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Item Open Access A high-resolution map of human evolutionary constraint using 29 mammals.(Nature, 2011-10-12) Lindblad-Toh, Kerstin; Garber, Manuel; Zuk, Or; Lin, Michael F; Parker, Brian J; Washietl, Stefan; Kheradpour, Pouya; Ernst, Jason; Jordan, Gregory; Mauceli, Evan; Ward, Lucas D; Lowe, Craig B; Holloway, Alisha K; Clamp, Michele; Gnerre, Sante; Alföldi, Jessica; Beal, Kathryn; Chang, Jean; Clawson, Hiram; Cuff, James; Di Palma, Federica; Fitzgerald, Stephen; Flicek, Paul; Guttman, Mitchell; Hubisz, Melissa J; Jaffe, David B; Jungreis, Irwin; Kent, W James; Kostka, Dennis; Lara, Marcia; Martins, Andre L; Massingham, Tim; Moltke, Ida; Raney, Brian J; Rasmussen, Matthew D; Robinson, Jim; Stark, Alexander; Vilella, Albert J; Wen, Jiayu; Xie, Xiaohui; Zody, Michael C; Broad Institute Sequencing Platform and Whole Genome Assembly Team; Baldwin, Jen; Bloom, Toby; Chin, Chee Whye; Heiman, Dave; Nicol, Robert; Nusbaum, Chad; Young, Sarah; Wilkinson, Jane; Worley, Kim C; Kovar, Christie L; Muzny, Donna M; Gibbs, Richard A; Baylor College of Medicine Human Genome Sequencing Center Sequencing Team; Cree, Andrew; Dihn, Huyen H; Fowler, Gerald; Jhangiani, Shalili; Joshi, Vandita; Lee, Sandra; Lewis, Lora R; Nazareth, Lynne V; Okwuonu, Geoffrey; Santibanez, Jireh; Warren, Wesley C; Mardis, Elaine R; Weinstock, George M; Wilson, Richard K; Genome Institute at Washington University; Delehaunty, Kim; Dooling, David; Fronik, Catrina; Fulton, Lucinda; Fulton, Bob; Graves, Tina; Minx, Patrick; Sodergren, Erica; Birney, Ewan; Margulies, Elliott H; Herrero, Javier; Green, Eric D; Haussler, David; Siepel, Adam; Goldman, Nick; Pollard, Katherine S; Pedersen, Jakob S; Lander, Eric S; Kellis, ManolisThe comparison of related genomes has emerged as a powerful lens for genome interpretation. Here we report the sequencing and comparative analysis of 29 eutherian genomes. We confirm that at least 5.5% of the human genome has undergone purifying selection, and locate constrained elements covering ∼4.2% of the genome. We use evolutionary signatures and comparisons with experimental data sets to suggest candidate functions for ∼60% of constrained bases. These elements reveal a small number of new coding exons, candidate stop codon readthrough events and over 10,000 regions of overlapping synonymous constraint within protein-coding exons. We find 220 candidate RNA structural families, and nearly a million elements overlapping potential promoter, enhancer and insulator regions. We report specific amino acid residues that have undergone positive selection, 280,000 non-coding elements exapted from mobile elements and more than 1,000 primate- and human-accelerated elements. Overlap with disease-associated variants indicates that our findings will be relevant for studies of human biology, health and disease.Item Open Access A Multiple Goal Perspective on Eating Behavior(2016) Liu, Peggy JieAlthough people frequently pursue multiple goals simultaneously, these goals often conflict with each other. For instance, consumers may have both a healthy eating goal and a goal to have an enjoyable eating experience. In this dissertation, I focus on two sources of enjoyment in eating experiences that may conflict with healthy eating: consuming tasty food (Essay 1) and affiliating with indulging dining companions (Essay 2). In both essays, I examine solutions and strategies that decrease the conflict between healthy eating and these aspects of enjoyment in the eating experience, thereby enabling consumers to resolve such goal conflicts.
Essay 1 focuses on the well-established conflict between having healthy food and having tasty food and introduces a novel product offering (“vice-virtue bundles”) that can help consumers simultaneously address both health and taste goals. Through several experiments, I demonstrate that consumers often choose vice-virtue bundles with small proportions (¼) of vice and that they view such bundles as healthier than but equally tasty as bundles with larger vice proportions, indicating that “healthier” does not always have to equal “less tasty.”
Essay 2 focuses on a conflict between healthy eating and affiliation with indulging dining companions. The first set of experiments provides evidence of this conflict and examine why it arises (Studies 1 to 3). Based on this conflict’s origins, the second set of experiments tests strategies that consumers can use to decrease the conflict between healthy eating and affiliation with an indulging dining companion (Studies 4 and 5), such that they can make healthy food choices while still being liked by an indulging dining companion. Thus, Essay 2 broadens the existing picture of goals that conflict with the healthy eating goal and, together with Essay 1, identifies solutions to such goal conflicts.
