Browsing by Subject "Childhood"
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Item Open Access An epigenome-wide association study of child appetitive traits and DNA methylation.(Appetite, 2023-10) Harris, Holly A; Friedman, Chloe; Starling, Anne P; Dabelea, Dana; Johnson, Susan L; Fuemmeler, Bernard F; Jima, Dereje; Murphy, Susan K; Hoyo, Cathrine; Jansen, Pauline W; Felix, Janine F; Mulder, Rosa HThe etiology of childhood appetitive traits is poorly understood. Early-life epigenetic processes may be involved in the developmental programming of appetite regulation in childhood. One such process is DNA methylation (DNAm), whereby a methyl group is added to a specific part of DNA, where a cytosine base is next to a guanine base, a CpG site. We meta-analyzed epigenome-wide association studies (EWASs) of cord blood DNAm and early-childhood appetitive traits. Data were from two independent cohorts: the Generation R Study (n = 1,086, Rotterdam, the Netherlands) and the Healthy Start study (n = 236, Colorado, USA). DNAm at autosomal methylation sites in cord blood was measured using the Illumina Infinium HumanMethylation450 BeadChip. Parents reported on their child's food responsiveness, emotional undereating, satiety responsiveness and food fussiness using the Children's Eating Behaviour Questionnaire at age 4-5 years. Multiple regression models were used to examine the association of DNAm (predictor) at the individual site- and regional-level (using DMRff) with each appetitive trait (outcome), adjusting for covariates. Bonferroni-correction was applied to adjust for multiple testing. There were no associations of DNAm and any appetitive trait when examining individual CpG-sites. However, when examining multiple CpGs jointly in so-called differentially methylated regions, we identified 45 associations of DNAm with food responsiveness, 7 associations of DNAm with emotional undereating, 13 associations of DNAm with satiety responsiveness, and 9 associations of DNAm with food fussiness. This study shows that DNAm in the newborn may partially explain variation in appetitive traits expressed in early childhood and provides preliminary support for early programming of child appetitive traits through DNAm. Investigating differential DNAm associated with appetitive traits could be an important first step in identifying biological pathways underlying the development of these behaviors.Item Open Access As the Fairy Tales Unfold(2016-05-05) Geng, YangyangThis project consists of two parts. The first part is a photo book, which includes my photographs of children and an accompanying text of individual stories of childhood, including my own. The second part is an analytical essay, which explores my process in creating and editing my photographs in the larger context of how other artists have approached the depiction of childhood. Specifically, I look at the work of photographers Wendy Ewald, Sally Mann and Olive Pierce, as each of these artists chose to depict the days of childhood by giving individual voice to the children who are most often overlooked or ignored. Over the summer of 2015, I worked with and photographed children in an orphanage school in China. I continued to make photographs of children in Durham, North Carolina and in Cuba in 2015 and 2016. As the photographs pulled me back to the past of my own childhood, I discovered that in a child’s world, ordinary things became magical vehicles and that childhood is often about the awkward process of learning to inhabit a newly bulky, changed body with aggressive needs and intensified fantasies. As a photographer, I am drawn to the beauty and pathos of the moments, when, for example, a boy, in his games, becomes a pirate, a soldier, or a sailor, or a little girl plays with a doll and imagines she is the princess. I have tried to capture and evoke the daydreams and the feelings of being lost that are specific to childhood. With my writing and in my photo book project, I have also tried to create spaces in which I allow other’s perceptions to surface with my own.Item Open Access Exploring Associations Between Prenatal PFAS Exposure and Childhood Asthma(2021-04-28) Bogar, LanePer- and polyfluoroalkyl substances (PFAS) are a large class of man-made chemicals used extensively in consumer and industrial products, making them ubiquitous in the built and natural environment. These chemicals pose a cause for concern, as there is increasing experimental and epidemiological evidence suggesting that exposure is associated with adverse health outcomes, especially prenatal PFAS exposure during critical periods of development. This study explored the associations between prenatal PFAS exposure, measured via maternal serum levels collected during pregnancy, and childhood asthma incidence in a cohort of 155 women, and 165 of their children from North Carolina. PFAS were detected in all serum samples and levels were similar to those in the general population. Statistical analyses incorporated