanding behavior were chosen to become PYL. PYLs were trained by a doctor, social worker, and previously trained group leaders of a mental health intervention to teach an HIV education curriculum adapted from the Baylor International Pediatric AIDS Initiative. Trainings occurred once a week for two to three hours in preparation for teaching at the monthly adolescent HIV clinic. Two PYLs taught one-hour lessons to youth during the monthly adolescent HIV clinic. Approximately 25 clinic attendees were asked to volunteer to complete pre/post knowledge assessments and provided feedback on the PYL model. Acceptability and feasibility of using PYL to deliver an HIV curriculum to YLHIV was evaluated through attendance records, fidelity checklists and feedback notes that were documented by trained group leaders who supervised PYL curriculum delivery. In depth interviews were conducted to evaluate change in fears, motivations, and resilience among PYL before and after assuming the leadership role. PYL resilience was measured using the Connor-Davidson Scale at baseline (prior to starting the teaching role) and 6 months after initiating training. Results: A PYL model of delivering an HIV curriculum was both feasible and acceptable as reported by youth attending monthly adolescent HIV clinic and PYL. Qualitative findings showed peer education created safe discussion spaces, reduced stress of participants, and enhanced beliefs of importance in maintaining good adherence. HIV knowledge was improved as measured by self-report, and improvement did not meet statistical significant (p =0.057). PYL leaders demonstrated trends toward improved resilience as measured by Connor-Davidson Resilience Scale and increased confidence, feelings of self-worth, sense of purpose, social support, and optimism and decreased internal stigma based on in-depth interviews. Conclusions: Results demonstrated the PYL model of teaching an HIV curriculum was feasible and acceptable. PYL had improved resilience as a result of taking on a leadership role at their monthly adolescent HIV clinic. Future evaluation of YLHIV retention in care and health outcomes as a result of participation in the PYL education should be explored.
Item Open Access Food Crises, Civil Unrest, and the Political Economy(2014-09-18) Schulman, JaakovContemporary notions of food security are ever more connected to the commodification and globalization of modern agriculture. As nations continue to count on consistent and reliable commodity markets to provide food imports at competitive rates, unexpected externalities can prompt sudden spikes in worldwide food prices with severe consequences to poorer populations in developing countries. In some cases, such cost crises provoke episodes of violent unrest and place civil safety and regime stability in jeopardy. This research paper examines the specific characteristics of a political economy connected to occurrences of food-related violent civil unrest, which occurred in response to the most recent 2007-2008 food price crisis. First, this paper outlines the mechanisms of the 2007-2008 crisis and the historical context from which it emerged. Second, this paper reviews the array of existing research that connects changes in food prices with the incidence of civil unrest while presenting explanations for why such riots occurred in some countries and not others. Third, this paper presents a set of empirical measures that attempt to quantify the specific characteristics of a political economy that capture variation between the developing economies in Africa. The continent was chosen as the research sample because it experienced significant cases of civil unrest that coincided with the food price crisis. Fourth, this paper statistically tests those measures of the political economy against metrics for food-related civil unrest to reveal correlations. Finally, Egypt's experience over the course of the 2007-2008 crisis is examined as a case example. The response of Egypt’s government to the crisis is examined in order to place the quantitative models within a concrete, qualitative context. The paper proposes three empirical models with varying approaches to operationalizing the political economies of African countries around the 2007-2008 crisis. The models offer complementary explanations for variation in the incidence of food-related unrest and reliably explain the Egyptian case example as examined in this paper. Finally, the models suggest how governments may augment their capacity to take action to reduce the consequences of price crises by focusing on specific aspects of governance and economic policy.
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