Item Open Access "A Right to be Safely Born": The Quest for Health Justice for American Mothers and Children, 1890-1965(2014) Goldman, Eden AbigailBetween 1890 and 1965, the ideology of government responsibility for maternal and child health represented a continuous and central goal that fueled programs and institutional networks of progressive and liberal social policy advocates. Beginning in the settlement houses of the 1890s, a cadre of female bureaucrats, social reformers, and their political allies developed an array of federally based programs. Conservative stakeholders--among them anti-feminists, representatives of the medical industry, anti-communists, and white supremacists--strenuously opposed this vision of health justice, arguing that health was a personal responsibility in which government should play no part. Despite the achievements of government-based progressive reformers in instituting their vision in urban settlement houses, under the Sheppard-Towner Act of the mid-1920s and during the years of the New Deal and World War II, the Cold War's approach to domestic social policy after 1947 clamped down on their vision. After this conservative turn against social democratic solutions to welfare needs, these progressive advocates shifted their attention to the international health rights movement and to community-based maternal and child health activities.
My dissertation introduces the concept of health justice as an interpretive lens to trace the history of health policy progressives and their institutional networks. On the one hand, health justice reflects the communitarian premise that the health of all members of society is essential for the common good. On the other hand, health justice implies that health and health care are individual rights that government ought to protect. While communitarian arguments were often on the tip of the tongues of social reformers, a passionate belief in citizenship-based rights and redistributive and humanitarian ideas of social justice undergirded their policy ideas and became a more explicitly stated position during the New Deal and World War II. This justice-based approach to maternal and child health policy was consistently undermined by the prevailing counter-ideologies of individual responsibility for health, local control of public services, racial segregation in health services, and the commodification of health care.
My work relies on primary evidence collected from the personal papers of key protagonists, the administrative records of the Children's Bureau housed at the National Archives, oral histories, and the presidential papers of Harry S. Truman. Published primary materials have been culled from memoirs, professional public health and medical journals, as well as the popular press. I also draw from a body of historical and political science scholarship of the past twenty-five years to contextualize the narrative.
Item Open Access Acute administration of unacylated ghrelin has no effect on Basal or stimulated insulin secretion in healthy humans.(Diabetes, 2014-07) Tong, Jenny; Davis, Harold W; Summer, Suzanne; Benoit, Stephen C; Haque, Ahrar; Bidlingmaier, Martin; Tschöp, Matthias H; D'Alessio, DavidUnacylated ghrelin (UAG) is the predominant ghrelin isoform in the circulation. Despite its inability to activate the classical ghrelin receptor, preclinical studies suggest that UAG may promote β-cell function. We hypothesized that UAG would oppose the effects of acylated ghrelin (AG) on insulin secretion and glucose tolerance. AG (1 µg/kg/h), UAG (4 µg/kg/h), combined AG+UAG, or saline were infused to 17 healthy subjects (9 men and 8 women) on four occasions in randomized order. Ghrelin was infused for 30 min to achieve steady-state levels and continued through a 3-h intravenous glucose tolerance test. The acute insulin response to glucose (AIRg), insulin sensitivity index (SI), disposition index (DI), and intravenous glucose tolerance (kg) were compared for each subject during the four infusions. AG infusion raised fasting glucose levels but had no effect on fasting plasma insulin. Compared with the saline control, AG and AG+UAG both decreased AIRg, but UAG alone had no effect. SI did not differ among the treatments. AG, but not UAG, reduced DI and kg and increased plasma growth hormone. UAG did not alter growth hormone, cortisol, glucagon, or free fatty acid levels. UAG selectively decreased glucose and fructose consumption compared with the other treatments. In contrast to previous reports, acute administration of UAG does not have independent effects on glucose tolerance or β-cell function and neither augments nor antagonizes the effects of AG.Item Open Access Aging and health--a systems biology perspective. Introduction.(Interdiscip Top Gerontol, 2015) Jazwinski, S Michal; Yashin, Anatoliy IItem Open Access An Assessment of Health Outcomes Among Orphans in the Positive Outcomes for Orphans Study in Rural Settings of Kenya and Tanzania(2011) Achwoka, Dunstan EugineObjectives: To compare measures of health and health quality between Orphans and Vulnerable Children (OVC) in different living arrangements-- institutional and community care; and to correlate different measures of OVC health and health quality using clinical, laboratory and quality of life instruments.
Design: Cross-sectional study.
Setting: Two rural districts (sites) in East Africa, Bungoma in Kenya, and Kilimanjaro in Tanzania.
