Browsing by Subject "Fear conditioning"

Emotions play a fundamental role in how we remember the past. Decades of neuroscience research have uncovered the neural mechanisms that help explain why we selectively remember emotional experiences, often at the expense of more neutral ones. What remains less understood, however, are the factors that govern biased access to certain emotional memories over others. Discerning such effects can provide insight to aberrant memory biases that perpetuate psychopathological symptoms in a wide range of clinical disorders. Here I present three different routes to emotional memory bias, stemming from factors at encoding, consolidation, or retrieval that selectively influence what we remember from the past and how we remember it. First, I tested the influence of spatial proximity during initial exposure to threatening stimuli, finding that threats encountered in near space activate a distinct neural fear circuit that predicts enhanced reinstatement the next day. Second, I tested the influence of mood during consolidation, finding that mood after encoding retroactively strengthens mood-congruent content into long-term memory. Third, I tested how memories can be modified at retrieval by manipulating conceptual and perceptual features of the remembered event, finding that these two forms of reconstruction recruit distinct neural profiles. Finally, I summarize how these studies inform memory biases in mood disorders, while also discussing related work on emotion representation and dispositional biases in retrieval tendencies.

An inescapable component to survival in a dynamic environment is detecting and reacting to signals of danger. One of the most elegant processes animals possess to handle this complex task is classical conditioning, wherein stimuli associated with an aversive event acquire the capacity to elicit defensive behaviors. This process helps ensure quick reactions prior to the occurrence of an imminent threat. A problem of living in a dynamic environment, however, is that reliable signals of danger are rarely re-encountered in the exact same form from one situation to the next. Thus, to be truly adaptive it is imperative for defensive responses to extend beyond a specific instance towards other exemplars that might portend the same negative outcome. While the phenomenon of stimulus generalization was recognized in the earliest studies of conditioning from Pavlov's laboratory, a century of conditioning research has not resolved how humans and other animals actually meet this challenge. The research presented herein employs a combination of psychophysiological and functional imaging methods to examine how humans recruit neurocognitive systems to determine what stimuli do (and do not) pose a threat. Results show that human fear generalization is a complex phenomenon affected by the perceptual and conceptual nature of the stimulus. Brain regions and functional networks involved in fear generalization comprise cortical areas involved in coding the representation of conditioned stimuli and subcortical regions involved conditioned learning and the production of behavioral responses, most notably the amygdala. These results reveal the importance of stimulus-specific factors in fear learning and generalization, provide support for anatomically constrained models of fear generalization, and contribute to the development of model systems of fear generalization processes in human anxiety disorders.