potential predictors and covariates, including sex, age and race. After adjusting for these factors, statistically significant associations with asthma were found. Future efforts are needed to examine prenatal PFAS exposures and respiratory outcomes in later life.Item Open Access From Dennis-the-Menace to Billy-the-Kid: The Evolving Social Construction of Juvenile Offenders in the United States From 1899-2007(2010) Taylor, Ashley LaurenFew studies have historically assessed the surges and troughs of public perception regarding juvenile offenders across over a century of legislative and social change. Furthermore, a minority of juvenile crime investigations have holistically examined the interplay between changing demographic conditions (notably, economic stability, racial composition and crime rates) with its accompanying ideological shifts. Through a theoretical emphasis on social constructionism and moral panic theory, this dissertation illuminates the cyclical nature of juvenile justice reform and illustrates that panics regarding juvenile offenders are more closely related to fears regarding the maintenance of power and the insecurity that comes with historical change than with an authentic threat of juvenile crime. Over 9,000 records in The New York Times, Congressional record, and Supreme Court decisions were coded and analyzed to reveal three chronological partitions of the social construction of youthful offenders: (1) the 1890s-1930s during which the most destabilizing force to those in positions of power revolved squarely around urbanization, industrialization, and the waves of immigration from Eastern and Southern Europe; (2) the 1930s-1970s during which faith in juvenile offender rehabilitation was replaced with punitive policies stressing deterrence and an increased focus on the "problem" of racial minorities; (3) the 1970s-present which demonstrates the declining discussion of race in print media and legislative debates even as its effects in sentencing and prosecution grow in strength. This dissertation illuminates the ways in which insecurity and panic breed violence and expounds upon that notion to specify that how the violence manifests itself, whether through punitive policies or interpersonal crime, depends on the resources available and the historically-situated social norms. Over time, however, the explicit racial hostility in rhetoric and policy has been replaced with an evasion the recognition that race undoubtedly affects both juvenile justice policies as well as their implementation. In order to combat the inevitable instability that accompanies historical change, a resurgence of dialogue acknowledging the connection between race and juvenile justice is urged.
Item Open Access The Impact of a Hostel on Outcomes for Pediatric Cancer Patients in Northern Tanzania(2019) Morgan, AustinBackground: There is a significant disparity in survival rates for pediatric cancer in low and middle-income countries compared to high-income countries. A variety of factors contribute to this disparity including late stage disease at presentation, high rates of abandonment of care, and lack of supportive care. In Mwanza, Tanzania, a residential hostel was created to reduce these barriers among patients being treated for childhood cancer at Bugando Medical Centre (BMC). This study explores the potential benefit of the hostel in terms of event free survival and quality of life and examines the barriers and facilitators for completing care and the perceptions of the hostel. Methods: The study had three major components. A medical record review was conducted for 229 patients who presented to BMC in 2016-17, looking at survival outcomes. Surveys were collected from patients and caregivers who presented in 2018. In-depth interviews were conducted to explore patient/caregiver experiences. Data was collected at BMC and was analyzed with survival curves, hazard models, logistic regression, t-tests and applied thematic analysis. Results: One-year EFS was not significantly different for patients who presented to BMC before the hostel opened compared to those that presented after the hostel opened. However, a proportional hazard model showed a significantly lower hazard for patients that stayed at the hostel compared to patients that did not. Participants that stayed at the hostel also scored significantly higher in emotional functioning compared to patients that did not stay at the hostel. In-depth interview participants highlighted barriers and facilitators for completing care and described the benefits of the hostel including psychosocial support and reduced financial burden. Conclusions: Higher one-year event free survival and better scores in emotional wellbeing were observed for patients that stayed at the hostel. Caregivers and patients shared positive perceptions of the hostel as a facilitator for completing care. Key supportive care programs such as a hostel can be beneficial for improving pediatric cancer outcomes in LMICs.