Participants: 77 male and 45 female OVC aged 16-18 years (N=122). Participants, who had attained a minimum age of 16 at the date of interview, were selected from the larger sample of OVC in the Positive Outcomes for Orphans (POFO) study. POFO, a longitudinal study in five less wealthy countries that started in 2006, obtained its sample through cluster randomization.
Methods: To obtain self-ratings of OVC physical health, OVC responded to an interviewer administered SF-36 questionnaire, a multipurpose generic measure of health status. A neutral examiner then measured OVC physical health using 4 clinical variables: a physical health examination, body mass index, hemoglobin level, and the Harvard physical fitness score.
Main Outcome Measures: SF-36 scores presented as a two component score- the physical health and mental health composite sub-scores. For physical health, normal findings for age were considered as meeting the threshold for good physical health.
Results: Of the 122 OVC, 89 (73%) lived in the community while 33 (27%) lived in institutional settings. For the SF-36, the mean physical composite score for the entire study population was 50.6 (SD=6.2). Mean body mass index (BMI) was 19.3 (SD=2.4). Mean hemoglobin was found to be 13.2g/dl (SD=1.8). The average Harvard physical fitness score was found to be 40.7(SD=16.9). Pearson's correlations between SF-36 Physical Functioning and hemoglobin, BMI, and the Harvard Step-Test fitness score were 0.1, 0.1, and -0.1 respectively. There was no evidence that self-rating of OVC health outcomes differed by living arrangement. Using paired t-tests for continuous variables and chi-square tests for categorical variables, no significant p- values were obtained at the 95% level. Using a threshold of vision 20/20 for normal vision, 91.0% of community OVC and 78.8% of OVC in institutions had normal vision (p=0.07).
Conclusion: Although this study did not detect significant differences in self-reported measures of health among OVC in different living arrangements, physical examination revealed a slightly high incidence of poor vision among those living in institutions. In this sample, the correlations between SF-36 physical functioning sub-score and 3 physical health outcomes of BMI, hemoglobin, and the Harvard Step-test fitness score were weak.
Item Open Access Architectures of Aliveness: Building Beyond Gravity(2015) Boucher, Marie-PierIn the context of today's global mobility, information, bodies and goods are circulating across the globe, and even further into outer space. However, we face a paradox: the more we move, the more we become sedentary. The modes of transportation that enable our global mobility are working against us, insidiously dwindling our psycho-physical mobility. Globalization is thus not the world becoming bigger (or too big), but the world becoming immobile. Taking the body as the central non-place of political space, Architectures of Aliveness: Building Beyond Gravity interrogates the possibility of inhabiting circulation as a pragmatic form of resistance to the contemporary immobilization of life. In an era in which bodies and goods are ever more constantly in global circulation, architectures of aliveness ask, what would an experience of weightlessness do for us?
Biotechnology serves as the current dominant model for enlivening architecture and the mobility of its inhabitants. Architectures of aliveness invert the inquiry to look instead at outer space's modules of inhabitation. In questioning the possibility of making circulation inhabitable --as opposed to only inhabiting what is stationary--architectures of aliveness problematize architecture as a form of biomedia production in order to examine its capacity to impact psychic and bodily modalities toward an intensification of health. Problematized synchretically within life's mental and physical polarization, health is understood politically as an accretion of our capacity for action instead of essentially as an optimization of the biological body. The inquiry emerges at the intersection of biotechnology, neurosciences, outer space science and technology, and architecture. The analysis oscillates between historical and contemporary case studies toward an articulation that concentrates on contemporary phenomena while maintaining an historical perspective. The methodology combines archival research, interviews, and artistic and literary analysis. The analysis is informed by scientific research. More precisely, the objective is to construct an innovative mode of thinking about the fields of exchangeability between arts and sciences beyond a critique of instrumentality.
The outcomes suggest that architectures of aliveness are architectures that invite modes of inhabitation that deviate from habitualized everyday spatial engagements. It also finds that the feeling of aliveness emerges out of the production of analog or continuous space where the body is in relation with space as opposed to be represented in it. The analysis concludes that the impact of architecture on our sense of wellbeing is conditioned by proprioceptive experiences that are at once between vision and movement and yet at the same time in neither mode, suggesting an aesthetic of inhabitation based on our sense of weightedness and weightlessness.
These outcomes are thus transduced to the field of media studies to enchant biomediatic inquiry. Proposing a renewed definition of biomedia that interprets life as a form of aesthetic relation, architectures of aliveness also formulate a critique of the contemporary imperialism of visualization techniques. Architectures of aliveness conclude by questioning the political implications of its own method to suggest opacity and agonistic spaces as the biomediatic forms of political space.
