Browsing by Subject "MDS-UPDRS"

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    ItemOpen Access
    Item Response Theory Analysis of the MDS-UPDRS Motor Examination: Tremor vs. Nontremor Items.
    (Movement disorders : official journal of the Movement Disorder Society, 2020-05-29) Tosin, Michelle Hyczy de Siqueira; Goetz, Christopher G; Luo, Sheng; Choi, Dongrak; Stebbins, Glenn T
    BACKGROUND:In PD, tremor severity behaves differently from other core motor features. However, the most commonly used assessment of overall motor severity, total MDS-UPDRS Motor Examination (Part 3) score, does not account for this distinction. OBJECTIVES:To investigate the Motor Examination (Part 3) using Item Response Theory approaches focusing on sample-independent strategies that assess how well items measure latent models of PD motor severity. METHODS:Data from 6,298 PD patients were analyzed with graded response model Item Response Theory approaches involving two analyses all 33 Part 3 items versus the 10 tremor items and 23 bradykinesia, rigidity, gait, and posture items considered separately. The strength of relationship between items and the latent measure of parkinsonian motor severity (discrimination parameter) and calculated thresholds (location parameters) were assessed using the mirt program implemented in R (R Foundation for Statistical Computing, Vienna, Austria). RESULTS:Analyzing all Part 3 items together, nontremor items demonstrated good discrimination parameters (mean = 1.83 ± 0.37) and range of thresholds (-1.73 to +4.42), but tremor items had poor discrimination (mean = 0.52 ± 0.76) and thresholds (-0.69 to 14.29). Segregating nontremor from tremor items in two independent analyses provided markedly improved discrimination and location parameters for both. CONCLUSIONS:MDS-UPDRS Part 3 tremor and nontremor items have very different relations to the construct of PD severity. Strongly improved clinimetric properties for Part 3 are obtained when tremor and nontremor items are considered separately. We suggest that evaluating PD motor severity, as an operationalized summary measure, is best attained through separate analyses with tremor and nontremor motor scores. © 2020 International Parkinson and Movement Disorder Society.
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    ItemOpen Access
    Validation of the Polish version of the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS).
    (Neurologia i neurochirurgia polska, 2020-07-08) Siuda, Joanna; Boczarska-Jedynak, Magdalena; Budrewicz, Sławomir; Dulski, Jarosław; Figura, Monika; Fiszer, Urszula; Gajos, Agata; Gorzkowska, Agnieszka; Koziorowska-Gawron, Ewa; Koziorowski, Dariusz; Krygowska-Wajs, Anna; Rudzińska-Bar, Monika; Sławek, Jarosław; Ren, Xuehan; Luo, Sheng; Martinez-Martin, Pablo; Stebbins, Glenn; Goetz, Christopher G; Opala, Grzegorz; MDS-UPDRS Polish Validation Task Force
    BACKGROUND:In 2008, the Movement Disorders Society (MDS) published a new Unified Parkinson's Disease Rating Scale (MDS-UPDRS) as the official benchmark scale for Parkinson's Disease (PD). We have translated and validated the Polish version of the MDS-UPDRS, explored its dimensionality, and compared it to the original English one. METHODS:The MDS-UPDRS was translated into Polish by a team of Polish investigators led by JS and GO. The back-translation was completed by colleagues fluent in both languages (Polish and English) who were not involved in the original translation, and was reviewed by members of the MDS Rating Scales Programme. Then the translated version of the MDS-UPDRS underwent cognitive pretesting, and the translation was modified based on the results. The final translation was approved as the Official Working Document of the MDS-UPDRS Polish version, and was tested on 355 Polish PD patients recruited at movement disorders centres all over Poland (at Katowice, Gdańsk, Łódź, Warsaw, Wrocław, and Kraków). Confirmatory and explanatory factor analyses were applied to determine whether the factor structure of the English version could be confirmed in the Polish version. RESULTS:The Polish version of the MDS-UPDRS showed satisfactory clinimetric properties. The internal consistency of the Polish version was satisfactory. In the confirmatory factor analysis, all four parts had greater than 0.90 comparative fit index (CFI) compared to the original English MDS-UPDRS. Explanatory factor analysis suggested that the Polish version differed from the English version only within an acceptable range. CONCLUSIONS AND CLINICAL IMPLICATIONS:The Polish version of the MDS-UPDRS meets the requirements to be designated as the Official Polish Version of the MDS-UPDRS, and is available on the MDS web page. We strongly recommend using the MDS-UPDRS instead of the UPDRS for research purposes and in everyday clinical practice.
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    ItemOpen Access
    Validation of the Thai Version of the Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale.
    (Journal of movement disorders, 2022-03-16) Jagota, Priya; Srivanitchapoom, Prachaya; Petchrutchatachart, Sitthi; Singmaneesakulchai, Surat; Pisarnpong, Apichart; Lolekha, Praween; Setthawatcharawanich, Suwanna; Chairangsaris, Parnsiri; Limotai, Natlada; Mekawichai, Pawut; Panyakaew, Pattamon; Phokaewvarangkul, Onanong; Sringean, Jirada; Pitakpatapee, Yuvadee; LaPelle, Nancy; Martinez-Martin, Pablo; Ren, Xuehan; Luo, Sheng; Stebbins, Glenn T; Goetz, Christopher G; Bhidayasiri, Roongroj

    Objective

    This study aims to validate the Thai translation of the Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS).

    Methods

    The English version was translated into Thai and then back-translated into English. The translated version underwent 2 rounds of cognitive pretesting to assess the ease of comprehension, ease of use and comfort with the scale. Then, it underwent large clinimetric testing.

    Results

    The Thai version was validated in 354 PD patients. The comparative fit index (CFI) for all four parts of the Thai version of the MDS-UPDRS was 0.93 or greater. Exploratory factor analysis identified isolated item differences in factor structure between the Thai and English versions.

    Conclusion

    The overall factor structure of the Thai version was consistent with that of the English version based on the high CFIs (all CFI ≥ 0.90). Hence, it can be designated the official Thai version of the MDS-UPDRS.