Browsing by Subject "BRAF inhibitor"
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Item Open Access The macrophage: Switches from a passenger to a driver during anticancer therapy(Oncoimmunology, 2015) Wang, T; Feldman, GM; Herlyn, M; Kaufman, REWe have recently discovered that BRAF inhibitors induce potent macrophage responses that confer melanoma resistance to therapy. Our studies lay a foundation for the hypothesis that macrophages switch their role from a passenger to a driver for tumor survival during therapeutic treatment, suggesting that agents that target macrophages can be an important component of "cocktail" anticancer therapy.