Item Open Access Beta2-adrenergic receptor gene polymorphisms as systemic determinants of healthy aging in an evolutionary context.(Mech Ageing Dev, 2010-05) Kulminski, Alexander M; Culminskaya, Irina; Ukraintseva, Svetlana V; Arbeev, Konstantin G; Land, Kenneth C; Yashin, Anatoli IThe Gln(27)Glu polymorphism but not the Arg(16)Gly polymorphism of the beta2-adrenergic receptor (ADRB2) gene appears to be associated with a broad range of aging-associated phenotypes, including cancers at different sites, myocardial infarction (MI), intermittent claudication (IC), and overall/healthy longevity in the Framingham Heart Study Offspring cohort. The Gln(27)Gln genotype increases risks of cancer, MI and IC, whereas the Glu(27) allele or, equivalently, the Gly(16)Glu(27) haplotype tends to be protective against these diseases. Genetic associations with longevity are of opposite nature at young-old and oldest-old ages highlighting the phenomenon of antagonistic pleiotropy. The mechanism of antagonistic pleiotropy is associated with an evolutionary-driven advantage of carriers of a derived Gln(27) allele at younger ages and their survival disadvantage at older ages as a result of increased risks of cancer, MI and IC. The ADRB2 gene can play an important systemic role in healthy aging in evolutionary context that warrants exploration in other populations.Item Open Access Clean Cookstoves and Health in Samlout, Cambodia(2016) Li, BolunThis paper discusses results from a study of the use of cleaner cooking solutions and general health status of people in rural areas from the Battambang province of Cambodia. Data collection included 372 demographic, health and socio-economic surveys with households living in 6 villages in the Samlout district, general health examinations, and measurements of stove use and household concentrations of PM 2.5. The data reveal that health in this population is a major concern, with a very high prevalence of reported abdominal pain, nausea, chronic cough, chest pains, and fever during examinations. At the household level, we find that clean stove ownership is significantly correlated with the educational status of household head and socio-economic status of a household. Respondents from households with clean stoves appear less likely (though not statistically significantly so) to report household individuals having health problems such as occasional cough, high blood pressure and tuberculosis. Concentrations of PM2.5 are positively correlated with prevalence of occasional cough, high blood pressure and tuberculosis. Based on these results, we advise field testing and evaluation of targeted health interventions in these villages to address the numerous concerns of the local population, including exploring the potential role of clean stoves.
Item Open Access Dealing with Racism: Black Middle-Class Health in the 21st Century(2018) Tavares, CarlosThere is widespread evidence that health disparities between whites and blacks in the U.S. cannot be fully explained by inter-group socioeconomic differences. Further, research shows that racism plays a significant role in explaining racial health disparities. However, there is less research that attends to what psychosocial and socioeconomic resources may be protective of black middle-class health over time. My research starts to fill this gap by examining whether racial identity and childhood socioeconomic status are protective of black health over time.
In Chapter 2, I use data from the American Changing Lives Study (ACL) and examine whether a strong racial identity is a protective mechanism in the relationship between racism and two health outcomes: self-rated health and depressive symptoms. My findings suggest that whether racial identity is protective depends on the health outcome and the frequency of racism respondents experience. My results also indicate that middle-class is not consistently a protective factor for black health.
In Chapter 3, I use data from the National Survey of American Life (NSAL) and the ACL to investigate whether childhood socioeconomic status is associated with adult health for blacks, and particularly black women. I argue that relative childhood socioeconomic advantage is more important for disadvantaged race and race/gender groups. Further, using an intersectional approach, I argue that it is most important for black women. My findings indicate that the association of childhood socioeconomic status and adult health is significant for blacks, but not whites. I also find that childhood socioeconomic status is especially important for black women.
Item Open Access Death Traps: Holes in Urban India(Environment and Planning D: Society and Space) Solomon, HarrisItem Open Access Diferencias y disparidades de salud para la comunidad hispana en Durham(2020-04-01) Lovvorn, CarterDue to multiple factors including language and culture, predominantly Hispanic neighborhoods in Durham County may experience health differently than other areas in the county. In conjunction with the Durham County Department of Public Health, culturally and linguistically sensitive health surveys were given to Durham neighborhoods with 50% or more Hispanics to assess if and how they may experience health differently from the rest of the county. Results indicate that people from these neighborhoods are less likely to have a primary care physician and less likely to have health insurance than those from the county at large. Additionally, these communities face large amounts of discrimination and often do not get the emotional support that they need. Lastly, as a result of unsafe neighborhoods and other important factors, obesity and diabetes are a large problem within these communities. In addition to the language barrier and culture, other more structural issues like economic and environmental factors are some of the causes that can lead to adverse health outcomes in these communities. While health education resources do exist within the county, they are not commonly known and could be made more readily available.Item Open Access Employment Outcomes for Arab and Iraqi-Pakistani-Afghani Men in the United States(2012-04-27) Abdullah, HasanExecutive Summary Overview In the months following 9/11, considerable evidence suggests that anti-Islamic sentiment rose in the US and resulted in an increase in hate crimes. Anti-Islamic sentiment also likely extended to more subtle impacts such as work-place discrimination. Rigorously documenting these patterns for a representative sample of Muslims is not straightforward. Few surveys contain detailed information on religion, and those that do don’t have sufficient numbers of Muslims for most analytical purposes. Moreover, the potentially negative implications of 9/11 likely extend beyond practicing Muslims, to include those likely to be perceived as Muslims. Hypothesis I am going to examine changes over time in a set of outcomes for Arab and Iraqi-Pakistani-Afghani (IPA) men aged 25-40 with the idea that if abrupt changes shortly after 9/11 are concentrated among those groups, it is suggestive that 9/11 caused changes that differentially affected those likely to be viewed as Muslims. In other words, if individuals of ancestries suggesting they are Muslim experienced substantial discrimination after 9/11, we may be able to see evidence of it in the form of changes for these groups alone. Data This study uses observations from the American Community Survey (ACS) for years 2000-2007. I downloaded the ACS data from the University of Minnesota Population Center integrated public use micro-data series. As all answers in the ACS are recorded as outcomes in the “previous year,” the data actually reflects the years 1999-2006. Methods There are 4 treatment groups relative to 3 control groups utilized in this study. I focus on males that are aged 25-40. The four treatment groups are: (1) Immigrant Arabs (2) US-born Arabs (3) Immigrant IPA (4) US-born IPA. There are three control groups are: (1) European Whites (2) Immigrant East Asian (3) US born East Asian. This study utilizes difference-in-difference analysis through linear regressions to assess whether the time pattern in outcomes changed significantly and abruptly after 9/11 for prime-age men of Arab or IPA ancestry relative to those of European White ancestry. I also compare Arab and IPA men with those of East Asian ancestry in order to see if different patterns arise when comparing the treatment groups against another minority group of similar education and professional background. I use 6 outcome variables: • Works full time- a dichotomous variable indicating whether the respondent has a full time job. • Any work- a dichotomous variable indicating whether the respondent has worked at least one hour. • Employment- a dichotomous variable indicating whether the respondent is employed in the labor force. • Annual hours worked- the total number of hours a respondent worked. • Hourly earnings-constructed as total income divided by total annual hours work which is then logged. • Cognitive difficulty- a dichotomous variable which represents whether respondents have physical, mental, or emotional difficulties that have impaired their abilities for longer than 6 months. Results & Discussion In the US as a whole, evidence of perceived discrimination possibly due to 9/11 is slim. Possible 9/11 effects may be seen in the lack of increase in the rate of any work for immigrant Arab men and US-born IPA men shortly after 9/11. Additionally, a possible 9/11 effect may explain a short-term decrease in hourly earnings for US-born Arab men and immigrant Arab men who work full time. A more concentrated impact is seen for the treatment groups in the state analysis. A lack of increase in the rate of working full time shortly after 9/11 for immigrant IPA men in DC-Maryland-Virginia (DMV) may be a possible 9/11 effect. A similar lack of increase in employment after 9/11 for US-born Arabs in Michigan may also be the result of a 9/11 effect. Immigrant Arab men experience a decrease in earnings per hour shortly after 9/11 in both DMV and Michigan, possibly related to an immediate impact from a 9/11 effect. The treatment groups in New York experience the most changes across the outcomes that may be a result of a 9/11 effect. The rate of any work is lower for immigrant Arab men after 9/11 in New York. Additionally, for US-born Arabs who work full time in New York the only year in which they do not experience an increase in earnings is 2003. Changes in employment patterns that may be a result of a 9/11 effect is also observable in specific industries. The rate of being employed for immigrant IPA men is lower in the manufacturing and professional/scientific industry shortly after 9/11. The rate of any work for immigrant IPA men in the retail trade industry remains unchanged in 2003 while rising in every other year. US-born Arab men earn less shortly after 9/11 in the retail trade industry for all workers and full time workers. Immigrant and US-born Arab men who work full time earn less shortly after 9/11 in both the manufacturing and retail trade industry. Changes in cognitive difficulty are limited to immigrant IPA men in the manufacturing industry and US-born IPA men in the professional/scientific industry. The increased rate of cognitive difficulty for both groups may be the result of a 9/11 effect due to their immediate short-term impact. The 5.4% increase in the rate of cognitive difficulty in 2003 for immigrant IPA men in manufacturing shows a possible 9/11 effect beyond traditional employment patterns. A similar possible 9/11 effect on cognitive difficulty for US-born IPA men in professional/scientific industry is even more telling. US-born IPA men do not experience any significant difference in any outcome compared to European White men other than cognitive difficulty. But, the 36.1% increase in the rate of cognitive difficulty in 2003 and 32.2% increase in 2004 shows that even high skilled jobs may be impacted from a possible 9/11 effect.Item Open Access Epigenetics: A Paradigm Shift or Tweaking the Details?(2015-05-12) Barber, Emily*Designated as an Exemplary Master's Project for 2014-15*
We know that our lifestyle choices and experiences can influence our health: the food we eat, the environment we live in, and the social relationships we form can all have an impact on our development and health. But what if events that occur before we are even born, during our early stages of development, or even before we are conceived, determine our health in adulthood? What if our life experiences affect the health of our future, unborn descendants? Epigenetics is a field that gives us insight into the relationship between our surrounding environment and our genetic makeup, addressing the nature-nurture interaction. Epigenetics is the study of the regulation of genes, specifically how genes are activated--or turned on--and deactivated--turned off. Environmental factors such as stress, nutrition, pollution, toxins, and many others, can affect the regulation of genes without altering the genome, and this dysregulation can lead to the development of disease states. Epigenetics describes how these environmental factors can become molecularly embodied in our cells. With this new field we must ask: to what extent (if at all) does epigenetics fundamentally change our way of thinking about human (1) mental and (2) physical health? Do new insights into epigenetic processes represent a paradigm shift, and what are the conceptual and/or practical implications of epigenetics in these fields? In order to answer these questions, I will review the research that has been done on the topic, present the current paradigms in fields associated with human health and disease, identify what constitutes a paradigm shift in science, and determine if epigenetics does in fact fundamentally change how we view human health and disease. Ultimately, I determine that the aspect of epigenetics that provides the molecular mechanisms through which nature and nurture interact is merely an extension of the old paradigm. However, the idea that epigenetic changes can be transmitted through generations is novel and does constitute a paradigm shift in our thinking about human health and disease.Item Open Access Essays in Applied Microeconomics(2013) Peet, Evan DThe essays in applied microeconomics contained within this dissertation examine prices in the developing economy contexts of Indonesia and the Philippines. Prices, observed and unobserved, are determined by and incentivize the behavior of all agents in the economy. Prices describe the interaction of individuals within a household and households within a market and reveal traits critical for development. Traits such as the efficiency of household resource allocations and the completeness of markets are analyzed in Central Java, Indonesia using a rich, longitudinal survey containing detailed price data used to estimate household demand systems. Unobserved, implicit prices of environmental goods are analyzed in the context of the Philippines. The valuation of environmental quality's implicit price is illustrated by comparing the health and human capital outcomes of the highly and least exposed. Exposure to environmental toxins can produce short and long-term damages to health and human capital reflecting undervaluation of the implicit price of environmental quality. The combined results of these essays on prices in development economics reveal allocation inefficiencies within the household and the economy and provide direction for development policy around the world.
Item Open Access Essays in Health, Education and Development(2012) Cas, Ava GailThis dissertation encompasses three essays that examine the extent to which parental loss and social programs affect the health, education and time allocation of children in developing countries.
The first chapter asks the question of whether early life public health interventions have lasting or long term impact on children's human capital development. In order to answer this question, this chapter investigates the long term impact of the safe motherhood program in Indonesia on later cognition and schooling outcomes of children when they are age 11 to 17 years. The paper further investigates this question by examining the impact of the program based on exposure that began during a particular year. The findings suggest that the safe motherhood program had an impact on adolescent cognition and schooling. In particular, the program impact is relatively large and significant for those children who began exposure to the program at age 2 or younger, or not yet conceived. These estimates are robust to a series of robustness and specification checks. The results are also in general consistent with the findings in biological literature that suggest the importance of the first two years of life in shaping outcomes later in life.
The second chapter examines the question of how parental loss or absence affects child well-being. While the strategy of many papers in the literature is to use parental death due to HIV/Aids to examine this question, this chapter uses the 2004 Indian Ocean tsunami as a plausibly exogenous source of variation in parental death. In addition, the paper uses a unique longitudinal dataset that has baseline information on the same sample of individuals interviewed after the tsunami. Also, given rich data, the paper is able to look at various dimensions of child well-being which include school attendance, post-secondary aspirations, time allocation as well as educational attainment and marriage decisions for older children. The paper provides an in-depth analysis by examining the impact of parental death by age and gender of the child as well as looking at the impact in the short term and longer term. The results suggest that death of both parents, which has been little explored in the literature, has a large, negative impact on the human capital accumulation of both males and females. The loss of father alone led older males (aged 15 to 17 at the time of tsunami) to acquire less education compared to same age males whose both parents survived, while no effect is found on younger males aged 9 to 14. Furthermore, the results suggest that maternal death has little impact on schooling outcomes but does affect time allocation of children.
Finally, the third chapter examines the impact of a unique bilateral grant-aid program which provided typhoon-resistant schools and instructional equipment to the Philippines. The results suggest that the presence of both the typhoon-resistant schools and instructional equipment programs had a positive impact on the educational attainment of both men and women. The availability of instructional equipment program alone also increased the educational attainment of men but it does not seem to have had substantive effect on women. On the other hand, the availability of typhoon-resistant schools without the instructional equipment package did not have any impact on schooling outcomes of either the males or females. Except for the falsification exercise which suggests that there could be other underlying trends which may not be fully captured by the specifications, the estimates are in general robust to the inclusion of individual level characteristics, accounting of other concurrent national government's programs, restricting to municipalities in the typhoon belt region and accounting for municipality-specific trends. The findings suggest the importance of not only expanding access to schooling through increased availability of schools or classrooms (particularly, those that are resistant to natural disasters) but also the importance of improving the quality of learning through the availability of school resources that aide in students' learning in developing countries.
Item Open Access Essays on Population, Environment and Development(2018) Burrows, Michael AndrewEcological factors and the policy environment are central constraints on population well-being. This dissertation emphasizes the role of shocks to help understand the nature of such constraints, and explores the relationship between population, environment, and development in greater detail than is typically possible.
Chapter 1 opens by contributing to a growing body of evidence around the impacts of old-age pensions on the well-being of pension recipients and their families. I draw from the unique disbursement structure of a popular, widely utilized benefits program in rural Brazil, and data from two nationally representative surveys conducted in 2013 by the Brazilian Institute of Geography and Statistics. I first employ regression discontinuity design to measure the direct effect of the program’s age threshold on pension take-up. Second, I compare differences in reports of health and well-being among age-eligible and age-ineligible adults in rural areas to the same differences among populations that generally do not qualify for the benefit (i.e., urban populations). This difference-in-differences shows robust evidence of a beneficial pension effect, though along somewhat different dimensions by gender. I then show evidence of two credible mechanisms for improved health and well-being: first, improved food security within households that have eligible pension recipients; second, the cohabitation of younger family members, potentially providing support to aging family members. Taken together, this chapter demonstrates that the rural benefits program in Brazil leads to tangible health benefits for its recipients, through channels that are likely to complement rather than crowd out other public services.
Chapter 2 moves on to explore how a massive natural disaster affected smoking behavior, a common coping mechanism. External stressors are commonly hypothesized to play a role in the adoption of certain health behaviors, but understanding the role of exposure is frequently hampered by research designs and data that are inadequate for tracing causality. I use this study to evaluate the relationship between unanticipated exposure to a natural disaster and smoking behaviors using longitudinal data collected from families in Aceh, Indonesia before and after the 2004 Indian Ocean tsunami. Exposure to the tsunami is measured as a community indicator of physical proximity to damage, and as individual indicators of personal experiences at the time of the tsunami. My analysis indicates that the effect of exposure on smoking uptake varies considerably by age, and that most forms of exposure increase smoking volume. These effects appear to be temporary, but even in the context of Indonesia’s extraordinarily high smoking rates an impact is perceptible even ten years after the tsunami.
Chapter 3 delves further into the effects of the tsunami, exploring the distribution of resources after the broad destruction of infrastructure and subsequent, fast-paced reconstruction. I evaluate multiple aspects of water access for roughly 6,000 families through 2014. Logit regression analysis show increasing disparities in access to basic amounts of water, and multinomial logit regression analysis indicates that shifts are driven by a massive increase in the market for privately distributed bottled water. This study disentangles key distributional processes to show how reconstruction influenced a central social determinant of health among an already vulnerable population.
The chapters to follow aim to relate the well-being of individuals to the influences that arise from interconnected policy choices and ecological factors. The first chapter emphasizes a policy shock, the second an ecological shock, and the second seeks to identify a combined effect of the two. This original research is intended to help illuminate the role that institutions might play in improving population well-being.
Item Open Access Examination of Health Care Transition, Health Status, and Functional Outcomes Among Adolescents and Young Adults with Intellectual Disability(2020) Franklin, Michelle ScottonAdolescence is a period marked by tremendous social, emotional and physical changes; however, adolescents and young adults (AYAs) with intellectual disability (ID), who must navigate this period with limitations in intellectual and adaptive functioning, face additional difficulties. Much remains unknown about their health care transition (HCT) experiences and their health and well-being as they transition into adulthood; therefore, this study examined the HCT, health status, and functional outcomes of AYAs with ID.
This study incorporated both an individual and population approach to understand needs of AYAs with ID. First, within Chapter 1, a qualitative descriptive design study with semi-structured individual interviews with 16 parent participants was used. We utilized purposive sampling of parents with variation on race/ethnicity and AYA age, stage in transition, and condition; and we utilized content analysis. In Chapter 2, we developed a new method for identifying individuals with ID within large, population-level studies not targeted on ID. We used a secondary analysis of the de-identified, restricted-use National Longitudinal Study of Adolescent to Adult Health (Add Health) database representing 20,745 adolescents to develop a method for identifying individuals who meet criteria of ID. The Add Health ID Indicator was developed from the variables indicative of intellectual and adaptive functioning limitations available within the Add Health database. Through this method, we identified 441 AYAs with ID. Lastly, in Chapter, a descriptive, correlative study utilized the Add Health database and Add Health Indicator to examine the health status and functional outcomes among 254 AYAs with ID.
Our study illuminates the need for (a) improved infrastructure to provide effective HCT and (b) partnerships to help integrate HCT support within other life course systems. Our results support the rationale for a noncategorical HCT-focused approach as well as a parent-peer, coach-facilitated intervention for bridging the gap between systems and meeting family needs. By examining the Add Health ID sample, we identified a decline in health status from adolescence to adulthood among the AYAs with ID, demonstrating that their transition to adulthood is a period during which prevention of obesity and interventions to improve health status should be targeted. The disability-, adolescent-, and family-related factors associated with health status and functional outcomes among AYAs with ID can inform further research, tailoring of interventions, and policies. Researchers can utilize the data-driven method we developed with commonly available data elements in nationally representative datasets to leverage existing rich data sets in order to identify individuals with ID. These data sets, including Add Health, hold significant potential for answering research questions, guiding policy, and informing interventions to improve the health of the ID population.
Item Open Access Foot for Thought: Identifying Causes of Foot and Leg Pain in Rural Madagascar to Improve Musculoskeletal Health(2018-04-25) Tasnim, NoorIncidence of musculoskeletal health disorders is increasing in Madagascar. Foot pain in the Malagasy may be related to daily occupational activities or foot shape and lack of footwear. Our study tests hypotheses concerning the cause of foot pain in male and female Malagasy populations and its effects on gait kinematics. The study was conducted in Mandena, Madagascar. We obtained 89 participants’ height, mass, and age from a related study (n male = 41, n female = 48). We collected self-report data on daily activity and foot and lower limb pain. A modified Revised Foot Function Index (FFI-R) assessed pain, difficulty, and limitation of activities because of reported foot pain (total score = 27). We quantified ten standard foot shape measures. Participants walked across a force platform at self-selected speeds while being videorecorded at 120 fps. Females reported higher FFI-R scores (p = 0.029), spending more hours on their feet (p = 0.0184), and had larger BMIs (p = 0.0001) than males. Strong linear relationships were examined between participants’ self-selected speed and force curve peaks and loading rates. No significant differences were found in force curve parameters between participants with foot/ankle/knee pain and lack thereof. Males showed higher values of force curve parameters and steeper slopes when relating velocity to the same parameters. The higher foot pain and lower force peaks in females may be related to the combination of higher BMI, small feet relative to BMI, and the amount of time they are on their feet. Results suggest that a combination of BMI, foot size, and occupational factors influence foot pain in this community leading to long term injury and limitations on work. These results will help guide future interventions that promote engagement in leisure/work activities.Item Open Access Foreign Aid Allocation and Impact: A Sub-National Analysis of Malawi(2013-04-15) De, RajlakshmiThis project estimates the first sub-national model of foreign aid allocation and impact. Newly geocoded aid project data from Malawi is used in combination with multiple rounds of living standards data to predict the allocation of health aid, water aid, and education aid. In addition, the impacts of the three aid categories are detected using both instrumentation and propensity score matching methods to adjust for aid being allocated non-randomly. The three allocation models varied greatly with respect to the significant predictive covariates of diarrhea incidence, geographic region, and rural setting, but other aid allocation was a positive predictor in all three models such that areas receiving health aid were likely to also receive substantial water aid and education aid. A significant, positive effect of health aid on decreasing disease severity and a significant, positive effect of water aid on decreasing diarrhea incidence were found through both instrumentation and propensity score matching. An appropriate instrument for education aid could not be determined, but propensity score matching methods found a positive effect of education aid on school enrollment. These results suggest that foreign aid plays a useful role in poverty alleviation in Malawi and that governments should use information about local disease severity, diarrhea incidence, and school enrollment to allocate different aid types more efficiently.
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